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A7Z1E8 (MTLD_BACA2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:RBAM_004250
OrganismBacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]
Taxonomic identifier326423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000011794

Regions

Nucleotide binding3 – 1412NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A7Z1E8 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 50DF9BE1E9D5B33A

FASTA37341,164
        10         20         30         40         50         60 
MIALHFGAGN IGRGFIGALL HHSGYDVVFA DVNETMVSLL NEKKEYTVEL ADGGRQTEII 

        70         80         90        100        110        120 
GPVSAINSAV QEQKLYRLIN EAAIITTAVG PNVLRLIAPS IAEGLKRRTS SEPLNIIACE 

       130        140        150        160        170        180 
NMIGGSSFLK KAVFGHLTEA ERELVNRTVG FPDSAVDRIV PIQHHEDPLK VSVEPFFEWV 

       190        200        210        220        230        240 
IDRTGFAGGQ PVLKGALFTD DLTPFIERKL FTVNTGHAVT AYVGYQRGLK TVKEAIGHPE 

       250        260        270        280        290        300 
IRRVVYDALS ETGEYLVKAY GFKQSEHEQY MKKIIGRFEN EYITDDVTRV ARSPLRKLGA 

       310        320        330        340        350        360 
NDRLVGPAKK IKEPNALAEG IAAALRFDYQ DDPEAVELQK LIAEKGTSRV LQDICGIQLH 

       370 
EPLHGIVLKK LNQ

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References

[1]"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42."
Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R.
Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FZB42.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000560 Genomic DNA. Translation: ABS72824.1.
RefSeqYP_001420055.1. NC_009725.1.

3D structure databases

ProteinModelPortalA7Z1E8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7Z1E8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000005427; EBBACP00000005305; EBBACG00000005419.
GeneID5459968.
GenomeReviewsGene locus RBAM_004250 in contig CP000560_GR.
KEGGbay:RBAM_004250.
PATRIC18745766. VBIBacAmy31356_0395.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0246.
GeneTreeEBGT00050000001216.
HOGENOMHBG568825.
OMAFANTAVD.
ProtClustDBPRK02318.

Enzyme and pathway databases

BioCycBAMY326423:RBAM_004250-MONOMER.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_BACA2
AccessionPrimary (citable) accession number: A7Z1E8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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