Reviewed, UniProtKB/Swiss-Prot A7Z6M3 (GCSPA_BACA2)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	RBAM_022880

Organism

Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]

Taxonomic identifier

326423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000045637

Sequences

	Sequence		Length	Mass (Da)
	A7Z6M3-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 7621707286981494	FASTA	448	49,172
	10 20 30 40 50 60 MKHRYLPATE QDKKEMLKAI GAETIDELFA DIPENVRFQK DYQIKKAKSE TELTRELTKL 70 80 90 100 110 120 AAKNKDAVTY ASFLGAGVYD HYQPVIVDHV ISRSEFYTAY TPYQPEISQG ELQAIFEFQT 130 140 150 160 170 180 MICELTGMDI ANSSMYDGGT ALAEAAMLAS GHTKKKKIVI SAAVHPESRD VLKTYAKGQY 190 200 210 220 230 240 IEVVEVPAKN GVTDLEALEH AVCDETAAVI VQYPNFFGQI EPLKDIEPLA HKGNSQLIVS 250 260 270 280 290 300 SNPLALGILT PPGAYGADIV VGDAQPFGIP AAFGGPHCGY FAVTKKLMRK VPGRLVGQTE 310 320 330 340 350 360 DENGRRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS AAMTALGKNG VKDMARQNIL 370 380 390 400 410 420 KADYARRQAE KAGLHVAFDG PIFNEFAVRL NLPVKEANRR LLQDGIIGGY DLGLAYPELN 430 440 QHMLIAVTEL RTKEKIDSLI ARLGDQHE

References

[1]

"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000560 Genomic DNA. Translation: ABS74649.1.
RefSeq	YP_001421880.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5461361.
GenomeReviews	Gene locus RBAM_022880 in contig CP000560_GR.
KEGG	bay:RBAM_022880.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A7Z6M3. VANASMY.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_BACA2

Accession

Primary (citable) accession number: A7Z6M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	June 16, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)