Reviewed, UniProtKB/Swiss-Prot A7Z622 (AROB_BACA2)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	RBAM_020860

Organism

Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]

Taxonomic identifier

326423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094455

Sequences

	Sequence		Length	Mass (Da)
	A7Z622-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: DB9768A33D2BBBAE	FASTA	362	40,336
	10 20 30 40 50 60 MKELEVRTAS SAYPVYIGEG IRKQAAALLS SLNRPLTKIL LIIDAEVDRL YGDEMFRLLN 70 80 90 100 110 120 ETWPVKKVIV PSGEEAKSLK EYERIQTEAI AFHMDRSSCM IAFGGGVTGD LAGFCAATFM 130 140 150 160 170 180 RGIDFIQMPT TLLAHDSAVG GKVAVNHKLG KNLIGAFYQP KAVIYDTELL KTLPEQELRS 190 200 210 220 230 240 GMAEVIKHAF IADHAFLEKL LTFDTLQGLT SAELNEMIYK GISIKSAVVR EDEKEEGIRA 250 260 270 280 290 300 FLNFGHTLGH AVEAEYGYGR ITHGDAVALG MQFALYVSEQ VARCKMNRKE LTQWLIGLGY 310 320 330 340 350 360 PGSIRQDIET PVLSARMMND KKTRGGMTQF IVLKELGEAR DCMLSKDELE NLLNKWRMEE TA

References

[1]

"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000560 Genomic DNA. Translation: ABS74448.1.
RefSeq	YP_001421679.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7Z622.
Genome annotation databases
GeneID	5462032.
GenomeReviews	Gene locus RBAM_020860 in contig CP000560_GR.
KEGG	bay:RBAM_020860.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	KANIVAQ.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BACA2

Accession

Primary (citable) accession number: A7Z622

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	October 23, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)