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A7Z4X8

- BAEC_BACA2

UniProt

A7Z4X8 - BAEC_BACA2

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Protein
Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC
Gene
baeC, RBAM_016910
Organism
Bacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the transfer of the malonyl-CoA group to the acyl-carrier-protein AcpK (Mal-AcpK) By similarity.1 Publication

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871 By similarity
Active sitei193 – 1931 By similarity

GO - Molecular functioni

  1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. antibiotic biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic biosynthesis

Enzyme and pathway databases

BioCyciBAMY326423:GCM4-1689-MONOMER.
UniPathwayiUPA01003.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC (EC:2.3.1.39)
Short name:
AT
Gene namesi
Name:baeC
Ordered Locus Names:RBAM_016910
OrganismiBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001120: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase BaeC
PRO_0000388003Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326423.RBAM_016910.

Structurei

3D structure databases

ProteinModelPortaliA7Z4X8.

Family & Domainsi

Sequence similaritiesi

Belongs to the FabD family.

Phylogenomic databases

eggNOGiCOG0331.
HOGENOMiHOG000036504.
KOiK15327.
OMAiCLENPYS.
OrthoDBiEOG6W19KW.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000446. Mct. 1 hit.
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsiTIGR00128. fabD. 1 hit.

Sequencei

Sequence statusi: Complete.

A7Z4X8-1 [UniParc]FASTAAdd to Basket

« Hide

MITYLFPGQG SQKQGMGSSL FDEFKDLTEQ ADETLGYSMK RLCLENPYSN    50
LHKTQFTQPA LYVVNVLSYL KKIQDNDIKP DYVAGHSLGE YNALFAAGAF 100
DFITGLQLVR KRGELMSMAT DGKMAAVMGL TAAQVSDALQ THGLHTIDIA 150
NMNSPHQVVI SGRKEDIERA KSVFEGLKDV TMFHPLNVSG AFHSRYMSEA 200
KQEFEKFLQS FHFSAISIPV ISNVHARPYE QDGIHSVLAD QIDHSVRWND 250
SIRYLLDKGR MEFEEVGPGH VLTGLIHRIK NETEASPAM 289
Length:289
Mass (Da):32,318
Last modified:October 23, 2007 - v1
Checksum:iC85AA1EED2BDCE95
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000560 Genomic DNA. Translation: ABS74054.1.
RefSeqiYP_001421285.1. NC_009725.1.

Genome annotation databases

EnsemblBacteriaiABS74054; ABS74054; RBAM_016910.
GeneIDi5460079.
KEGGibay:RBAM_016910.
PATRICi18748452. VBIBacAmy31356_1702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000560 Genomic DNA. Translation: ABS74054.1 .
RefSeqi YP_001421285.1. NC_009725.1.

3D structure databases

ProteinModelPortali A7Z4X8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326423.RBAM_016910.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS74054 ; ABS74054 ; RBAM_016910 .
GeneIDi 5460079.
KEGGi bay:RBAM_016910.
PATRICi 18748452. VBIBacAmy31356_1702.

Phylogenomic databases

eggNOGi COG0331.
HOGENOMi HOG000036504.
KOi K15327.
OMAi CLENPYS.
OrthoDBi EOG6W19KW.

Enzyme and pathway databases

UniPathwayi UPA01003 .
BioCyci BAMY326423:GCM4-1689-MONOMER.

Family and domain databases

Gene3Di 3.40.366.10. 2 hits.
InterProi IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR004410. Malonyl_CoA-ACP_transAc_FabD.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF000446. Mct. 1 hit.
SUPFAMi SSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
TIGRFAMsi TIGR00128. fabD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 23117 / BGSC 10A6 / FZB42.
  2. "Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42."
    Chen X.-H., Vater J., Piel J., Franke P., Scholz R., Schneider K., Koumoutsi A., Hitzeroth G., Grammel N., Strittmatter A.W., Gottschalk G., Suessmuth R.D., Borriss R.
    J. Bacteriol. 188:4024-4036(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PATHWAY, FUNCTION IN BACILLAENE BIOSYNTHESIS.

Entry informationi

Entry nameiBAEC_BACA2
AccessioniPrimary (citable) accession number: A7Z4X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: October 23, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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