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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:RBAM_022870
OrganismiBacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus amyloliquefaciens group
Proteomesi
  • UP000001120 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456861 – 491Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA7Z6M2
SMRiA7Z6M2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RGW Bacteria
COG1003 LUCA
HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A7Z6M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNQDQALIF EMSREGRIGY SLPELDVPET ELESLLPGDY IRDEDAKLPE
60 70 80 90 100
VSELDIMRHY TALSKRNHGV DSGFYPLGSC TMKYNPKLNE KIARIAGFSA
110 120 130 140 150
IHPLQDEDTV QGALELLYDL SGHLEEITGM DEVTLQPAAG AHGEWTGLMM
160 170 180 190 200
IRAYHEARGD FGRTKVIVPD SAHGTNPASA TVAGFETITV KSNEHGLVDI
210 220 230 240 250
EDLKRAVNEE TAALMLTNPN TLGLFEENIT EMAEIVHQAG GKLYYDGANL
260 270 280 290 300
NAVLSKARPG DMGFDVVHLN LHKTFTGPHG GGGPGSGPVG VKKEFIPYLP
310 320 330 340 350
KPVLTKKEGR LTFDYDRPQS IGRVKPYYGN FGINVRAYTY IRSMGPDGLK
360 370 380 390 400
AVTENAVLNA NYMMRRLAPY YDLPYDRHCK HEFVLSGRRQ KKLGVRTLDI
410 420 430 440 450
AKRLLDFGYH PPTVYFPLNV EESIMIEPTE TESKETLDAF IDAMIQIARE
460 470 480 490
AEESPEIVQE APHTTVVKRM DETKAARKPV LKYERTLDGS R
Length:491
Mass (Da):54,699
Last modified:October 23, 2007 - v1
Checksum:i94EB4C294AD4A3A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA Translation: ABS74648.1
RefSeqiWP_007408334.1, NC_009725.1

Genome annotation databases

EnsemblBacteriaiABS74648; ABS74648; RBAM_022870
KEGGibay:RBAM_022870

Similar proteinsi

Entry informationi

Entry nameiGCSPB_BACVZ
AccessioniPrimary (citable) accession number: A7Z6M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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