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A7Z4X1

- BIOF1_BACA2

UniProt

A7Z4X1 - BIOF1_BACA2

Protein

8-amino-7-oxononanoate synthase 1

Gene

RBAM_016840

Organism
Bacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.By similarity

    Catalytic activityi

    Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei133 – 1331SubstrateBy similarity
    Binding sitei180 – 1801Pyridoxal phosphateBy similarity
    Binding sitei353 – 3531SubstrateBy similarity

    GO - Molecular functioni

    1. 8-amino-7-oxononanoate synthase activity Source: UniProtKB
    2. glycine C-acetyltransferase activity Source: UniProtKB
    3. pyridoxal phosphate binding Source: UniProtKB

    GO - Biological processi

    1. biotin biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Biotin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBAMY326423:GCM4-1682-MONOMER.
    UniPathwayiUPA00078.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    8-amino-7-oxononanoate synthase 1 (EC:2.3.1.47)
    Short name:
    AONS
    Alternative name(s):
    7-keto-8-amino-pelargonic acid synthase
    Short name:
    7-KAP synthase
    Short name:
    KAPA synthase
    8-amino-7-ketopelargonate synthase
    Alpha-oxoamine synthase
    Gene namesi
    Ordered Locus Names:RBAM_016840
    OrganismiBacillus amyloliquefaciens subsp. plantarum (strain DSM 23117 / BGSC 10A6 / FZB42)
    Taxonomic identifieri326423 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001120: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3913918-amino-7-oxononanoate synthase 1PRO_0000380903Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei239 – 2391N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi326423.RBAM_016840.

    Structurei

    3D structure databases

    ProteinModelPortaliA7Z4X1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni108 – 1092Pyridoxal phosphate bindingBy similarity
    Regioni205 – 2084Pyridoxal phosphate bindingBy similarity
    Regioni236 – 2394Pyridoxal phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0156.
    HOGENOMiHOG000221022.
    KOiK00639.
    OMAiKEAGARH.
    OrthoDBiEOG6Q8HZD.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR010962. AONS_Archaea/Firmicutes.
    IPR004723. AONS_Archaea/Proteobacteria.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00858. bioF. 1 hit.
    TIGR01825. gly_Cac_T_rel. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7Z4X1-1 [UniParc]FASTAAdd to Basket

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    MKEFEFLKAE LDKMKENKTW QQMKQIETKQ GPSVEVKGEN VIQLSSNNYL    50
    GLTSHPRLVE AAKRAAEEFG AGTGSVRTIA GTFTMHNELE KKLANFKKTE 100
    AALVFQSGFT TNQGVLSSIL TKEDIVISDE LNHASIIDGI RLTKADKKVY 150
    RHVDMDDLER VLKKSMNYRM RLIVTDGVFS MDGNIAPLPD IVKLAEAYDA 200
    FVMVDDAHAS GVLGKNGRGT VNHFGLDGRV HIQVGTLSKA IGVLGGYAAG 250
    SQVLIDYLRH KGRPFLFSTS HPPAVTAACI EAIDVLLEEP EHMEKLWENT 300
    AYFKDKLVQM GLTLTKSETP IVPILIGEEE KAQALSDLLL TRGVFAQSIV 350
    YPTVAQGKAR IRTIITAEHT NEELDRALEV IRSAAKELQL V 391
    Length:391
    Mass (Da):43,176
    Last modified:October 23, 2007 - v1
    Checksum:iB0A106263B61C6C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000560 Genomic DNA. Translation: ABS74047.1.
    RefSeqiYP_001421278.1. NC_009725.1.

    Genome annotation databases

    EnsemblBacteriaiABS74047; ABS74047; RBAM_016840.
    GeneIDi5462068.
    KEGGibay:RBAM_016840.
    PATRICi18748436. VBIBacAmy31356_1694.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000560 Genomic DNA. Translation: ABS74047.1 .
    RefSeqi YP_001421278.1. NC_009725.1.

    3D structure databases

    ProteinModelPortali A7Z4X1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326423.RBAM_016840.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS74047 ; ABS74047 ; RBAM_016840 .
    GeneIDi 5462068.
    KEGGi bay:RBAM_016840.
    PATRICi 18748436. VBIBacAmy31356_1694.

    Phylogenomic databases

    eggNOGi COG0156.
    HOGENOMi HOG000221022.
    KOi K00639.
    OMAi KEAGARH.
    OrthoDBi EOG6Q8HZD.

    Enzyme and pathway databases

    UniPathwayi UPA00078 .
    BioCyci BAMY326423:GCM4-1682-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR010962. AONS_Archaea/Firmicutes.
    IPR004723. AONS_Archaea/Proteobacteria.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00858. bioF. 1 hit.
    TIGR01825. gly_Cac_T_rel. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 23117 / BGSC 10A6 / FZB42.

    Entry informationi

    Entry nameiBIOF1_BACA2
    AccessioniPrimary (citable) accession number: A7Z4X1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3