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Protein

8-amino-7-oxononanoate synthase 1

Gene

RBAM_016840

Organism
Bacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.By similarity

Catalytic activityi

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].

Cofactori

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331SubstrateBy similarity
Binding sitei180 – 1801Pyridoxal phosphateBy similarity
Binding sitei353 – 3531SubstrateBy similarity

GO - Molecular functioni

  1. 8-amino-7-oxononanoate synthase activity Source: UniProtKB
  2. glycine C-acetyltransferase activity Source: UniProtKB
  3. pyridoxal phosphate binding Source: UniProtKB

GO - Biological processi

  1. biotin biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBAMY326423:GCM4-1682-MONOMER.
UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
8-amino-7-oxononanoate synthase 1 (EC:2.3.1.47)
Short name:
AONS
Alternative name(s):
7-keto-8-amino-pelargonic acid synthase
Short name:
7-KAP synthase
Short name:
KAPA synthase
8-amino-7-ketopelargonate synthase
Alpha-oxoamine synthase
Gene namesi
Ordered Locus Names:RBAM_016840
OrganismiBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001120: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3913918-amino-7-oxononanoate synthase 1PRO_0000380903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei239 – 2391N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi326423.RBAM_016840.

Structurei

3D structure databases

ProteinModelPortaliA7Z4X1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni108 – 1092Pyridoxal phosphate bindingBy similarity
Regioni205 – 2084Pyridoxal phosphate bindingBy similarity
Regioni236 – 2394Pyridoxal phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000221022.
KOiK00639.
OMAiKEAGARH.
OrthoDBiEOG6Q8HZD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR010962. AONS_Archaea/Firmicutes.
IPR004723. AONS_Archaea/Proteobacteria.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00858. bioF. 1 hit.
TIGR01825. gly_Cac_T_rel. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7Z4X1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEFEFLKAE LDKMKENKTW QQMKQIETKQ GPSVEVKGEN VIQLSSNNYL
60 70 80 90 100
GLTSHPRLVE AAKRAAEEFG AGTGSVRTIA GTFTMHNELE KKLANFKKTE
110 120 130 140 150
AALVFQSGFT TNQGVLSSIL TKEDIVISDE LNHASIIDGI RLTKADKKVY
160 170 180 190 200
RHVDMDDLER VLKKSMNYRM RLIVTDGVFS MDGNIAPLPD IVKLAEAYDA
210 220 230 240 250
FVMVDDAHAS GVLGKNGRGT VNHFGLDGRV HIQVGTLSKA IGVLGGYAAG
260 270 280 290 300
SQVLIDYLRH KGRPFLFSTS HPPAVTAACI EAIDVLLEEP EHMEKLWENT
310 320 330 340 350
AYFKDKLVQM GLTLTKSETP IVPILIGEEE KAQALSDLLL TRGVFAQSIV
360 370 380 390
YPTVAQGKAR IRTIITAEHT NEELDRALEV IRSAAKELQL V
Length:391
Mass (Da):43,176
Last modified:October 23, 2007 - v1
Checksum:iB0A106263B61C6C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA. Translation: ABS74047.1.
RefSeqiYP_001421278.1. NC_009725.1.

Genome annotation databases

EnsemblBacteriaiABS74047; ABS74047; RBAM_016840.
GeneIDi5462068.
KEGGibay:RBAM_016840.
PATRICi18748436. VBIBacAmy31356_1694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA. Translation: ABS74047.1.
RefSeqiYP_001421278.1. NC_009725.1.

3D structure databases

ProteinModelPortaliA7Z4X1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326423.RBAM_016840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS74047; ABS74047; RBAM_016840.
GeneIDi5462068.
KEGGibay:RBAM_016840.
PATRICi18748436. VBIBacAmy31356_1694.

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000221022.
KOiK00639.
OMAiKEAGARH.
OrthoDBiEOG6Q8HZD.

Enzyme and pathway databases

UniPathwayiUPA00078.
BioCyciBAMY326423:GCM4-1682-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR010962. AONS_Archaea/Firmicutes.
IPR004723. AONS_Archaea/Proteobacteria.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00858. bioF. 1 hit.
TIGR01825. gly_Cac_T_rel. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 23117 / BGSC 10A6 / FZB42.

Entry informationi

Entry nameiBIOF1_BACA2
AccessioniPrimary (citable) accession number: A7Z4X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 23, 2007
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.