SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A7Z6S8

- END4_BACA2

UniProt

A7Z6S8 - END4_BACA2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable endonuclease 4

Gene
nfo, RBAM_023440
Organism
Bacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.UniRule annotation

Cofactori

Binds 3 zinc ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Zinc 1 By similarity
Metal bindingi110 – 1101Zinc 1 By similarity
Metal bindingi145 – 1451Zinc 1 By similarity
Metal bindingi145 – 1451Zinc 2 By similarity
Metal bindingi179 – 1791Zinc 2 By similarity
Metal bindingi182 – 1821Zinc 3 By similarity
Metal bindingi214 – 2141Zinc 2 By similarity
Metal bindingi227 – 2271Zinc 3 By similarity
Metal bindingi229 – 2291Zinc 3 By similarity
Metal bindingi259 – 2591Zinc 2 By similarity

GO - Molecular functioni

  1. deoxyribonuclease IV (phage-T4-induced) activity Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBAMY326423:GCM4-2342-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endonuclease 4 (EC:3.1.21.2)
Alternative name(s):
Endodeoxyribonuclease IV
Endonuclease IV
Gene namesi
Name:nfo
Ordered Locus Names:RBAM_023440
OrganismiBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001120: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Probable endonuclease 4UniRule annotationPRO_1000011288Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326423.RBAM_023440.

Structurei

3D structure databases

ProteinModelPortaliA7Z6S8.
SMRiA7Z6S8. Positions 2-297.

Family & Domainsi

Sequence similaritiesi

Belongs to the AP endonuclease 2 family.

Phylogenomic databases

eggNOGiCOG0648.
HOGENOMiHOG000224895.
KOiK01151.
OMAiIAWLKSE.
OrthoDBiEOG6Z0QCM.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00152. Nfo.
InterProiIPR001719. AP_endonuc_2.
IPR018246. AP_endonuc_F2_Zn_BS.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR21445. PTHR21445. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SMARTiSM00518. AP2Ec. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00587. nfo. 1 hit.
PROSITEiPS00729. AP_NUCLEASE_F2_1. 1 hit.
PS00730. AP_NUCLEASE_F2_2. 1 hit.
PS00731. AP_NUCLEASE_F2_3. 1 hit.
PS51432. AP_NUCLEASE_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7Z6S8-1 [UniParc]FASTAAdd to Basket

« Hide

MLKIGSHVSM SGKHMLLAAS KEAVSYGANT FMIYTGAPQN TRRKKIEDLN    50
IEAGRAHMKE NGIDEIVVHA PYIINIGNTT NPATFELGVD FLRSEIERTA 100
AIGARQIVLH PGAHVGAGAE TGIKKIIEGL NEVIVPGQNV QIALETMAGK 150
GSECGRSFEE LAEIIAGVTH NEHLSVCFDT CHTHDAGYDV ANDFDGVLNE 200
FDKIVGIDRI KVLHVNDSKN IKGARKDRHE NIGFGEIGFD ALQYIVHHEQ 250
LADIPKILET PYVGEDKKNK KPPYRFEIEM LKEKQFDKEL LEKISAQ 297
Length:297
Mass (Da):32,792
Last modified:October 23, 2007 - v1
Checksum:iC8A3FC59BE4E4DEE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000560 Genomic DNA. Translation: ABS74704.1.
RefSeqiYP_001421935.1. NC_009725.1.

Genome annotation databases

EnsemblBacteriaiABS74704; ABS74704; RBAM_023440.
GeneIDi5461457.
KEGGibay:RBAM_023440.
PATRICi18749784. VBIBacAmy31356_2367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000560 Genomic DNA. Translation: ABS74704.1 .
RefSeqi YP_001421935.1. NC_009725.1.

3D structure databases

ProteinModelPortali A7Z6S8.
SMRi A7Z6S8. Positions 2-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326423.RBAM_023440.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS74704 ; ABS74704 ; RBAM_023440 .
GeneIDi 5461457.
KEGGi bay:RBAM_023440.
PATRICi 18749784. VBIBacAmy31356_2367.

Phylogenomic databases

eggNOGi COG0648.
HOGENOMi HOG000224895.
KOi K01151.
OMAi IAWLKSE.
OrthoDBi EOG6Z0QCM.

Enzyme and pathway databases

BioCyci BAMY326423:GCM4-2342-MONOMER.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00152. Nfo.
InterProi IPR001719. AP_endonuc_2.
IPR018246. AP_endonuc_F2_Zn_BS.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view ]
PANTHERi PTHR21445. PTHR21445. 1 hit.
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
SMARTi SM00518. AP2Ec. 1 hit.
[Graphical view ]
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR00587. nfo. 1 hit.
PROSITEi PS00729. AP_NUCLEASE_F2_1. 1 hit.
PS00730. AP_NUCLEASE_F2_2. 1 hit.
PS00731. AP_NUCLEASE_F2_3. 1 hit.
PS51432. AP_NUCLEASE_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 23117 / BGSC 10A6 / FZB42.

Entry informationi

Entry nameiEND4_BACA2
AccessioniPrimary (citable) accession number: A7Z6S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi