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Protein

Serine-protein kinase RsbW

Gene

rsbW

Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-protein kinase RsbWUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Anti-sigma-B factorUniRule annotation
Sigma-B negative effector RsbWUniRule annotation
Gene namesi
Name:rsbWUniRule annotation
Ordered Locus Names:RBAM_005060
OrganismiBacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus amyloliquefaciens group
Proteomesi
  • UP000001120 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000614461 – 160Serine-protein kinase RsbWAdd BLAST160

Structurei

3D structure databases

ProteinModelPortaliA7Z1M9
SMRiA7Z1M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBE Bacteria
COG2172 LUCA
HOGENOMiHOG000269932
KOiK04757
OMAiKMGFSYE

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
HAMAPiMF_00638 Anti_sigma_B, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR010193 RsbW
PfamiView protein in Pfam
PF13581 HATPase_c_2, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR01924 rsbW_low_gc, 1 hit

Sequencei

Sequence statusi: Complete.

A7Z1M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSVDYIEM KIPAEPEYVG IVRLTLSGVA SRMGYTYDDI EDLKIAVSEA
60 70 80 90 100
CTNAVQHAYN DENKGEVSVR FGVFEDRLEV IVADQGDSFD FDQKQQDLGP
110 120 130 140 150
YTPSHTVDQL SEGGLGLYLM ETLMDEVKVQ SNSGVTVAMT KYLNGERVDH
160
GTTIKNYETN
Length:160
Mass (Da):17,762
Last modified:October 23, 2007 - v1
Checksum:i81B667B91D5C9238
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA Translation: ABS72905.1
RefSeqiWP_007609591.1, NC_009725.1

Genome annotation databases

EnsemblBacteriaiABS72905; ABS72905; RBAM_005060
KEGGibay:RBAM_005060

Similar proteinsi

Entry informationi

Entry nameiRSBW_BACVZ
AccessioniPrimary (citable) accession number: A7Z1M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health