A7Z623 (AROC_BACA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	RBAM_020870

Organism

Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]

Taxonomic identifier

326423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Chorismate synthase HAMAP MF_00300		PRO_1000022459

Sequences

	Sequence		Length	Mass (Da)
	A7Z623 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 46E2B93110FA86B2	FASTA	390	42,667
	10 20 30 40 50 60 MRYLTAGESH GPQLTTIIEG VPAGLYITEE DINFELARRQ KGHGRGRRMQ IETDRAKITS 70 80 90 100 110 120 GVRHARTLGS PIALVVENKD WTHWTKIMGA APITEEEESE MKRQISRPRP GHADLNGAIK 130 140 150 160 170 180 YNHRDMRNVL ERSSARETTV RVAAGAVAKK ILAELGIKVA GHVLQIGSVK AEKTDYTSIE 190 200 210 220 230 240 DLKRVTEESP VRCYDEEAGR QMMAAIDEAK ANGDSIGGIV EVIVEGMPVG VGSYVHYDRK 250 260 270 280 290 300 LDSKLAAAVL SINAFKGVEF GIGFEAAGKN GSEVHDEIVW DEEKGYTRAT NRLGGLEGGM 310 320 330 340 350 360 TTGMPIVVRG VMKPIPTLYK PLKSVDIETK EPFTASIERS DSCAVPAASV VAEAAVAWEI 370 380 390 ANAVVEQFGL DQIDRIKENV ENMKKLSREF

References

[1]

"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FZB42.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000560 Genomic DNA. Translation: ABS74449.1.
RefSeq	YP_001421680.1. NC_009725.1.
3D structure databases
ProteinModelPortal	A7Z623.
SMR	A7Z623. Positions 1-390.
ModBase	Search...
Protein-protein interaction databases
STRING	A7Z623.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000005625; EBBACP00000005503; EBBACG00000005617.
GeneID	5462033.
GenomeReviews	Gene locus RBAM_020870 in contig CP000560_GR.
KEGG	bay:RBAM_020870.
PATRIC	18749254. VBIBacAmy31356_2103.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0082.
GeneTree	EBGT00050000002373.
HOGENOM	HBG292336.
OMA	MLRWLTA.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	BAMY326423:RBAM_020870-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BACA2

Accession

Primary (citable) accession number: A7Z623

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program