ID   NAMA_BACA2              Reviewed;         338 AA.
AC   A7Z6E7;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   16-JUN-2009, entry version 15.
DE   RecName: Full=NADPH dehydrogenase;
DE            EC=1.6.99.1;
DE   AltName: Full=Xenobiotic reductase;
GN   Name=namA; Synonyms=yqjM; OrderedLocusNames=RBAM_022120;
OS   Bacillus amyloliquefaciens (strain FZB42).
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=326423;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17704766; DOI=10.1038/nbt1325;
RA   Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K.,
RA   Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H.,
RA   Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H.,
RA   Strittmatter A., Gottschalk G., Borriss R.;
RT   "Comparative analysis of the complete genome sequence of the plant
RT   growth-promoting bacterium Bacillus amyloliquefaciens FZB42.";
RL   Nat. Biotechnol. 25:1007-1014(2007).
CC   -!- FUNCTION: Catalyzes the reduction of the double bond of an array
CC       of alpha, beta-unsaturated aldehydes and ketones. It also reduces
CC       the nitro group of nitroester and nitroaromatic compounds. It
CC       could have a role in detoxification processes (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADPH + acceptor = NADP(+) + reduced acceptor.
CC   -!- COFACTOR: FMN (By similarity).
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the NADH:flavin oxidoreductase/NADH oxidase
CC       family. NamA subfamily.
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DR   EMBL; CP000560; ABS74573.1; -; Genomic_DNA.
DR   RefSeq; YP_001421804.1; -.
DR   GeneID; 5459994; -.
DR   GenomeReviews; CP000560_GR; RBAM_022120.
DR   KEGG; bay:RBAM_022120; -.
DR   OMA; A7Z6E7; WVEDGWN.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0003959; F:NADPH dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01614; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001155; OxRdtase_FMN_N.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF00724; Oxidored_FMN; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Flavoprotein; FMN; NADP; Oxidoreductase.
FT   CHAIN         1    338       NADPH dehydrogenase.
FT                                /FTId=PRO_0000323519.
FT   BINDING      28     28       Substrate (By similarity).
FT   BINDING     164    164       Substrate (By similarity).
FT   BINDING     167    167       Substrate (By similarity).
FT   BINDING     215    215       FMN (By similarity).
FT   BINDING     308    308       FMN (By similarity).
SQ   SEQUENCE   338 AA;  37643 MW;  662EF82ED4CAAAC2 CRC64;
     MARKLFTPWT VKDVTIKNRI VMAPMCMYSS HEKDGKLQPF HMAHYISRAI GQVGLIIVEA
     TAVNPQGRIS DQDLGIWSDD HIEGFAKLTE QVKAQGSKIG IQLAHAGRKA ELEGDIYAPS
     AIPFDEQSKT PAEMTTEQIK ETIQEFKQAA ARAKEAGFDI IELHAAHGYL MHEFLSPLSN
     HRTDEYGGSH ENRYRFLGET IEAVKEVWDG PLFVRISASD YTDKGLDIAD HIGFAKWMKE
     QGVDLIDCSS GALVQADINV FPGYQVSFAE KIREQAEIAT GAVGLITTGT MAEEILQNNR
     ADLIFVAREL LRDPHFARSA AKQLNTEIPS PVQYDRAW
//