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Protein

8-amino-7-oxononanoate synthase 1

Gene

RBAM_016840

Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.By similarity

Catalytic activityi

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].

Cofactori

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133SubstrateBy similarity1
Binding sitei180Pyridoxal phosphateBy similarity1
Binding sitei353SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processBiotin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciBAMY326423:G1G84-1716-MONOMER
UniPathwayiUPA00078

Names & Taxonomyi

Protein namesi
Recommended name:
8-amino-7-oxononanoate synthase 1 (EC:2.3.1.47)
Short name:
AONS
Alternative name(s):
7-keto-8-amino-pelargonic acid synthase
Short name:
7-KAP synthase
Short name:
KAPA synthase
8-amino-7-ketopelargonate synthase
Alpha-oxoamine synthase
Gene namesi
Ordered Locus Names:RBAM_016840
OrganismiBacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus amyloliquefaciens group
Proteomesi
  • UP000001120 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003809031 – 3918-amino-7-oxononanoate synthase 1Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei239N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliA7Z4X1
SMRiA7Z4X1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 109Pyridoxal phosphate bindingBy similarity2
Regioni205 – 208Pyridoxal phosphate bindingBy similarity4
Regioni236 – 239Pyridoxal phosphate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107EEK Bacteria
COG0156 LUCA
HOGENOMiHOG000221022
KOiK00639
OMAiFGTIGEN

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR010962 AONS_Archaea/Firmicutes
IPR004723 AONS_Archaea/Proteobacteria
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00858 bioF, 1 hit
TIGR01825 gly_Cac_T_rel, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

A7Z4X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEFEFLKAE LDKMKENKTW QQMKQIETKQ GPSVEVKGEN VIQLSSNNYL
60 70 80 90 100
GLTSHPRLVE AAKRAAEEFG AGTGSVRTIA GTFTMHNELE KKLANFKKTE
110 120 130 140 150
AALVFQSGFT TNQGVLSSIL TKEDIVISDE LNHASIIDGI RLTKADKKVY
160 170 180 190 200
RHVDMDDLER VLKKSMNYRM RLIVTDGVFS MDGNIAPLPD IVKLAEAYDA
210 220 230 240 250
FVMVDDAHAS GVLGKNGRGT VNHFGLDGRV HIQVGTLSKA IGVLGGYAAG
260 270 280 290 300
SQVLIDYLRH KGRPFLFSTS HPPAVTAACI EAIDVLLEEP EHMEKLWENT
310 320 330 340 350
AYFKDKLVQM GLTLTKSETP IVPILIGEEE KAQALSDLLL TRGVFAQSIV
360 370 380 390
YPTVAQGKAR IRTIITAEHT NEELDRALEV IRSAAKELQL V
Length:391
Mass (Da):43,176
Last modified:October 23, 2007 - v1
Checksum:iB0A106263B61C6C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA Translation: ABS74047.1
RefSeqiWP_012117584.1, NC_009725.1

Genome annotation databases

EnsemblBacteriaiABS74047; ABS74047; RBAM_016840
KEGGibay:RBAM_016840

Similar proteinsi

Entry informationi

Entry nameiBIOF1_BACVZ
AccessioniPrimary (citable) accession number: A7Z4X1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 23, 2007
Last modified: April 25, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health