A7Z6M4 (GCST_BACA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	RBAM_022890

Organism

Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]

Taxonomic identifier

326423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Aminomethyltransferase HAMAP MF_00259		PRO_1000059079

Sequences

	Sequence		Length	Mass (Da)
	A7Z6M4 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 7AD509D722162545	FASTA	366	40,317
	10 20 30 40 50 60 MLKRTPLYDV YKEYGGKTID FGGWELPVQF SSIKEEHEAV RTKAGLFDVS HMGEVEVSGK 70 80 90 100 110 120 DALSFLQKMM TNDVADLKPG NALYTAMCYP DGGTVDDLLI YQKSESCYLL VINASNIEKD 130 140 150 160 170 180 IAWLTEHTEG DVTLTNQSDG ISLLAVQGPN AQSVLAKLTE CDLSSLKPFT FIDKADVAGR 190 200 210 220 230 240 QVLLSRTGYT GEDGFELYCR NEDAVHLFKE ILAAGEHEGL VPCGLGARDT LRFEAKLALY 250 260 270 280 290 300 GQELTKDITP IEAGIGFAVK HKKDSDFFGK SVLREQKEKG APRKLVGLEM IEKGIPRHGY 310 320 330 340 350 360 AVKKDGVPIG EVTTGTQSPT LKKNIGLALI KTEFSEVGTE VEVEIRKKTV KAKIVRTPFY KRPKQS

References

[1]

"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FZB42.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000560 Genomic DNA. Translation: ABS74650.1.
RefSeq	YP_001421881.1. NC_009725.1.
3D structure databases
ProteinModelPortal	A7Z6M4.
SMR	A7Z6M4. Positions 1-362.
ModBase	Search...
Protein-protein interaction databases
STRING	A7Z6M4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000005688; EBBACP00000005566; EBBACG00000005680.
GeneID	5461362.
GenomeReviews	Gene locus RBAM_022890 in contig CP000560_GR.
KEGG	bay:RBAM_022890.
PATRIC	18749670. VBIBacAmy31356_2311.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
GeneTree	EBGT00050000001932.
HOGENOM	HBG299834.
OMA	KALYGGM.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	BAMY326423:RBAM_022890-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_BACA2

Accession

Primary (citable) accession number: A7Z6M4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program