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Protein

Clathrin interactor 1

Gene

CLINT1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei67Phosphatidylinositol lipid headgroupBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processEndocytosis
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin interactor 1
Alternative name(s):
Epsin-4
Gene namesi
Name:CLINT1
Synonyms:EPN4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

  • clathrin-coated vesicle Source: UniProtKB-SubCell
  • Golgi-associated vesicle Source: BHF-UCL
  • membrane Source: UniProtKB-SubCell
  • nucleoplasm Source: Ensembl
  • perinuclear region of cytoplasm Source: BHF-UCL
  • trans-Golgi network Source: BHF-UCL

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003284931 – 643Clathrin interactor 1Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei163PhosphoserineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei210PhosphoserineBy similarity1
Modified residuei227PhosphoserineBy similarity1
Modified residuei245PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei308PhosphothreonineBy similarity1
Modified residuei312PhosphoserineBy similarity1
Modified residuei642PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA7Z035.
PeptideAtlasiA7Z035.
PRIDEiA7Z035.

Expressioni

Gene expression databases

BgeeiENSBTAG00000016199.

Interactioni

Subunit structurei

Binds clathrin heavy chain, GGA2, AP-2 and AP1G1. Interacts with VTI1B.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021559.

Structurei

3D structure databases

ProteinModelPortaliA7Z035.
SMRiA7Z035.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 149ENTHPROSITE-ProRule annotationAdd BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 54Interaction with VTI1BBy similarity3
Regioni94 – 96Interaction with VTI1BBy similarity3
Regioni142 – 153Interaction with VTI1BBy similarityAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi268 – 273Poly-Thr6
Compositional biasi524 – 628Met-richAdd BLAST105

Sequence similaritiesi

Belongs to the epsin family.Curated

Phylogenomic databases

eggNOGiKOG2056. Eukaryota.
ENOG410XSM0. LUCA.
GeneTreeiENSGT00880000138029.
HOGENOMiHOG000082415.
HOVERGENiHBG048921.
InParanoidiA7Z035.
OMAiNMQQPMN.
OrthoDBiEOG091G0FWU.
TreeFamiTF313361.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiView protein in InterPro
IPR030544. CLINT1.
IPR013809. ENTH.
IPR008942. ENTH_VHS.
PANTHERiPTHR12276:SF73. PTHR12276:SF73. 1 hit.
PfamiView protein in Pfam
PF01417. ENTH. 1 hit.
SMARTiView protein in SMART
SM00273. ENTH. 1 hit.
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiView protein in PROSITE
PS50942. ENTH. 1 hit.

Sequencei

Sequence statusi: Complete.

A7Z035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNMWKVREL VDKATNVVMN YSEIESKVRE ATNDDPWGPS GQLMGEIAKA
60 70 80 90 100
TFMYEQFPEL MNMLWSRMLK DNKKNWRRVY KSLLLLAYLI RNGSERVVTS
110 120 130 140 150
AREHIYDLRS LENYHFVDEH GKDQGINIRQ KVKELVEFAQ DDDRLREERK
160 170 180 190 200
KAKKNKDKYV GVSSDSVGGF RYSERYDPEP KSKWDEEWDK NKSAFPFSDK
210 220 230 240 250
LGELSDKIGS TIDDTISKFR RKDREDSPER CSDSDEEKKA RRGRSPKGEF
260 270 280 290 300
KDEEETVTTK HIHITQATET TTTRHKRTAN PSKTIDLGAA AHYTGDKASP
310 320 330 340 350
DQNASTHTPQ SSLKTSVPSS KSSGDLVDLF DGTSQSTGGS ADLFGGFADF
360 370 380 390 400
GSAAASGNFP SQVTATSGNG DFGDWSAFNQ APSVPVAASG ELFGSASQPA
410 420 430 440 450
VELVSSSQPA LGPPPAASNS SDLFDLMGSS QATMTSSQSM NFSMMSTNTV
460 470 480 490 500
GLGLPMSRSQ PLQNVSTVLQ KPNPLYNQNT DMVQKSVSKT LPSTWSDPSV
510 520 530 540 550
NISLDNLLPG MQPSKPQQPS LNTMIQQQNM QQPMNMMTQS FGAVNLSSPS
560 570 580 590 600
NMLPVRPQTN PLMGGPMPMS MPNVMTGTMG MAPLGNSPMM NQSMMGMNMN
610 620 630 640
IGMSTTGMGL TGTMGMGMPN LAMTSGTMQP KQDAFANFAN FSK
Length:643
Mass (Da):70,522
Last modified:October 23, 2007 - v1
Checksum:iAD3C958C0DE96638
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC153233 mRNA. Translation: AAI53234.1.
RefSeqiNP_001098887.1. NM_001105417.1.
UniGeneiBt.51195.

Genome annotation databases

EnsembliENSBTAT00000021559; ENSBTAP00000021559; ENSBTAG00000016199.
GeneIDi538540.
KEGGibta:538540.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiEPN4_BOVIN
AccessioniPrimary (citable) accession number: A7Z035
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 23, 2007
Last modified: June 7, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families