A7Z522 (XYLA_BACA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xylose isomerase
EC=5.3.1.5

Gene names

Name:	xylA
Ordered Locus Names:	RBAM_017350

Organism

Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]

Taxonomic identifier

326423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455
Subunit structure	Homotetramer By similarity. HAMAP MF_00455
Subcellular location	Cytoplasm By similarity HAMAP MF_00455.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW xylose isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Xylose isomerase HAMAP MF_00455		PRO_1000026429
Sites
	Active site	107	1	By similarity
	Active site	110	1	By similarity
	Metal binding	238	1	Magnesium 1 By similarity
	Metal binding	274	1	Magnesium 1 By similarity
	Metal binding	274	1	Magnesium 2 By similarity
	Metal binding	277	1	Magnesium 2 By similarity
	Metal binding	302	1	Magnesium 1 By similarity
	Metal binding	313	1	Magnesium 2 By similarity
	Metal binding	315	1	Magnesium 2 By similarity
	Metal binding	345	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7Z522 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: FDFEDE3711D7BC93	FASTA	445	50,237
	10 20 30 40 50 60 MAHSHSGSVN YFESANKVIY EGKESTNPLA FKYYNSQEVI GGKTMKEHLR FSIAYWHTFT 70 80 90 100 110 120 ADGTDIFGAA TMQRPWDHYK GMDLARARVD AAFELFEKLD APFFAFHDRD IAPEGSTLKE 130 140 150 160 170 180 TNQNLDLIVD MIKDYMRTSG VKLLWNTANM FTNPRFVHGA ATSCNADVFA YAAAQVKKGL 190 200 210 220 230 240 ETAKELGAEN YVFWGGREGY ETLLNTDLKF ELDNMARFMH MAVDYAKEIG YTGQFLIEPK 250 260 270 280 290 300 PKEPTTHQYD TDAATTIAFL KQYGLDNHFK LNLEANHATL AGHTFEHELR MARVHGLLGS 310 320 330 340 350 360 VDANQGDPLL GWDTDEFPTD LYSATLAMYE ILKNGGLGSG GLNFDAKVRR SSFEPDDLLY 370 380 390 400 410 420 AHVAGMDTFA RGLKAARKLI EDRVFEDVIQ HRYRSFTEGI GLEIAEGRAD FKTLEQYALN 430 440 NQPIKNESGR QERLKAILNQ YILQV

References

[1]

"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FZB42.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000560 Genomic DNA. Translation: ABS74098.1.
RefSeq	YP_001421329.1. NC_009725.1.
3D structure databases
ProteinModelPortal	A7Z522.
SMR	A7Z522. Positions 11-445.
ModBase	Search...
Protein-protein interaction databases
STRING	A7Z522.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000006109; EBBACP00000005987; EBBACG00000006101.
GeneID	5462631.
GenomeReviews	Gene locus RBAM_017350 in contig CP000560_GR.
KEGG	bay:RBAM_017350.
PATRIC	18748544. VBIBacAmy31356_1748.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2115.
GeneTree	EBGT00050000002648.
HOGENOM	HBG297199.
OMA	LLGWDTD.
ProtClustDB	PRK05474.
Enzyme and pathway databases
BioCyc	BAMY326423:RBAM_017350-MONOMER.
Family and domain databases
HAMAP	MF_00455. Xylose_isom_A. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01805.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR02630. Xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA_BACA2

Accession

Primary (citable) accession number: A7Z522

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program