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Protein

Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC

Gene

baeC

Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the transfer of the malonyl-CoA group to the acyl-carrier-protein AcpK (Mal-AcpK) (By similarity).By similarity1 Publication

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi: bacillaene biosynthesis

This protein is involved in the pathway bacillaene biosynthesis, which is part of Antibiotic biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in the pathway bacillaene biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87By similarity1
Active sitei193By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAntibiotic biosynthesis

Enzyme and pathway databases

BioCyciBAMY326423:G1G84-1726-MONOMER
UniPathwayiUPA01003

Names & Taxonomyi

Protein namesi
Recommended name:
Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC (EC:2.3.1.39)
Short name:
AT
Gene namesi
Name:baeC
Ordered Locus Names:RBAM_016910
OrganismiBacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus amyloliquefaciens group
Proteomesi
  • UP000001120 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003880031 – 289Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeCAdd BLAST289

Structurei

3D structure databases

ProteinModelPortaliA7Z4X8
SMRiA7Z4X8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.Curated

Phylogenomic databases

eggNOGiENOG4105CJF Bacteria
COG0331 LUCA
HOGENOMiHOG000036504
KOiK15327
OMAiQKQGMGS

Family and domain databases

Gene3Di3.40.366.10, 2 hits
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR024925 Malonyl_CoA-ACP_transAc
IPR004410 Malonyl_CoA-ACP_transAc_FabD
IPR016036 Malonyl_transacylase_ACP-bd
IPR020801 PKS_acyl_transferase
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PIRSFiPIRSF000446 Mct, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SUPFAMiSSF52151 SSF52151, 2 hits
SSF55048 SSF55048, 1 hit
TIGRFAMsiTIGR00128 fabD, 1 hit

Sequencei

Sequence statusi: Complete.

A7Z4X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITYLFPGQG SQKQGMGSSL FDEFKDLTEQ ADETLGYSMK RLCLENPYSN
60 70 80 90 100
LHKTQFTQPA LYVVNVLSYL KKIQDNDIKP DYVAGHSLGE YNALFAAGAF
110 120 130 140 150
DFITGLQLVR KRGELMSMAT DGKMAAVMGL TAAQVSDALQ THGLHTIDIA
160 170 180 190 200
NMNSPHQVVI SGRKEDIERA KSVFEGLKDV TMFHPLNVSG AFHSRYMSEA
210 220 230 240 250
KQEFEKFLQS FHFSAISIPV ISNVHARPYE QDGIHSVLAD QIDHSVRWND
260 270 280
SIRYLLDKGR MEFEEVGPGH VLTGLIHRIK NETEASPAM
Length:289
Mass (Da):32,318
Last modified:October 23, 2007 - v1
Checksum:iC85AA1EED2BDCE95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA Translation: ABS74054.1
RefSeqiWP_012117589.1, NC_009725.1

Genome annotation databases

EnsemblBacteriaiABS74054; ABS74054; RBAM_016910
KEGGibay:RBAM_016910

Similar proteinsi

Entry informationi

Entry nameiBAEC_BACVZ
AccessioniPrimary (citable) accession number: A7Z4X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: October 23, 2007
Last modified: April 25, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health