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Reviewed, UniProtKB/Swiss-Prot A7Z323 (DCUP_BACA2)

Last modified February 9, 2010. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37
Gene names
Name: hemE
Ordered Locus Names: RBAM_010350
OrganismBacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]
Taxonomic identifier326423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

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Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000325625

Regions

Region29 – 335Substrate binding By similarity

Sites

Binding site781Substrate By similarity
Binding site1541Substrate By similarity
Binding site2091Substrate By similarity
Binding site3221Substrate By similarity
Site781Transition state stabilizer By similarity

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Sequences

Sequence LengthMass (Da)Tools
A7Z323-1 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 973AB3FAB9A09951

FASTA35339,621
        10         20         30         40         50         60 
MSKREAFNDT FLKAARGEKT NHVPVWYMRQ AGRSQPEYRK LKEKYGLVEI THQPELCAYV 

        70         80         90        100        110        120 
TRLPVEQYGV DAAILYKDIM TPLPYIGVDV EIKNGIGPVI DQPVRSAADI EKLGELNPEQ 

       130        140        150        160        170        180 
DVPYVLETIR LLVNEQLNVP LIGFSGAPFT LASYMIEGGP SKNYNKTKAF MHSMPQAWKM 

       190        200        210        220        230        240 
LMDKLADMII VYAKAQINAG AKAIQIFDSW VGALNREDYR QFIKPVMDRI FRELSAEQVP 

       250        260        270        280        290        300 
LIMFGVGASH LAGDWHDLPL DVVGLDWRLG IDDARKQGIT KTVQGNLDPS LLLAPWEVIE 

       310        320        330        340        350 
KKAKAILDQG MKTDGFIFNL GHGVFPDVNP ETLKKLTAFV HEYSAAKKTE QSS

« Hide

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References

[1]"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42."
Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R.
Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000560 Genomic DNA. Translation: ABS73399.1.
RefSeqYP_001420630.1.

3D structure databases

SMRA7Z323. Positions 7-348.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7Z323.

Genome annotation databases

GeneID5461429.
GenomeReviewsGene locus RBAM_010350 in contig CP000560_GR.
KEGGbay:RBAM_010350.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAQIFDTWG.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDCUP_BACA2
AccessionPrimary (citable) accession number: A7Z323
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 23, 2007
Last modified: February 9, 2010
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents