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Protein

Clathrin interactor 1

Gene

CLINT1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei67Phosphatidylinositol lipid headgroupBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processEndocytosis
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-BTA-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin interactor 1
Alternative name(s):
Epsin-4
Gene namesi
Name:CLINT1
Synonyms:EPN4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:27443 CLINT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003284931 – 643Clathrin interactor 1Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei163PhosphoserineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei210PhosphoserineBy similarity1
Modified residuei227PhosphoserineBy similarity1
Modified residuei245PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei308PhosphothreonineBy similarity1
Modified residuei312PhosphoserineBy similarity1
Modified residuei642PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA7Z035
PeptideAtlasiA7Z035
PRIDEiA7Z035

Expressioni

Gene expression databases

BgeeiENSBTAG00000016199

Interactioni

Subunit structurei

Binds clathrin heavy chain, GGA2, AP-2 and AP1G1. Interacts with VTI1B.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021559

Structurei

3D structure databases

ProteinModelPortaliA7Z035
SMRiA7Z035
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 149ENTHPROSITE-ProRule annotationAdd BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 54Interaction with VTI1BBy similarity3
Regioni94 – 96Interaction with VTI1BBy similarity3
Regioni142 – 153Interaction with VTI1BBy similarityAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi268 – 273Poly-Thr6
Compositional biasi524 – 628Met-richAdd BLAST105

Sequence similaritiesi

Belongs to the epsin family.Curated

Phylogenomic databases

eggNOGiKOG2056 Eukaryota
ENOG410XSM0 LUCA
GeneTreeiENSGT00550000074611
HOGENOMiHOG000082415
HOVERGENiHBG048921
InParanoidiA7Z035
OMAiNMQQPMN
OrthoDBiEOG091G0FWU
TreeFamiTF313361

Family and domain databases

Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR030544 CLINT1
IPR013809 ENTH
IPR008942 ENTH_VHS
PANTHERiPTHR12276:SF67 PTHR12276:SF67, 1 hit
PfamiView protein in Pfam
PF01417 ENTH, 1 hit
SMARTiView protein in SMART
SM00273 ENTH, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50942 ENTH, 1 hit

Sequencei

Sequence statusi: Complete.

A7Z035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNMWKVREL VDKATNVVMN YSEIESKVRE ATNDDPWGPS GQLMGEIAKA
60 70 80 90 100
TFMYEQFPEL MNMLWSRMLK DNKKNWRRVY KSLLLLAYLI RNGSERVVTS
110 120 130 140 150
AREHIYDLRS LENYHFVDEH GKDQGINIRQ KVKELVEFAQ DDDRLREERK
160 170 180 190 200
KAKKNKDKYV GVSSDSVGGF RYSERYDPEP KSKWDEEWDK NKSAFPFSDK
210 220 230 240 250
LGELSDKIGS TIDDTISKFR RKDREDSPER CSDSDEEKKA RRGRSPKGEF
260 270 280 290 300
KDEEETVTTK HIHITQATET TTTRHKRTAN PSKTIDLGAA AHYTGDKASP
310 320 330 340 350
DQNASTHTPQ SSLKTSVPSS KSSGDLVDLF DGTSQSTGGS ADLFGGFADF
360 370 380 390 400
GSAAASGNFP SQVTATSGNG DFGDWSAFNQ APSVPVAASG ELFGSASQPA
410 420 430 440 450
VELVSSSQPA LGPPPAASNS SDLFDLMGSS QATMTSSQSM NFSMMSTNTV
460 470 480 490 500
GLGLPMSRSQ PLQNVSTVLQ KPNPLYNQNT DMVQKSVSKT LPSTWSDPSV
510 520 530 540 550
NISLDNLLPG MQPSKPQQPS LNTMIQQQNM QQPMNMMTQS FGAVNLSSPS
560 570 580 590 600
NMLPVRPQTN PLMGGPMPMS MPNVMTGTMG MAPLGNSPMM NQSMMGMNMN
610 620 630 640
IGMSTTGMGL TGTMGMGMPN LAMTSGTMQP KQDAFANFAN FSK
Length:643
Mass (Da):70,522
Last modified:October 23, 2007 - v1
Checksum:iAD3C958C0DE96638
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC153233 mRNA Translation: AAI53234.1
RefSeqiNP_001098887.1, NM_001105417.1
UniGeneiBt.51195

Genome annotation databases

EnsembliENSBTAT00000021559; ENSBTAP00000021559; ENSBTAG00000016199
GeneIDi538540
KEGGibta:538540

Similar proteinsi

Entry informationi

Entry nameiEPN4_BOVIN
AccessioniPrimary (citable) accession number: A7Z035
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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