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Protein

Probable hydrolase PNKD

Gene

PNKD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi172Zinc 1By similarity1
Metal bindingi174Zinc 1By similarity1
Metal bindingi176Zinc 2By similarity1
Metal bindingi177Zinc 2By similarity1
Metal bindingi229Zinc 1By similarity1
Metal bindingi253Zinc 1By similarity1
Metal bindingi253Zinc 2By similarity1
Metal bindingi291Zinc 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable hydrolase PNKD (EC:3.-.-.-)
Gene namesi
Name:PNKD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:33080 PNKD

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003111241 – 385Probable hydrolase PNKDAdd BLAST385

Proteomic databases

PaxDbiA7YY46
PRIDEiA7YY46

Expressioni

Gene expression databases

BgeeiENSBTAG00000003936
ExpressionAtlasiA7YY46 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005141

Structurei

3D structure databases

ProteinModelPortaliA7YY46
SMRiA7YY46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni291 – 293Substrate bindingBy similarity3
Regioni376 – 379Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0813 Eukaryota
COG0491 LUCA
GeneTreeiENSGT00530000063033
HOGENOMiHOG000058041
HOVERGENiHBG001152
InParanoidiA7YY46
OMAiHTVGHMI
OrthoDBiEOG091G08UZ
TreeFamiTF105273

Family and domain databases

CDDicd07723 hydroxyacylglutathione_hydrola, 1 hit
Gene3Di3.60.15.10, 1 hit
HAMAPiMF_01374 Glyoxalase_2, 1 hit
InterProiView protein in InterPro
IPR035680 Clx_II_MBL
IPR032282 HAGH_C
IPR017782 Hydroxyacylglutathione_Hdrlase
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
PfamiView protein in Pfam
PF16123 HAGH_C, 1 hit
PF00753 Lactamase_B, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
TIGRFAMsiTIGR03413 GSH_gloB, 1 hit

Sequencei

Sequence statusi: Complete.

A7YY46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVVAATAL KGRGARNARV LRGILSGATA NKASQNRSRA LQSHSSPECK
60 70 80 90 100
EEPEPLSPEL EYIPRKRGKN PMKAVGLAWY SLYTRTRLGY LFYRQQLRRA
110 120 130 140 150
RNRYPKGHSR TQPRLFNGVK VLPIPVLSDN YSYLIIDTQA RLAVAVDPSD
160 170 180 190 200
PQAVQASIEK EGVNLVAILC THKHWDHSGG NRDLSRRHQD CRVYGSPQDS
210 220 230 240 250
IPYLTHPLCH QDVVSVGRLQ IRALATPGHT QGHLVYLLDG EPYEGPSCLF
260 270 280 290 300
SGDLLFLSGC GRTFEGTAET MLSSLDTVLG LGDDTLLWPG HEYAEENLGF
310 320 330 340 350
AGVVEPENLA RERKMQWVQR QRMERKSTCP STLGEERSYN PFLRTHCLVL
360 370 380
QEALGPSPGP TGDDGCSRAQ LLERLRQLKD LHKSK
Length:385
Mass (Da):42,885
Last modified:October 23, 2007 - v1
Checksum:iA906CF6C2265017A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151298 mRNA Translation: AAI51299.1
RefSeqiNP_001107642.1, NM_001114170.1
UniGeneiBt.11304

Genome annotation databases

EnsembliENSBTAT00000005141; ENSBTAP00000005141; ENSBTAG00000003936
GeneIDi616561
KEGGibta:616561

Similar proteinsi

Entry informationi

Entry nameiPNKD_BOVIN
AccessioniPrimary (citable) accession number: A7YY46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 23, 2007
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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