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A7Z4X8

- BAEC_BACA2

UniProt

A7Z4X8 - BAEC_BACA2

Protein

Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC

Gene

baeC

Organism
Bacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the transfer of the malonyl-CoA group to the acyl-carrier-protein AcpK (Mal-AcpK) By similarity.By similarity

    Catalytic activityi

    Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei87 – 871By similarity
    Active sitei193 – 1931By similarity

    GO - Molecular functioni

    1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. antibiotic biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Antibiotic biosynthesis

    Enzyme and pathway databases

    BioCyciBAMY326423:GCM4-1689-MONOMER.
    UniPathwayiUPA01003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC (EC:2.3.1.39)
    Short name:
    AT
    Gene namesi
    Name:baeC
    Ordered Locus Names:RBAM_016910
    OrganismiBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
    Taxonomic identifieri326423 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001120: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeCPRO_0000388003Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326423.RBAM_016910.

    Structurei

    3D structure databases

    ProteinModelPortaliA7Z4X8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FabD family.Curated

    Phylogenomic databases

    eggNOGiCOG0331.
    HOGENOMiHOG000036504.
    KOiK15327.
    OMAiCLENPYS.
    OrthoDBiEOG6W19KW.

    Family and domain databases

    Gene3Di3.40.366.10. 2 hits.
    InterProiIPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR024925. Malonyl_CoA-ACP_transAc.
    IPR004410. Malonyl_CoA-ACP_transAc_FabD.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000446. Mct. 1 hit.
    SUPFAMiSSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    TIGRFAMsiTIGR00128. fabD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7Z4X8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITYLFPGQG SQKQGMGSSL FDEFKDLTEQ ADETLGYSMK RLCLENPYSN    50
    LHKTQFTQPA LYVVNVLSYL KKIQDNDIKP DYVAGHSLGE YNALFAAGAF 100
    DFITGLQLVR KRGELMSMAT DGKMAAVMGL TAAQVSDALQ THGLHTIDIA 150
    NMNSPHQVVI SGRKEDIERA KSVFEGLKDV TMFHPLNVSG AFHSRYMSEA 200
    KQEFEKFLQS FHFSAISIPV ISNVHARPYE QDGIHSVLAD QIDHSVRWND 250
    SIRYLLDKGR MEFEEVGPGH VLTGLIHRIK NETEASPAM 289
    Length:289
    Mass (Da):32,318
    Last modified:October 23, 2007 - v1
    Checksum:iC85AA1EED2BDCE95
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000560 Genomic DNA. Translation: ABS74054.1.
    RefSeqiYP_001421285.1. NC_009725.1.

    Genome annotation databases

    EnsemblBacteriaiABS74054; ABS74054; RBAM_016910.
    GeneIDi5460079.
    KEGGibay:RBAM_016910.
    PATRICi18748452. VBIBacAmy31356_1702.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000560 Genomic DNA. Translation: ABS74054.1 .
    RefSeqi YP_001421285.1. NC_009725.1.

    3D structure databases

    ProteinModelPortali A7Z4X8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326423.RBAM_016910.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS74054 ; ABS74054 ; RBAM_016910 .
    GeneIDi 5460079.
    KEGGi bay:RBAM_016910.
    PATRICi 18748452. VBIBacAmy31356_1702.

    Phylogenomic databases

    eggNOGi COG0331.
    HOGENOMi HOG000036504.
    KOi K15327.
    OMAi CLENPYS.
    OrthoDBi EOG6W19KW.

    Enzyme and pathway databases

    UniPathwayi UPA01003 .
    BioCyci BAMY326423:GCM4-1689-MONOMER.

    Family and domain databases

    Gene3Di 3.40.366.10. 2 hits.
    InterProi IPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR024925. Malonyl_CoA-ACP_transAc.
    IPR004410. Malonyl_CoA-ACP_transAc_FabD.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000446. Mct. 1 hit.
    SUPFAMi SSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    TIGRFAMsi TIGR00128. fabD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 23117 / BGSC 10A6 / FZB42.
    2. "Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42."
      Chen X.-H., Vater J., Piel J., Franke P., Scholz R., Schneider K., Koumoutsi A., Hitzeroth G., Grammel N., Strittmatter A.W., Gottschalk G., Suessmuth R.D., Borriss R.
      J. Bacteriol. 188:4024-4036(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PATHWAY, FUNCTION IN BACILLAENE BIOSYNTHESIS.

    Entry informationi

    Entry nameiBAEC_BACA2
    AccessioniPrimary (citable) accession number: A7Z4X8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3