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Protein

Cell division cycle protein 27 homolog

Gene

CDC27

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-BTA-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-BTA-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-BTA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-BTA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-BTA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-BTA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-BTA-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-BTA-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-BTA-176409. APC/C:Cdc20 mediated degradation of mitotic proteins.
R-BTA-176412. Phosphorylation of the APC/C.
R-BTA-179409. APC-Cdc20 mediated degradation of Nek2A.
R-BTA-2467813. Separation of Sister Chromatids.
R-BTA-2559582. Senescence-Associated Secretory Phenotype (SASP).
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle protein 27 homolog
Gene namesi
Name:CDC27
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003904721 – 825Cell division cycle protein 27 homologAdd BLAST825

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205PhosphothreonineBy similarity1
Modified residuei209PhosphothreonineBy similarity1
Modified residuei244PhosphothreonineBy similarity1
Modified residuei291PhosphoserineBy similarity1
Modified residuei313PhosphothreonineBy similarity1
Modified residuei339PhosphoserineBy similarity1
Modified residuei367PhosphothreonineBy similarity1
Modified residuei380PhosphoserineBy similarity1
Modified residuei387PhosphoserineBy similarity1
Modified residuei427PhosphoserineBy similarity1
Modified residuei431PhosphothreonineBy similarity1
Modified residuei436PhosphoserineBy similarity1
Modified residuei439PhosphoserineBy similarity1
Modified residuei447PhosphothreonineBy similarity1
Modified residuei822PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation on Ser-427 and Thr-447 occurs specifically during mitosis (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA7Z061.
PRIDEiA7Z061.

Expressioni

Gene expression databases

BgeeiENSBTAG00000002726.

Interactioni

Subunit structurei

Homodimer. The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Interacts with RB (By similarity). Interacts with MCPH1 (By similarity). Interacts with FAM168B/MANI (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003533.

Structurei

3D structure databases

ProteinModelPortaliA7Z061.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 35TPR 1Add BLAST30
Repeati38 – 65TPR 2Add BLAST28
Repeati67 – 99TPR 3Add BLAST33
Repeati115 – 145TPR 4Add BLAST31
Repeati465 – 495TPR 5Add BLAST31
Repeati499 – 528TPR 6Add BLAST30
Repeati533 – 563TPR 7Add BLAST31
Repeati567 – 598TPR 8Add BLAST32
Repeati601 – 631TPR 9Add BLAST31
Repeati635 – 667TPR 10Add BLAST33
Repeati670 – 702TPR 11Add BLAST33
Repeati704 – 734TPR 12Add BLAST31
Repeati737 – 768TPR 13Add BLAST32

Sequence similaritiesi

Belongs to the APC3/CDC27 family.Curated
Contains 13 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1126. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00550000074887.
HOGENOMiHOG000231056.
HOVERGENiHBG050859.
InParanoidiA7Z061.
KOiK03350.
OMAiNSCTTQV.
OrthoDBiEOG091G03JF.
TreeFamiTF101058.

Family and domain databases

InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 2 hits.
PF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 8 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 8 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7Z061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVLQEPVQA AIWQALNHYA YRDAVFLAER LYAEVHSEEA LFLLATCYYR
60 70 80 90 100
SGKAYKAYRL LKGHSCTTPQ CKYLLAKCCV DLSKLAEGEQ ILSGGVFNKQ
110 120 130 140 150
KSHDDIVTEF GDSACFTLSL LGHVYCKTDR LAKGSECYQK SLSLNPFLWS
160 170 180 190 200
PFESLCEIGE KPDPDQTFKL TSLQNFSSCL PNSCTTLVSN HSLSHRQPET
210 220 230 240 250
VLTETPQDTI ELNRLNLESS NSKYSLNTDS SVSYIDSAVI SPDTVPLGTG
260 270 280 290 300
TSILSKQVQN KPKTGRSLLG GPAALSPLTP SFGILPLETP SPGDGSYLQN
310 320 330 340 350
YTNTSSVIDV PPTGAPSKKS VARIGQTGTK SVFSQSGNSR EVTPILVAQT
360 370 380 390 400
QSSGPQTSTT PQVLSPTITS PPNALPRRSS RLFTSDSSTT KENSKKLKMK
410 420 430 440 450
FPPKIPNRKT KSKTNKGGIT QPNINDSLEI TKLDSSIISE GKISTITPQI
460 470 480 490 500
QAFNLQKAAA EGLMSLLREM GKGYLALCSY NCKEAINILS HLPSHHYNTG
510 520 530 540 550
WVLCQIGRAY FELSEYMQAE RIFSEVRRIE NYRVEGMEIY STTLWHLQKD
560 570 580 590 600
VALSVLSKDL TDMDKNSPEA WCAAGNCFSL QREHDIAIKF FQRAIQVDPN
610 620 630 640 650
YAYAYTLLGH EFVLTEELDK ALACFRNAIR VNPRHYNAWY GLGMIYYKQE
660 670 680 690 700
KFSLAEMHFQ KALDINPQSS VLLCHIGVVQ HALKKSEKAL DTLNKAIVID
710 720 730 740 750
PKNPLCKFHR ASVLFANEKY KSALQELEEL KQIVPKESLV YFLIGKVYKK
760 770 780 790 800
LGQTHLALMN FSWAMDLDPK GANNQIKEAI DKRYLPDDEE PITQEEQIMG
810 820
TDESQESSMT DADDTQLHAA ESDEF
Length:825
Mass (Da):91,870
Last modified:October 23, 2007 - v1
Checksum:i4B2410577714FF9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC153259 mRNA. Translation: AAI53260.1.
RefSeqiNP_001098898.1. NM_001105428.1.
UniGeneiBt.65174.

Genome annotation databases

EnsembliENSBTAT00000003533; ENSBTAP00000003533; ENSBTAG00000002726.
GeneIDi540660.
KEGGibta:540660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC153259 mRNA. Translation: AAI53260.1.
RefSeqiNP_001098898.1. NM_001105428.1.
UniGeneiBt.65174.

3D structure databases

ProteinModelPortaliA7Z061.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003533.

Proteomic databases

PaxDbiA7Z061.
PRIDEiA7Z061.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003533; ENSBTAP00000003533; ENSBTAG00000002726.
GeneIDi540660.
KEGGibta:540660.

Organism-specific databases

CTDi996.

Phylogenomic databases

eggNOGiKOG1126. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00550000074887.
HOGENOMiHOG000231056.
HOVERGENiHBG050859.
InParanoidiA7Z061.
KOiK03350.
OMAiNSCTTQV.
OrthoDBiEOG091G03JF.
TreeFamiTF101058.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-BTA-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-BTA-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-BTA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-BTA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-BTA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-BTA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-BTA-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-BTA-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-BTA-176409. APC/C:Cdc20 mediated degradation of mitotic proteins.
R-BTA-176412. Phosphorylation of the APC/C.
R-BTA-179409. APC-Cdc20 mediated degradation of Nek2A.
R-BTA-2467813. Separation of Sister Chromatids.
R-BTA-2559582. Senescence-Associated Secretory Phenotype (SASP).

Gene expression databases

BgeeiENSBTAG00000002726.

Family and domain databases

InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 2 hits.
PF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 8 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 8 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDC27_BOVIN
AccessioniPrimary (citable) accession number: A7Z061
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: October 23, 2007
Last modified: October 5, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.