Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene

murD

Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).UniRule annotation

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi120 – 126ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAMY326423:G1G84-1535-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
Alternative name(s):
D-glutamic acid-adding enzymeUniRule annotation
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUniRule annotation
Gene namesi
Name:murDUniRule annotation
Ordered Locus Names:RBAM_015060
OrganismiBacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus amyloliquefaciens group
Proteomesi
  • UP000001120 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000568721 – 451UDP-N-acetylmuramoylalanine--D-glutamate ligaseAdd BLAST451

Structurei

3D structure databases

ProteinModelPortaliA7Z4E3
SMRiA7Z4E3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DMZ Bacteria
COG0771 LUCA
HOGENOMiHOG000049428
KOiK01925
OMAiVDKGNDY

Family and domain databases

Gene3Di3.40.1190.10, 1 hit
3.90.190.20, 1 hit
HAMAPiMF_00639 MurD, 1 hit
InterProiView protein in InterPro
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR005762 UDP-N-AcMur-Glu_ligase
PfamiView protein in Pfam
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
TIGRFAMsiTIGR01087 murD, 1 hit

Sequencei

Sequence statusi: Complete.

A7Z4E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENELFLQKQ NFLVLGLAKS GYAAASILHE KGINVVVNDQ KAFEENEPAQ
60 70 80 90 100
RLAERGIEVI CGEHPTSLFD QHHITILIKN PGIPYENIMV EEAQRRGIPV
110 120 130 140 150
WTEIELAYYI TNAKFIGITG SNGKTTTTTL IYEMLKADSI KTLIAGNIGT
160 170 180 190 200
VASEVAYHAD GDEWIVTELS SFQLMGTHAF RPEIGLILNV FDAHLDYHHS
210 220 230 240 250
RENYEKAKQN VYLHQLESDT AIVNQSDETV VRLAESGKAG TVPFSVHQEL
260 270 280 290 300
SSGAFIKDGM LMFGDEAILP VDDIVLPGAH NLENILAAVA AAKTAGASNK
310 320 330 340 350
AIQKVLTSFT GVKHRLQYVT AIQNRKFYND SKATNILATS KALSAFKAPV
360 370 380 390 400
ILLAGGLDRG NGFDDLKPYM DNVKAVLTFG QTAPKIEKLG NELGIQHVKR
410 420 430 440 450
VDNVEQAVSA AFALSNEGDV ILLSPACASW DQFKTFEERG DMFIDAVHML

K
Length:451
Mass (Da):49,443
Last modified:October 23, 2007 - v1
Checksum:iC2AA5E4EE1765896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA Translation: ABS73869.1
RefSeqiWP_012117504.1, NC_009725.1

Genome annotation databases

EnsemblBacteriaiABS73869; ABS73869; RBAM_015060
KEGGibay:RBAM_015060

Similar proteinsi

Entry informationi

Entry nameiMURD_BACVZ
AccessioniPrimary (citable) accession number: A7Z4E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health