A7Z618 (TRPC_BACA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	RBAM_020820

Organism

Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]

Taxonomic identifier

326423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000018435

Sequences

	Sequence		Length	Mass (Da)
	A7Z618 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: D1015C5D169D96EB	FASTA	250	27,957
	10 20 30 40 50 60 MLDQIIQQKK EEIKSIVLPE TCQIERRSFK KALQNPNRFI GLIAEVKKAS PSKGLIKEHF 70 80 90 100 110 120 VPETIAADYE AAKADALSVL TDTRFFQGRN QFLTDVKQTV SLPVLRKDFI IDSLQVEESF 130 140 150 160 170 180 RIGADAILLI GEALEPSELH ELYLEAREKG MDVLVEVHDE TVLERILQVF QPDILGINNR 190 200 210 220 230 240 DLKTFRTSVS QTEKIAQLVP DGCLLVSESG IGSLADLQFV NKHGAQAVLV GESLMREDSQ 250 QKAIRGLFGE

References

[1]

"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FZB42.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000560 Genomic DNA. Translation: ABS74444.1.
RefSeq	YP_001421675.1. NC_009725.1.
3D structure databases
ProteinModelPortal	A7Z618.
ModBase	Search...
Protein-protein interaction databases
STRING	A7Z618.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000005012; EBBACP00000004890; EBBACG00000005004.
GeneID	5462028.
GenomeReviews	Gene locus RBAM_020820 in contig CP000560_GR.
KEGG	bay:RBAM_020820.
PATRIC	18749244. VBIBacAmy31356_2098.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
GeneTree	EBGT00050000001798.
HOGENOM	HBG540956.
OMA	MRKDDVT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	BAMY326423:RBAM_020820-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BACA2

Accession

Primary (citable) accession number: A7Z618

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program