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A7Z4Y0

- BAEE_BACA2

UniProt

A7Z4Y0 - BAEE_BACA2

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Protein

Polyketide biosynthesis protein BaeE

Gene
baeE, RBAM_016930
Organism
Bacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probably involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. Probably has an acyl transferase activity and could also have a flavin mononucleotide-dependent oxidoreductase activity.1 Publication

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851 By similarity
Active sitei191 – 1911 By similarity

GO - Molecular functioni

  1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC
  2. nitronate monooxygenase activity Source: InterPro

GO - Biological processi

  1. antibiotic biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Enzyme and pathway databases

BioCyciBAMY326423:GCM4-1691-MONOMER.
UniPathwayiUPA01003.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyketide biosynthesis protein BaeE
Including the following 1 domains:
Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
Short name:
MCT
Gene namesi
Name:baeE
Ordered Locus Names:RBAM_016930
OrganismiBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001120: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 746746Polyketide biosynthesis protein BaeEPRO_0000388001Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326423.RBAM_016930.

Structurei

3D structure databases

ProteinModelPortaliA7Z4Y0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 312312Acyl transferaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the FabD family.

Phylogenomic databases

eggNOGiCOG0331.
HOGENOMiHOG000275975.
KOiK15329.
OMAiGGMYRGI.
OrthoDBiEOG67X1P6.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
3.40.366.10. 2 hits.
InterProiIPR004136. 2Npropane_dOase.
IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013785. Aldolase_TIM.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR014179. PfaD_fam.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF03060. NMO. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.
TIGR02814. pfaD_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

A7Z4Y0-1 [UniParc]FASTAAdd to Basket

« Hide

MISFVFPGQG SQRIGMGEDL FGRYPELTAK ADHILGYSIQ ELCRDGERLN    50
QTQFTQPALY VVNALSYLKK TEETGLKPDF TAGHSLGEYN ALYASGAFDF 100
EEGLQLVKKR GELMSRAKGG GMAAVIGLTH EQVTDVLREN HLDMIDIANM 150
NTPQQIVISG YKEDIEKAAS VFEAVNGVKM VHRLNVSGAF HSRYMLEAKE 200
EFSRFIESFH FKPLSIPVIS NVTARPYEQR ELKETLTGQI TGSVNWTDSI 250
RFLMGRKNMS FEEIGPGKVL TGLIQRITAE AEPITDEIKV PAEAGKSSIT 300
AASLGNEEFK RDYQLKYAYL AGGMYRGISS KEMVVKLAEK GMMGFFGTGG 350
LNIAHVEDAI LSIQHELRDG GSFGINVVHN MKHTDSEEKM IDLLLKHGIQ 400
NLEASAFLTV TPALVRFRAK GLKRGAGGQI IARQRIIAKL SRPEVAEAFL 450
SPAPDHILQK LAAENKITAE EASLMREIPV AHDICVEADS GGHTDGGVAY 500
SLMPAIIRLR DDMMKKYRYG KTVRIGAAGG IGTPEAAMAA FMLGADFIVT 550
GSINQCTVEA ATSGLVKDLL QQMNVQDTAY APAGDMFESG SKVQVLKKGL 600
FFPTRASKLH ELYQRHRSIE EIDEKTLRQI EEKYFKASVS SIYDKVKAHY 650
SNEDISKAER NPKEKMALIF KWYFRQSSAS AIKGDPDAKV DFQIHCGPAL 700
GAFNQWVKGT ELESWKNRHA DGIGMRLMEE TASLLNQKLG SFLQTC 746
Length:746
Mass (Da):82,426
Last modified:October 23, 2007 - v1
Checksum:iDCD623E4D0531171
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000560 Genomic DNA. Translation: ABS74056.1.
RefSeqiWP_012117591.1. NC_009725.1.
YP_001421287.1. NC_009725.1.

Genome annotation databases

EnsemblBacteriaiABS74056; ABS74056; RBAM_016930.
GeneIDi5462446.
KEGGibay:RBAM_016930.
PATRICi18748456. VBIBacAmy31356_1704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000560 Genomic DNA. Translation: ABS74056.1 .
RefSeqi WP_012117591.1. NC_009725.1.
YP_001421287.1. NC_009725.1.

3D structure databases

ProteinModelPortali A7Z4Y0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326423.RBAM_016930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS74056 ; ABS74056 ; RBAM_016930 .
GeneIDi 5462446.
KEGGi bay:RBAM_016930.
PATRICi 18748456. VBIBacAmy31356_1704.

Phylogenomic databases

eggNOGi COG0331.
HOGENOMi HOG000275975.
KOi K15329.
OMAi GGMYRGI.
OrthoDBi EOG67X1P6.

Enzyme and pathway databases

UniPathwayi UPA01003 .
BioCyci BAMY326423:GCM4-1691-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
3.40.366.10. 2 hits.
InterProi IPR004136. 2Npropane_dOase.
IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013785. Aldolase_TIM.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR014179. PfaD_fam.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
PF03060. NMO. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsi TIGR00128. fabD. 1 hit.
TIGR02814. pfaD_fam. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 23117 / BGSC 10A6 / FZB42.
  2. "Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42."
    Chen X.-H., Vater J., Piel J., Franke P., Scholz R., Schneider K., Koumoutsi A., Hitzeroth G., Grammel N., Strittmatter A.W., Gottschalk G., Suessmuth R.D., Borriss R.
    J. Bacteriol. 188:4024-4036(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PATHWAY, FUNCTION IN BACILLAENE BIOSYNTHESIS.

Entry informationi

Entry nameiBAEE_BACA2
AccessioniPrimary (citable) accession number: A7Z4Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: October 23, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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