A7Z4X8 (BAEC_BACA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC
Short name=AT
EC=2.3.1.39

Gene names

Name:	baeC
Ordered Locus Names:	RBAM_016910

Organism

Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]

Taxonomic identifier

326423 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus subtilis group › Bacillus amyloliquefaciens › Bacillus amyloliquefaciens subsp. plantarum

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the transfer of the malonyl-CoA group to the acyl-carrier-protein AcpK (Mal-AcpK) By similarity. Ref.2
Catalytic activity	Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].
Pathway	Antibiotic biosynthesis; bacillaene biosynthesis. Ref.2
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FabD family.

Ontologies

Keywords
Biological process	Antibiotic biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	antibiotic biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	[acyl-carrier-protein] S-malonyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC		PRO_0000388003
Sites
	Active site	87	1	By similarity
	Active site	193	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7Z4X8 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: C85AA1EED2BDCE95	FASTA	289	32,318
	10 20 30 40 50 60 MITYLFPGQG SQKQGMGSSL FDEFKDLTEQ ADETLGYSMK RLCLENPYSN LHKTQFTQPA 70 80 90 100 110 120 LYVVNVLSYL KKIQDNDIKP DYVAGHSLGE YNALFAAGAF DFITGLQLVR KRGELMSMAT 130 140 150 160 170 180 DGKMAAVMGL TAAQVSDALQ THGLHTIDIA NMNSPHQVVI SGRKEDIERA KSVFEGLKDV 190 200 210 220 230 240 TMFHPLNVSG AFHSRYMSEA KQEFEKFLQS FHFSAISIPV ISNVHARPYE QDGIHSVLAD 250 260 270 280 QIDHSVRWND SIRYLLDKGR MEFEEVGPGH VLTGLIHRIK NETEASPAM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FZB42.
[2]	"Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42." Chen X.-H., Vater J., Piel J., Franke P., Scholz R., Schneider K., Koumoutsi A., Hitzeroth G., Grammel N., Strittmatter A.W., Gottschalk G., Suessmuth R.D., Borriss R. J. Bacteriol. 188:4024-4036(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PATHWAY, FUNCTION IN BACILLAENE BIOSYNTHESIS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000560 Genomic DNA. Translation: ABS74054.1.
RefSeq	YP_001421285.1. NC_009725.1.
3D structure databases
ProteinModelPortal	A7Z4X8.
ModBase	Search...
Protein-protein interaction databases
STRING	326423.RBAM_016910.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABS74054; ABS74054; RBAM_016910.
GeneID	5460079.
KEGG	bay:RBAM_016910.
PATRIC	18748452. VBIBacAmy31356_1702.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0331.
HOGENOM	HOG000036504.
KO	K15327.
OMA	CLENPYS.
ProtClustDB	CLSK887323.
Enzyme and pathway databases
UniPathway	UPA01003.
Family and domain databases
Gene3D	3.40.366.10. 2 hits.
InterPro	IPR001227. Ac_transferase_dom. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR024925. Malonyl_CoA-ACP_transAc. IPR004410. Malonyl_CoA-ACP_transAc_FabD. IPR016036. Malonyl_transacylase_ACP-bd. [Graphical view]
Pfam	PF00698. Acyl_transf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000446. Mct. 1 hit.
SUPFAM	SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF55048. Malonyl_transacylase_ACP-bd. 1 hit.
TIGRFAMs	TIGR00128. fabD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BAEC_BACA2

Accession

Primary (citable) accession number: A7Z4X8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program