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A7Z4Y0 (BAEE_BACA2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polyketide biosynthesis protein BaeE

Including the following 1 domains:

  1. Malonyl CoA-acyl carrier protein transacylase
    Short name=MCT
    EC=2.3.1.39
Gene names
Name:baeE
Ordered Locus Names:RBAM_016930
OrganismBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42) [Complete proteome] [HAMAP]
Taxonomic identifier326423 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length746 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. Probably has an acyl transferase activity and could also have a flavin mononucleotide-dependent oxidoreductase activity. Ref.2

Catalytic activity

Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].

Pathway

Antibiotic biosynthesis; bacillaene biosynthesis. Ref.2

Subcellular location

Cytoplasm By similarity.

Sequence similarities

In the N-terminal section; belongs to the FabD family.

Ontologies

Keywords
   Biological processAntibiotic biosynthesis
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processantibiotic biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function[acyl-carrier-protein] S-malonyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

nitronate monooxygenase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 746746Polyketide biosynthesis protein BaeE
PRO_0000388001

Regions

Region1 – 312312Acyl transferase

Sites

Active site851 By similarity
Active site1911 By similarity

Sequences

Sequence LengthMass (Da)Tools
A7Z4Y0 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: DCD623E4D0531171

FASTA74682,426
        10         20         30         40         50         60 
MISFVFPGQG SQRIGMGEDL FGRYPELTAK ADHILGYSIQ ELCRDGERLN QTQFTQPALY 

        70         80         90        100        110        120 
VVNALSYLKK TEETGLKPDF TAGHSLGEYN ALYASGAFDF EEGLQLVKKR GELMSRAKGG 

       130        140        150        160        170        180 
GMAAVIGLTH EQVTDVLREN HLDMIDIANM NTPQQIVISG YKEDIEKAAS VFEAVNGVKM 

       190        200        210        220        230        240 
VHRLNVSGAF HSRYMLEAKE EFSRFIESFH FKPLSIPVIS NVTARPYEQR ELKETLTGQI 

       250        260        270        280        290        300 
TGSVNWTDSI RFLMGRKNMS FEEIGPGKVL TGLIQRITAE AEPITDEIKV PAEAGKSSIT 

       310        320        330        340        350        360 
AASLGNEEFK RDYQLKYAYL AGGMYRGISS KEMVVKLAEK GMMGFFGTGG LNIAHVEDAI 

       370        380        390        400        410        420 
LSIQHELRDG GSFGINVVHN MKHTDSEEKM IDLLLKHGIQ NLEASAFLTV TPALVRFRAK 

       430        440        450        460        470        480 
GLKRGAGGQI IARQRIIAKL SRPEVAEAFL SPAPDHILQK LAAENKITAE EASLMREIPV 

       490        500        510        520        530        540 
AHDICVEADS GGHTDGGVAY SLMPAIIRLR DDMMKKYRYG KTVRIGAAGG IGTPEAAMAA 

       550        560        570        580        590        600 
FMLGADFIVT GSINQCTVEA ATSGLVKDLL QQMNVQDTAY APAGDMFESG SKVQVLKKGL 

       610        620        630        640        650        660 
FFPTRASKLH ELYQRHRSIE EIDEKTLRQI EEKYFKASVS SIYDKVKAHY SNEDISKAER 

       670        680        690        700        710        720 
NPKEKMALIF KWYFRQSSAS AIKGDPDAKV DFQIHCGPAL GAFNQWVKGT ELESWKNRHA 

       730        740 
DGIGMRLMEE TASLLNQKLG SFLQTC 

« Hide

References

« Hide 'large scale' references
[1]"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42."
Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R.
Nat. Biotechnol. 25:1007-1014(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 23117 / BGSC 10A6 / FZB42.
[2]"Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42."
Chen X.-H., Vater J., Piel J., Franke P., Scholz R., Schneider K., Koumoutsi A., Hitzeroth G., Grammel N., Strittmatter A.W., Gottschalk G., Suessmuth R.D., Borriss R.
J. Bacteriol. 188:4024-4036(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PATHWAY, FUNCTION IN BACILLAENE BIOSYNTHESIS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000560 Genomic DNA. Translation: ABS74056.1.
RefSeqYP_001421287.1. NC_009725.1.

3D structure databases

ProteinModelPortalA7Z4Y0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326423.RBAM_016930.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS74056; ABS74056; RBAM_016930.
GeneID5462446.
KEGGbay:RBAM_016930.
PATRIC18748456. VBIBacAmy31356_1704.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0331.
HOGENOMHOG000275975.
KOK15329.
OMASIRFLMG.
OrthoDBEOG67X1P6.
ProtClustDBCLSK928131.

Enzyme and pathway databases

BioCycBAMY326423:GCM4-1691-MONOMER.
UniPathwayUPA01003.

Family and domain databases

Gene3D3.20.20.70. 2 hits.
3.40.366.10. 2 hits.
InterProIPR004136. 2Npropane_dOase.
IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013785. Aldolase_TIM.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR014179. PfaD_fam.
[Graphical view]
PfamPF00698. Acyl_transf_1. 1 hit.
PF03060. NMO. 1 hit.
[Graphical view]
SUPFAMSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsTIGR00128. fabD. 1 hit.
TIGR02814. pfaD_fam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBAEE_BACA2
AccessionPrimary (citable) accession number: A7Z4Y0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: October 23, 2007
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways