Reviewed, UniProtKB/Swiss-Prot A7Z1E8 (MTLD_BACA2)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	RBAM_004250

Organism

Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]

Taxonomic identifier

326423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 373	373	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000011794
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7Z1E8-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 50DF9BE1E9D5B33A	FASTA	373	41,164
	10 20 30 40 50 60 MIALHFGAGN IGRGFIGALL HHSGYDVVFA DVNETMVSLL NEKKEYTVEL ADGGRQTEII 70 80 90 100 110 120 GPVSAINSAV QEQKLYRLIN EAAIITTAVG PNVLRLIAPS IAEGLKRRTS SEPLNIIACE 130 140 150 160 170 180 NMIGGSSFLK KAVFGHLTEA ERELVNRTVG FPDSAVDRIV PIQHHEDPLK VSVEPFFEWV 190 200 210 220 230 240 IDRTGFAGGQ PVLKGALFTD DLTPFIERKL FTVNTGHAVT AYVGYQRGLK TVKEAIGHPE 250 260 270 280 290 300 IRRVVYDALS ETGEYLVKAY GFKQSEHEQY MKKIIGRFEN EYITDDVTRV ARSPLRKLGA 310 320 330 340 350 360 NDRLVGPAKK IKEPNALAEG IAAALRFDYQ DDPEAVELQK LIAEKGTSRV LQDICGIQLH 370 EPLHGIVLKK LNQ

References

[1]

"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000560 Genomic DNA. Translation: ABS72824.1.
RefSeq	YP_001420055.1.
3D structure databases
SMR	A7Z1E8. Positions 3-359.
ModBase	Search...
Protein-protein interaction databases
STRING	A7Z1E8.
Genome annotation databases
GeneID	5459968.
GenomeReviews	Gene locus RBAM_004250 in contig CP000560_GR.
KEGG	bay:RBAM_004250.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0246.
HOGENOM	HBG568825.
OMA	VDRIVPN.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_BACA2

Accession

Primary (citable) accession number: A7Z1E8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	January 19, 2010
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)