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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Bacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-HAMAP
  2. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBAMY326423:GCM4-1911-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:RBAM_019130
OrganismiBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001120 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9449442-oxoglutarate dehydrogenase E1 componentPRO_1000065696Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi326423.RBAM_019130.

Structurei

3D structure databases

ProteinModelPortaliA7Z5J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiEHSNARP.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

A7Z5J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQNNMKQRM NWEDFYGPNL GYALELYDQY AEDPDSIDPD LKDMFDELGA
60 70 80 90 100
PPSQIKEASG TKEQGRVTAD LIQKIAAAVK LAEDIRTYGH LNASVNPLRK
110 120 130 140 150
DPKKSELFPL SDYGLTEEEM KAIPASVICK DAPANITNGL EAIQHLRNTY
160 170 180 190 200
KRTISFEFDH VHDFEERAWI TKMVESGELF RKNSPEKLSA VLERLTEVEG
210 220 230 240 250
FEQFLHRTFV GQKRFSIEGL DALVPVLDDI IAQSVKAGTT NVNIGMAHRG
260 270 280 290 300
RLNVLAHVLG KPYEIIFSEF QHAPNKDLVP SEGSTGISYG WTGDVKYHLG
310 320 330 340 350
ADRQLQDAET KSARITLANN PSHLEFINPI VEGSTRAAQE TRTQKGYPVQ
360 370 380 390 400
DETKSLAILI HGDAAFPGEG IVAETLNLSS LKGYQVGGAI HIIANNMIGF
410 420 430 440 450
TTESDESRST KYASDLAKGY EIPIVHVNAD DPEACLSAVK FAVEYRKRFN
460 470 480 490 500
KDFLIDLIGY RRYGHNEMDE PSTTQPMLYD AVRKHPTVKR IFAEKLVSEG
510 520 530 540 550
LISEEKAQNI ETAVTKRIED AYKKVPAKKE DAVREIELPE PVSNGFPDVD
560 570 580 590 600
TAIDFDVLRK LNGELINWPE SFNVFGKLKR ILERRAKAFD DDRKVEWSLA
610 620 630 640 650
ESLAFASILK DGTPIRLTGQ DSERGTFAQR NLVLHDSETG EEFVALHHLD
660 670 680 690 700
DCAASFTVHN SPLSEGSVLG FEYGYNVYSP ETLVMWEAQY GDFANAAQVY
710 720 730 740 750
FDQFISAGRA KWGQKSGLVM LLPHGYEGQG PEHSSGRVER FLQLAAENNW
760 770 780 790 800
TVANLTSAAQ YFHILRRQAK MLLREEIRPL VIMTPKSLLR NPNTVSEVQE
810 820 830 840 850
LSESRFKPVY EQSGLSHAYE KVTRVVLSSG KVSIDISDHF NKMEGDKDWL
860 870 880 890 900
HIARIEQLYP FPAKDTKELF AKLPNLQEIV WVQEEPQNMG AWSYISPYLS
910 920 930 940
EIAPKGVNVQ YIGRRRRSSP AEGDPTVHKK EQERIVSDSL TRKN
Length:944
Mass (Da):106,267
Last modified:October 23, 2007 - v1
Checksum:i936E7315F09C54CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA. Translation: ABS74275.1.
RefSeqiWP_012117750.1. NC_009725.1.
YP_001421506.1. NC_009725.1.

Genome annotation databases

EnsemblBacteriaiABS74275; ABS74275; RBAM_019130.
KEGGibay:RBAM_019130.
PATRICi18748902. VBIBacAmy31356_1926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA. Translation: ABS74275.1.
RefSeqiWP_012117750.1. NC_009725.1.
YP_001421506.1. NC_009725.1.

3D structure databases

ProteinModelPortaliA7Z5J9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326423.RBAM_019130.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS74275; ABS74275; RBAM_019130.
KEGGibay:RBAM_019130.
PATRICi18748902. VBIBacAmy31356_1926.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiEHSNARP.
OrthoDBiEOG6V1M1F.

Enzyme and pathway databases

BioCyciBAMY326423:GCM4-1911-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 23117 / BGSC 10A6 / FZB42.

Entry informationi

Entry nameiODO1_BACA2
AccessioniPrimary (citable) accession number: A7Z5J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: April 29, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.