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A7Z6S8

- END4_BACA2

UniProt

A7Z6S8 - END4_BACA2

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Protein

Probable endonuclease 4

Gene

nfo

Organism
Bacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 3 Zn(2+) ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Zinc 1UniRule annotation
Metal bindingi110 – 1101Zinc 1UniRule annotation
Metal bindingi145 – 1451Zinc 1UniRule annotation
Metal bindingi145 – 1451Zinc 2UniRule annotation
Metal bindingi179 – 1791Zinc 2UniRule annotation
Metal bindingi182 – 1821Zinc 3UniRule annotation
Metal bindingi214 – 2141Zinc 2UniRule annotation
Metal bindingi227 – 2271Zinc 3UniRule annotation
Metal bindingi229 – 2291Zinc 3UniRule annotation
Metal bindingi259 – 2591Zinc 2UniRule annotation

GO - Molecular functioni

  1. deoxyribonuclease IV (phage-T4-induced) activity Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBAMY326423:GCM4-2342-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endonuclease 4UniRule annotation (EC:3.1.21.2UniRule annotation)
Alternative name(s):
Endodeoxyribonuclease IVUniRule annotation
Endonuclease IVUniRule annotation
Gene namesi
Name:nfoUniRule annotation
Ordered Locus Names:RBAM_023440
OrganismiBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001120: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Probable endonuclease 4PRO_1000011288Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326423.RBAM_023440.

Structurei

3D structure databases

ProteinModelPortaliA7Z6S8.
SMRiA7Z6S8. Positions 2-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AP endonuclease 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0648.
HOGENOMiHOG000224895.
KOiK01151.
OMAiIAWLKSE.
OrthoDBiEOG6Z0QCM.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00152. Nfo.
InterProiIPR001719. AP_endonuc_2.
IPR018246. AP_endonuc_F2_Zn_BS.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR21445. PTHR21445. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SMARTiSM00518. AP2Ec. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00587. nfo. 1 hit.
PROSITEiPS00729. AP_NUCLEASE_F2_1. 1 hit.
PS00730. AP_NUCLEASE_F2_2. 1 hit.
PS00731. AP_NUCLEASE_F2_3. 1 hit.
PS51432. AP_NUCLEASE_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7Z6S8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKIGSHVSM SGKHMLLAAS KEAVSYGANT FMIYTGAPQN TRRKKIEDLN
60 70 80 90 100
IEAGRAHMKE NGIDEIVVHA PYIINIGNTT NPATFELGVD FLRSEIERTA
110 120 130 140 150
AIGARQIVLH PGAHVGAGAE TGIKKIIEGL NEVIVPGQNV QIALETMAGK
160 170 180 190 200
GSECGRSFEE LAEIIAGVTH NEHLSVCFDT CHTHDAGYDV ANDFDGVLNE
210 220 230 240 250
FDKIVGIDRI KVLHVNDSKN IKGARKDRHE NIGFGEIGFD ALQYIVHHEQ
260 270 280 290
LADIPKILET PYVGEDKKNK KPPYRFEIEM LKEKQFDKEL LEKISAQ
Length:297
Mass (Da):32,792
Last modified:October 23, 2007 - v1
Checksum:iC8A3FC59BE4E4DEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA. Translation: ABS74704.1.
RefSeqiYP_001421935.1. NC_009725.1.

Genome annotation databases

EnsemblBacteriaiABS74704; ABS74704; RBAM_023440.
GeneIDi5461457.
KEGGibay:RBAM_023440.
PATRICi18749784. VBIBacAmy31356_2367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA. Translation: ABS74704.1 .
RefSeqi YP_001421935.1. NC_009725.1.

3D structure databases

ProteinModelPortali A7Z6S8.
SMRi A7Z6S8. Positions 2-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326423.RBAM_023440.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS74704 ; ABS74704 ; RBAM_023440 .
GeneIDi 5461457.
KEGGi bay:RBAM_023440.
PATRICi 18749784. VBIBacAmy31356_2367.

Phylogenomic databases

eggNOGi COG0648.
HOGENOMi HOG000224895.
KOi K01151.
OMAi IAWLKSE.
OrthoDBi EOG6Z0QCM.

Enzyme and pathway databases

BioCyci BAMY326423:GCM4-2342-MONOMER.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00152. Nfo.
InterProi IPR001719. AP_endonuc_2.
IPR018246. AP_endonuc_F2_Zn_BS.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view ]
PANTHERi PTHR21445. PTHR21445. 1 hit.
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
SMARTi SM00518. AP2Ec. 1 hit.
[Graphical view ]
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR00587. nfo. 1 hit.
PROSITEi PS00729. AP_NUCLEASE_F2_1. 1 hit.
PS00730. AP_NUCLEASE_F2_2. 1 hit.
PS00731. AP_NUCLEASE_F2_3. 1 hit.
PS51432. AP_NUCLEASE_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 23117 / BGSC 10A6 / FZB42.

Entry informationi

Entry nameiEND4_BACA2
AccessioniPrimary (citable) accession number: A7Z6S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3