ID   MTLD_BACA2              Reviewed;         373 AA.
AC   A7Z1E8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   16-JUN-2009, entry version 14.
DE   RecName: Full=Mannitol-1-phosphate 5-dehydrogenase;
DE            EC=1.1.1.17;
GN   Name=mtlD; OrderedLocusNames=RBAM_004250;
OS   Bacillus amyloliquefaciens (strain FZB42).
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=326423;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17704766; DOI=10.1038/nbt1325;
RA   Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K.,
RA   Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H.,
RA   Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H.,
RA   Strittmatter A., Gottschalk G., Borriss R.;
RT   "Comparative analysis of the complete genome sequence of the plant
RT   growth-promoting bacterium Bacillus amyloliquefaciens FZB42.";
RL   Nat. Biotechnol. 25:1007-1014(2007).
CC   -!- CATALYTIC ACTIVITY: D-mannitol 1-phosphate + NAD(+) = D-fructose
CC       6-phosphate + NADH.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family.
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DR   EMBL; CP000560; ABS72824.1; -; Genomic_DNA.
DR   RefSeq; YP_001420055.1; -.
DR   GeneID; 5459968; -.
DR   GenomeReviews; CP000560_GR; RBAM_004250.
DR   KEGG; bay:RBAM_004250; -.
DR   OMA; A7Z1E8; VDRIVPN.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0008926; F:mannitol-1-phosphate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00196; -; 1.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR000669; Mannitol_DH_core.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    373       Mannitol-1-phosphate 5-dehydrogenase.
FT                                /FTId=PRO_1000011794.
FT   NP_BIND       3     14       NAD (By similarity).
SQ   SEQUENCE   373 AA;  41164 MW;  50DF9BE1E9D5B33A CRC64;
     MIALHFGAGN IGRGFIGALL HHSGYDVVFA DVNETMVSLL NEKKEYTVEL ADGGRQTEII
     GPVSAINSAV QEQKLYRLIN EAAIITTAVG PNVLRLIAPS IAEGLKRRTS SEPLNIIACE
     NMIGGSSFLK KAVFGHLTEA ERELVNRTVG FPDSAVDRIV PIQHHEDPLK VSVEPFFEWV
     IDRTGFAGGQ PVLKGALFTD DLTPFIERKL FTVNTGHAVT AYVGYQRGLK TVKEAIGHPE
     IRRVVYDALS ETGEYLVKAY GFKQSEHEQY MKKIIGRFEN EYITDDVTRV ARSPLRKLGA
     NDRLVGPAKK IKEPNALAEG IAAALRFDYQ DDPEAVELQK LIAEKGTSRV LQDICGIQLH
     EPLHGIVLKK LNQ
//