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Protein

Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC

Gene

baeC

Organism
Bacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the transfer of the malonyl-CoA group to the acyl-carrier-protein AcpK (Mal-AcpK) (By similarity).By similarity

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871By similarity
Active sitei193 – 1931By similarity

GO - Molecular functioni

  1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. antibiotic biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Enzyme and pathway databases

BioCyciBAMY326423:GCM4-1689-MONOMER.
UniPathwayiUPA01003.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC (EC:2.3.1.39)
Short name:
AT
Gene namesi
Name:baeC
Ordered Locus Names:RBAM_016910
OrganismiBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001120 Componenti: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeCPRO_0000388003Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326423.RBAM_016910.

Structurei

3D structure databases

ProteinModelPortaliA7Z4X8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.Curated

Phylogenomic databases

eggNOGiCOG0331.
HOGENOMiHOG000036504.
KOiK15327.
OMAiCLENPYS.
OrthoDBiEOG6W19KW.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.

Sequencei

Sequence statusi: Complete.

A7Z4X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITYLFPGQG SQKQGMGSSL FDEFKDLTEQ ADETLGYSMK RLCLENPYSN
60 70 80 90 100
LHKTQFTQPA LYVVNVLSYL KKIQDNDIKP DYVAGHSLGE YNALFAAGAF
110 120 130 140 150
DFITGLQLVR KRGELMSMAT DGKMAAVMGL TAAQVSDALQ THGLHTIDIA
160 170 180 190 200
NMNSPHQVVI SGRKEDIERA KSVFEGLKDV TMFHPLNVSG AFHSRYMSEA
210 220 230 240 250
KQEFEKFLQS FHFSAISIPV ISNVHARPYE QDGIHSVLAD QIDHSVRWND
260 270 280
SIRYLLDKGR MEFEEVGPGH VLTGLIHRIK NETEASPAM
Length:289
Mass (Da):32,318
Last modified:October 22, 2007 - v1
Checksum:iC85AA1EED2BDCE95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA. Translation: ABS74054.1.
RefSeqiYP_001421285.1. NC_009725.1.

Genome annotation databases

EnsemblBacteriaiABS74054; ABS74054; RBAM_016910.
KEGGibay:RBAM_016910.
PATRICi18748452. VBIBacAmy31356_1702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA. Translation: ABS74054.1.
RefSeqiYP_001421285.1. NC_009725.1.

3D structure databases

ProteinModelPortaliA7Z4X8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326423.RBAM_016910.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS74054; ABS74054; RBAM_016910.
KEGGibay:RBAM_016910.
PATRICi18748452. VBIBacAmy31356_1702.

Phylogenomic databases

eggNOGiCOG0331.
HOGENOMiHOG000036504.
KOiK15327.
OMAiCLENPYS.
OrthoDBiEOG6W19KW.

Enzyme and pathway databases

UniPathwayiUPA01003.
BioCyciBAMY326423:GCM4-1689-MONOMER.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 23117 / BGSC 10A6 / FZB42.
  2. "Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42."
    Chen X.-H., Vater J., Piel J., Franke P., Scholz R., Schneider K., Koumoutsi A., Hitzeroth G., Grammel N., Strittmatter A.W., Gottschalk G., Suessmuth R.D., Borriss R.
    J. Bacteriol. 188:4024-4036(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PATHWAY, FUNCTION IN BACILLAENE BIOSYNTHESIS.

Entry informationi

Entry nameiBAEC_BACA2
AccessioniPrimary (citable) accession number: A7Z4X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2009
Last sequence update: October 22, 2007
Last modified: March 31, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.