Reviewed, UniProtKB/Swiss-Prot A7Z4G9 (PYRB_BACA2)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	RBAM_015320

Organism

Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]

Taxonomic identifier

326423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000000001

Sequences

	Sequence		Length	Mass (Da)
	A7Z4G9-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 58E150D0BF856124	FASTA	304	33,812
	10 20 30 40 50 60 MNHLTAMSEL SAAEITELLR EAKAIKEGTV RHDLAGKFVA NLFFEPSTRT RFSFEVAEKK 70 80 90 100 110 120 LGMNVLSLDD TSTSVQKGES LYDTVKTLES IGADACVIRH STDEYYKDLT GRVNIPILNA 130 140 150 160 170 180 GDGCGQHPTQ SLLDLMTIQE EFETFQGLTV SIHGDIKHSR VARSNAEVLT RLGARVLFSG 190 200 210 220 230 240 PPQWQDEKNA FGTCVQTDEA IQASDVVMLL RIQNERHQTE ADQKGYLEAY GLTAKRAESM 250 260 270 280 290 300 KRHAIIMHPA PVNRGVEIDT TLVECGKSRI FKQMENGVYI RMAVLKRALQ TNVKRGEAAY VLSH

References

[1]

"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000560 Genomic DNA. Translation: ABS73895.1.
RefSeq	YP_001421126.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7Z4G9.
Genome annotation databases
GeneID	5462418.
GenomeReviews	Gene locus RBAM_015320 in contig CP000560_GR.
KEGG	bay:RBAM_015320.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RTVVNLF.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BACA2

Accession

Primary (citable) accession number: A7Z4G9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	November 3, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)