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A7Z4X8 (BAEC_BACA2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC

Short name=AT
EC=2.3.1.39
Gene names
Name:baeC
Ordered Locus Names:RBAM_016910
OrganismBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42) [Complete proteome] [HAMAP]
Taxonomic identifier326423 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the transfer of the malonyl-CoA group to the acyl-carrier-protein AcpK (Mal-AcpK) By similarity. Ref.2

Catalytic activity

Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].

Pathway

Antibiotic biosynthesis; bacillaene biosynthesis. Ref.2

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the FabD family.

Ontologies

Keywords
   Biological processAntibiotic biosynthesis
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processantibiotic biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function[acyl-carrier-protein] S-malonyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC
PRO_0000388003

Sites

Active site871 By similarity
Active site1931 By similarity

Sequences

Sequence LengthMass (Da)Tools
A7Z4X8 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: C85AA1EED2BDCE95

FASTA28932,318
        10         20         30         40         50         60 
MITYLFPGQG SQKQGMGSSL FDEFKDLTEQ ADETLGYSMK RLCLENPYSN LHKTQFTQPA 

        70         80         90        100        110        120 
LYVVNVLSYL KKIQDNDIKP DYVAGHSLGE YNALFAAGAF DFITGLQLVR KRGELMSMAT 

       130        140        150        160        170        180 
DGKMAAVMGL TAAQVSDALQ THGLHTIDIA NMNSPHQVVI SGRKEDIERA KSVFEGLKDV 

       190        200        210        220        230        240 
TMFHPLNVSG AFHSRYMSEA KQEFEKFLQS FHFSAISIPV ISNVHARPYE QDGIHSVLAD 

       250        260        270        280 
QIDHSVRWND SIRYLLDKGR MEFEEVGPGH VLTGLIHRIK NETEASPAM 

« Hide

References

« Hide 'large scale' references
[1]"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42."
Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R.
Nat. Biotechnol. 25:1007-1014(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 23117 / BGSC 10A6 / FZB42.
[2]"Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42."
Chen X.-H., Vater J., Piel J., Franke P., Scholz R., Schneider K., Koumoutsi A., Hitzeroth G., Grammel N., Strittmatter A.W., Gottschalk G., Suessmuth R.D., Borriss R.
J. Bacteriol. 188:4024-4036(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PATHWAY, FUNCTION IN BACILLAENE BIOSYNTHESIS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000560 Genomic DNA. Translation: ABS74054.1.
RefSeqYP_001421285.1. NC_009725.1.

3D structure databases

ProteinModelPortalA7Z4X8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326423.RBAM_016910.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS74054; ABS74054; RBAM_016910.
GeneID5460079.
KEGGbay:RBAM_016910.
PATRIC18748452. VBIBacAmy31356_1702.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0331.
HOGENOMHOG000036504.
KOK15327.
OMACLENPYS.
OrthoDBEOG6W19KW.
ProtClustDBCLSK887323.

Enzyme and pathway databases

BioCycBAMY326423:GCM4-1689-MONOMER.
UniPathwayUPA01003.

Family and domain databases

Gene3D3.40.366.10. 2 hits.
InterProIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFPIRSF000446. Mct. 1 hit.
SUPFAMSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsTIGR00128. fabD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBAEC_BACA2
AccessionPrimary (citable) accession number: A7Z4X8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: October 23, 2007
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways