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A7Z4X1 (BIOF1_BACA2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
8-amino-7-oxononanoate synthase 1

Short name=AONS
EC=2.3.1.47
Alternative name(s):
7-keto-8-amino-pelargonic acid synthase
Short name=7-KAP synthase
Short name=KAPA synthase
8-amino-7-ketopelargonate synthase
Alpha-oxoamine synthase
Gene names
Ordered Locus Names:RBAM_016840
OrganismBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42) [Complete proteome] [HAMAP]
Taxonomic identifier326423 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide By similarity.

Catalytic activity

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Cofactor biosynthesis; biotin biosynthesis.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3913918-amino-7-oxononanoate synthase 1
PRO_0000380903

Regions

Region108 – 1092Pyridoxal phosphate binding By similarity
Region205 – 2084Pyridoxal phosphate binding By similarity
Region236 – 2394Pyridoxal phosphate binding By similarity

Sites

Binding site1331Substrate By similarity
Binding site1801Pyridoxal phosphate By similarity
Binding site3531Substrate By similarity

Amino acid modifications

Modified residue2391N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A7Z4X1 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: B0A106263B61C6C0

FASTA39143,176
        10         20         30         40         50         60 
MKEFEFLKAE LDKMKENKTW QQMKQIETKQ GPSVEVKGEN VIQLSSNNYL GLTSHPRLVE 

        70         80         90        100        110        120 
AAKRAAEEFG AGTGSVRTIA GTFTMHNELE KKLANFKKTE AALVFQSGFT TNQGVLSSIL 

       130        140        150        160        170        180 
TKEDIVISDE LNHASIIDGI RLTKADKKVY RHVDMDDLER VLKKSMNYRM RLIVTDGVFS 

       190        200        210        220        230        240 
MDGNIAPLPD IVKLAEAYDA FVMVDDAHAS GVLGKNGRGT VNHFGLDGRV HIQVGTLSKA 

       250        260        270        280        290        300 
IGVLGGYAAG SQVLIDYLRH KGRPFLFSTS HPPAVTAACI EAIDVLLEEP EHMEKLWENT 

       310        320        330        340        350        360 
AYFKDKLVQM GLTLTKSETP IVPILIGEEE KAQALSDLLL TRGVFAQSIV YPTVAQGKAR 

       370        380        390 
IRTIITAEHT NEELDRALEV IRSAAKELQL V 

« Hide

References

[1]"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42."
Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R.
Nat. Biotechnol. 25:1007-1014(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 23117 / BGSC 10A6 / FZB42.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000560 Genomic DNA. Translation: ABS74047.1.
RefSeqYP_001421278.1. NC_009725.1.

3D structure databases

ProteinModelPortalA7Z4X1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326423.RBAM_016840.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS74047; ABS74047; RBAM_016840.
GeneID5462068.
KEGGbay:RBAM_016840.
PATRIC18748436. VBIBacAmy31356_1694.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0156.
HOGENOMHOG000221022.
KOK00639.
OMAKEAGARH.
OrthoDBEOG6Q8HZD.
ProtClustDBPRK06939.

Enzyme and pathway databases

BioCycBAMY326423:GCM4-1682-MONOMER.
UniPathwayUPA00078.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR004723. BioF.
IPR010962. PyrdxlP-dep_AcTrfase_put.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR00858. bioF. 1 hit.
TIGR01825. gly_Cac_T_rel. 1 hit.
PROSITEPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBIOF1_BACA2
AccessionPrimary (citable) accession number: A7Z4X1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 23, 2007
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways