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Protein

Polyketide biosynthesis protein BaeE

Gene

baeE

Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. Probably has an acyl transferase activity and could also have a flavin mononucleotide-dependent oxidoreductase activity.1 Publication

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi: bacillaene biosynthesis

This protein is involved in the pathway bacillaene biosynthesis, which is part of Antibiotic biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in the pathway bacillaene biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85By similarity1
Active sitei191By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAntibiotic biosynthesis

Enzyme and pathway databases

BioCyciBAMY326423:G1G84-1728-MONOMER
UniPathwayiUPA01003

Names & Taxonomyi

Protein namesi
Recommended name:
Polyketide biosynthesis protein BaeE
Including the following 1 domains:
Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
Short name:
MCT
Gene namesi
Name:baeE
Ordered Locus Names:RBAM_016930
OrganismiBacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus amyloliquefaciens group
Proteomesi
  • UP000001120 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003880011 – 746Polyketide biosynthesis protein BaeEAdd BLAST746

Proteomic databases

PRIDEiA7Z4Y0

Structurei

3D structure databases

ProteinModelPortaliA7Z4Y0
SMRiA7Z4Y0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 312Acyl transferaseAdd BLAST312

Sequence similaritiesi

In the N-terminal section; belongs to the FabD family.Curated

Phylogenomic databases

eggNOGiENOG4105CJF Bacteria
COG0331 LUCA
COG2070 LUCA
HOGENOMiHOG000275975
KOiK15329
OMAiGGMYRGI

Family and domain databases

CDDicd04742 NPD_FabD, 1 hit
Gene3Di3.20.20.70, 1 hit
3.40.366.10, 2 hits
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013785 Aldolase_TIM
IPR004410 Malonyl_CoA-ACP_transAc_FabD
IPR016036 Malonyl_transacylase_ACP-bd
IPR014179 PfaD_fam
IPR020801 PKS_acyl_transferase
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SUPFAMiSSF52151 SSF52151, 2 hits
SSF55048 SSF55048, 1 hit
TIGRFAMsiTIGR00128 fabD, 1 hit
TIGR02814 pfaD_fam, 1 hit

Sequencei

Sequence statusi: Complete.

A7Z4Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISFVFPGQG SQRIGMGEDL FGRYPELTAK ADHILGYSIQ ELCRDGERLN
60 70 80 90 100
QTQFTQPALY VVNALSYLKK TEETGLKPDF TAGHSLGEYN ALYASGAFDF
110 120 130 140 150
EEGLQLVKKR GELMSRAKGG GMAAVIGLTH EQVTDVLREN HLDMIDIANM
160 170 180 190 200
NTPQQIVISG YKEDIEKAAS VFEAVNGVKM VHRLNVSGAF HSRYMLEAKE
210 220 230 240 250
EFSRFIESFH FKPLSIPVIS NVTARPYEQR ELKETLTGQI TGSVNWTDSI
260 270 280 290 300
RFLMGRKNMS FEEIGPGKVL TGLIQRITAE AEPITDEIKV PAEAGKSSIT
310 320 330 340 350
AASLGNEEFK RDYQLKYAYL AGGMYRGISS KEMVVKLAEK GMMGFFGTGG
360 370 380 390 400
LNIAHVEDAI LSIQHELRDG GSFGINVVHN MKHTDSEEKM IDLLLKHGIQ
410 420 430 440 450
NLEASAFLTV TPALVRFRAK GLKRGAGGQI IARQRIIAKL SRPEVAEAFL
460 470 480 490 500
SPAPDHILQK LAAENKITAE EASLMREIPV AHDICVEADS GGHTDGGVAY
510 520 530 540 550
SLMPAIIRLR DDMMKKYRYG KTVRIGAAGG IGTPEAAMAA FMLGADFIVT
560 570 580 590 600
GSINQCTVEA ATSGLVKDLL QQMNVQDTAY APAGDMFESG SKVQVLKKGL
610 620 630 640 650
FFPTRASKLH ELYQRHRSIE EIDEKTLRQI EEKYFKASVS SIYDKVKAHY
660 670 680 690 700
SNEDISKAER NPKEKMALIF KWYFRQSSAS AIKGDPDAKV DFQIHCGPAL
710 720 730 740
GAFNQWVKGT ELESWKNRHA DGIGMRLMEE TASLLNQKLG SFLQTC
Length:746
Mass (Da):82,426
Last modified:October 23, 2007 - v1
Checksum:iDCD623E4D0531171
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA Translation: ABS74056.1
RefSeqiWP_012117591.1, NC_009725.1

Genome annotation databases

EnsemblBacteriaiABS74056; ABS74056; RBAM_016930
KEGGibay:RBAM_016930

Similar proteinsi

Entry informationi

Entry nameiBAEE_BACVZ
AccessioniPrimary (citable) accession number: A7Z4Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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