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A7Z4Y0

- BAEE_BACA2

UniProt

A7Z4Y0 - BAEE_BACA2

Protein

Polyketide biosynthesis protein BaeE

Gene

baeE

Organism
Bacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Probably involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. Probably has an acyl transferase activity and could also have a flavin mononucleotide-dependent oxidoreductase activity.1 Publication

    Catalytic activityi

    Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851By similarity
    Active sitei191 – 1911By similarity

    GO - Molecular functioni

    1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC
    2. nitronate monooxygenase activity Source: InterPro

    GO - Biological processi

    1. antibiotic biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Antibiotic biosynthesis

    Enzyme and pathway databases

    BioCyciBAMY326423:GCM4-1691-MONOMER.
    UniPathwayiUPA01003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyketide biosynthesis protein BaeE
    Including the following 1 domains:
    Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
    Short name:
    MCT
    Gene namesi
    Name:baeE
    Ordered Locus Names:RBAM_016930
    OrganismiBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
    Taxonomic identifieri326423 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001120: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 746746Polyketide biosynthesis protein BaeEPRO_0000388001Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326423.RBAM_016930.

    Structurei

    3D structure databases

    ProteinModelPortaliA7Z4Y0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 312312Acyl transferaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the FabD family.Curated

    Phylogenomic databases

    eggNOGiCOG0331.
    HOGENOMiHOG000275975.
    KOiK15329.
    OMAiGGMYRGI.
    OrthoDBiEOG67X1P6.

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    3.40.366.10. 2 hits.
    InterProiIPR004136. 2Npropane_dOase.
    IPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR013785. Aldolase_TIM.
    IPR004410. Malonyl_CoA-ACP_transAc_FabD.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR014179. PfaD_fam.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 1 hit.
    PF03060. NMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    TIGRFAMsiTIGR00128. fabD. 1 hit.
    TIGR02814. pfaD_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7Z4Y0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISFVFPGQG SQRIGMGEDL FGRYPELTAK ADHILGYSIQ ELCRDGERLN    50
    QTQFTQPALY VVNALSYLKK TEETGLKPDF TAGHSLGEYN ALYASGAFDF 100
    EEGLQLVKKR GELMSRAKGG GMAAVIGLTH EQVTDVLREN HLDMIDIANM 150
    NTPQQIVISG YKEDIEKAAS VFEAVNGVKM VHRLNVSGAF HSRYMLEAKE 200
    EFSRFIESFH FKPLSIPVIS NVTARPYEQR ELKETLTGQI TGSVNWTDSI 250
    RFLMGRKNMS FEEIGPGKVL TGLIQRITAE AEPITDEIKV PAEAGKSSIT 300
    AASLGNEEFK RDYQLKYAYL AGGMYRGISS KEMVVKLAEK GMMGFFGTGG 350
    LNIAHVEDAI LSIQHELRDG GSFGINVVHN MKHTDSEEKM IDLLLKHGIQ 400
    NLEASAFLTV TPALVRFRAK GLKRGAGGQI IARQRIIAKL SRPEVAEAFL 450
    SPAPDHILQK LAAENKITAE EASLMREIPV AHDICVEADS GGHTDGGVAY 500
    SLMPAIIRLR DDMMKKYRYG KTVRIGAAGG IGTPEAAMAA FMLGADFIVT 550
    GSINQCTVEA ATSGLVKDLL QQMNVQDTAY APAGDMFESG SKVQVLKKGL 600
    FFPTRASKLH ELYQRHRSIE EIDEKTLRQI EEKYFKASVS SIYDKVKAHY 650
    SNEDISKAER NPKEKMALIF KWYFRQSSAS AIKGDPDAKV DFQIHCGPAL 700
    GAFNQWVKGT ELESWKNRHA DGIGMRLMEE TASLLNQKLG SFLQTC 746
    Length:746
    Mass (Da):82,426
    Last modified:October 23, 2007 - v1
    Checksum:iDCD623E4D0531171
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000560 Genomic DNA. Translation: ABS74056.1.
    RefSeqiWP_012117591.1. NC_009725.1.
    YP_001421287.1. NC_009725.1.

    Genome annotation databases

    EnsemblBacteriaiABS74056; ABS74056; RBAM_016930.
    GeneIDi5462446.
    KEGGibay:RBAM_016930.
    PATRICi18748456. VBIBacAmy31356_1704.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000560 Genomic DNA. Translation: ABS74056.1 .
    RefSeqi WP_012117591.1. NC_009725.1.
    YP_001421287.1. NC_009725.1.

    3D structure databases

    ProteinModelPortali A7Z4Y0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326423.RBAM_016930.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS74056 ; ABS74056 ; RBAM_016930 .
    GeneIDi 5462446.
    KEGGi bay:RBAM_016930.
    PATRICi 18748456. VBIBacAmy31356_1704.

    Phylogenomic databases

    eggNOGi COG0331.
    HOGENOMi HOG000275975.
    KOi K15329.
    OMAi GGMYRGI.
    OrthoDBi EOG67X1P6.

    Enzyme and pathway databases

    UniPathwayi UPA01003 .
    BioCyci BAMY326423:GCM4-1691-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    3.40.366.10. 2 hits.
    InterProi IPR004136. 2Npropane_dOase.
    IPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR013785. Aldolase_TIM.
    IPR004410. Malonyl_CoA-ACP_transAc_FabD.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR014179. PfaD_fam.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 1 hit.
    PF03060. NMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    TIGRFAMsi TIGR00128. fabD. 1 hit.
    TIGR02814. pfaD_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 23117 / BGSC 10A6 / FZB42.
    2. "Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42."
      Chen X.-H., Vater J., Piel J., Franke P., Scholz R., Schneider K., Koumoutsi A., Hitzeroth G., Grammel N., Strittmatter A.W., Gottschalk G., Suessmuth R.D., Borriss R.
      J. Bacteriol. 188:4024-4036(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PATHWAY, FUNCTION IN BACILLAENE BIOSYNTHESIS.

    Entry informationi

    Entry nameiBAEE_BACA2
    AccessioniPrimary (citable) accession number: A7Z4Y0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3