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A7Z6M2

- GCSPB_BACA2

UniProt

A7Z6M2 - GCSPB_BACA2

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, RBAM_022870
Organism
Bacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBAMY326423:GCM4-2285-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:RBAM_022870
OrganismiBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001120: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_1000045686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiA7Z6M2.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi326423.RBAM_022870.

Structurei

3D structure databases

ProteinModelPortaliA7Z6M2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A7Z6M2-1 [UniParc]FASTAAdd to Basket

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MNNQDQALIF EMSREGRIGY SLPELDVPET ELESLLPGDY IRDEDAKLPE    50
VSELDIMRHY TALSKRNHGV DSGFYPLGSC TMKYNPKLNE KIARIAGFSA 100
IHPLQDEDTV QGALELLYDL SGHLEEITGM DEVTLQPAAG AHGEWTGLMM 150
IRAYHEARGD FGRTKVIVPD SAHGTNPASA TVAGFETITV KSNEHGLVDI 200
EDLKRAVNEE TAALMLTNPN TLGLFEENIT EMAEIVHQAG GKLYYDGANL 250
NAVLSKARPG DMGFDVVHLN LHKTFTGPHG GGGPGSGPVG VKKEFIPYLP 300
KPVLTKKEGR LTFDYDRPQS IGRVKPYYGN FGINVRAYTY IRSMGPDGLK 350
AVTENAVLNA NYMMRRLAPY YDLPYDRHCK HEFVLSGRRQ KKLGVRTLDI 400
AKRLLDFGYH PPTVYFPLNV EESIMIEPTE TESKETLDAF IDAMIQIARE 450
AEESPEIVQE APHTTVVKRM DETKAARKPV LKYERTLDGS R 491
Length:491
Mass (Da):54,699
Last modified:October 23, 2007 - v1
Checksum:i94EB4C294AD4A3A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000560 Genomic DNA. Translation: ABS74648.1.
RefSeqiYP_001421879.1. NC_009725.1.

Genome annotation databases

EnsemblBacteriaiABS74648; ABS74648; RBAM_022870.
GeneIDi5461360.
KEGGibay:RBAM_022870.
PATRICi18749666. VBIBacAmy31356_2309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000560 Genomic DNA. Translation: ABS74648.1 .
RefSeqi YP_001421879.1. NC_009725.1.

3D structure databases

ProteinModelPortali A7Z6M2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 326423.RBAM_022870.

Proteomic databases

PRIDEi A7Z6M2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS74648 ; ABS74648 ; RBAM_022870 .
GeneIDi 5461360.
KEGGi bay:RBAM_022870.
PATRICi 18749666. VBIBacAmy31356_2309.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BAMY326423:GCM4-2285-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 23117 / BGSC 10A6 / FZB42.

Entry informationi

Entry nameiGCSPB_BACA2
AccessioniPrimary (citable) accession number: A7Z6M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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