A7Z0C9 (A7Z0C9_BACA2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL ABS72455.1
Ordered Locus Names:	RBAM_000070

Organism

Bacillus amyloliquefaciens (strain FZB42) [Complete proteome] [HAMAP]

Taxonomic identifier

326423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	793 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A7Z0C9 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 403C6AC24EE36342	FASTA	793	88,757
	10 20 30 40 50 60 MSVIVSRALP DVRDGLKPVH RRILYAMNDL GMTSDKPYKK SARIVGEVIG KYHPHGDSAV 70 80 90 100 110 120 YESMVRMAQD FNYRYMLVDG HGNFGSVDGD SAAAMRYTEA RMSKIAMEIL RDITKDTIDY 130 140 150 160 170 180 QDNYDGAERE PVVMPSRFPN LLVNGAAGIA VGMATNIPPH QLGEVIEGVL AVSENPEITN 190 200 210 220 230 240 QELMEYIPGP DFPTAGQILG RSGIRKAYES GRGSITIRAK AEIEETSSGK ERIIVTELPY 250 260 270 280 290 300 QVNKARLIEK IADLVRDKKI EGITDLRDES DRNGMRIVIE IRRDANAHVI LNNLYKQTAL 310 320 330 340 350 360 QTSFGINLLA LVDGQPKVLS LKQCLEHYLD HQKVVIRRRT AYELRKAEAR AHILEGLRIA 370 380 390 400 410 420 LDHLDAVISL IRNSQTAEIA RTGLIEQFSL TEKQAQAILD MRLQRLTGLE REKIEEEYQS 430 440 450 460 470 480 LVALIAELKD ILANEARVLE IIREELNEIK ERFNDERRTE IVTSGLETIE DEDLIERENI 490 500 510 520 530 540 VITLTHNGYV KRLPASTYRS QKRGGKGVQG MGTNEDDFVE HLISTSTHDT ILFFSNKGKV 550 560 570 580 590 600 YRSKGYEIPE YGRTAKGIPI INLLEVEKGE WINAIIPVST FDEEQYLFFT TKQGVSKRTA 610 620 630 640 650 660 LSQFANIRNN GLIALGLRED DELMAVRLTD GKKQIIIGTK NGLLIRFPEE DVRQMGRTAA 670 680 690 700 710 720 GVKGITLTDD DVVVGMEILE EDSHVLIVTE NGYGKRTPAS EYRVQSRGGK GLKTCKITDS 730 740 750 760 770 780 NGPLVTVKAT KGEEDLMIIT ASGVLIRMDI NDISTTGRVT QGVRLIRMSD QEHVATVALV 790 EKNEEEPEET EEV

References

[1]

"Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42." Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K., Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H., Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H., Strittmatter A., Gottschalk G., Borriss R. Nat. Biotechnol. 25:1007-1014(2007) [PubMed: 17704766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000560 Genomic DNA. Translation: ABS72455.1.
RefSeq	YP_001419686.1. NC_009725.1.
3D structure databases
ProteinModelPortal	A7Z0C9.
SMR	A7Z0C9. Positions 5-461.
ModBase	Search...
Protein-protein interaction databases
STRING	A7Z0C9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000005865; EBBACP00000005743; EBBACG00000005857.
GeneID	5461733.
GenomeReviews	Gene locus RBAM_000070 in contig CP000560_GR.
KEGG	bay:RBAM_000070.
PATRIC	18744907. VBIBacAmy31356_0007.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
GeneTree	EBGT00050000002933.
HOGENOM	HBG635183.
OMA	TSIPPHR.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A7Z0C9_BACA2

Accession

Primary (citable) accession number: A7Z0C9

Entry history

Integrated into UniProtKB/TrEMBL:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)