ID   RPP40_BOVIN             Reviewed;         303 AA.
AC   A7YWU3;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   08-NOV-2023, entry version 63.
DE   RecName: Full=Ribonuclease P protein subunit p40;
DE            Short=RNaseP protein p40;
GN   Name=RPP40;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that
CC       generates mature tRNA molecules by cleaving their 5'-ends. Also a
CC       component of the MRP ribonuclease complex, which cleaves pre-rRNA
CC       sequences. {ECO:0000250|UniProtKB:O75818}.
CC   -!- SUBUNIT: Component of nuclear RNase P and RNase MRP ribonucleoproteins.
CC       RNase P consists of a catalytic RNA moiety and about 10 protein
CC       subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and
CC       RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the
CC       'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the
CC       'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist'
CC       subcomplex. All subunits of the RNase P complex interact with the
CC       catalytic RNA. Several subunits of RNase P are also part of the RNase
CC       MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8
CC       protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly
CC       also POP4 and POP5. {ECO:0000250|UniProtKB:O75818}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI34789.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC134788; AAI34789.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001098872.1; NM_001105402.2.
DR   AlphaFoldDB; A7YWU3; -.
DR   SMR; A7YWU3; -.
DR   STRING; 9913.ENSBTAP00000004325; -.
DR   PaxDb; 9913-ENSBTAP00000004325; -.
DR   GeneID; 531274; -.
DR   KEGG; bta:531274; -.
DR   CTD; 10799; -.
DR   eggNOG; ENOG502QSAV; Eukaryota.
DR   InParanoid; A7YWU3; -.
DR   OrthoDB; 313919at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0030681; C:multimeric ribonuclease P complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000172; C:ribonuclease MRP complex; IBA:GO_Central.
DR   GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-EC.
DR   GO; GO:0033204; F:ribonuclease P RNA binding; ISS:UniProtKB.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0001682; P:tRNA 5'-leader removal; ISS:UniProtKB.
DR   InterPro; IPR013893; RNase_P_Rpp40.
DR   PANTHER; PTHR15396; RIBONUCLEASE P PROTEIN SUBUNIT P40; 1.
DR   PANTHER; PTHR15396:SF1; RIBONUCLEASE P PROTEIN SUBUNIT P40; 1.
DR   Pfam; PF08584; Ribonuc_P_40; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; rRNA processing; tRNA processing.
FT   CHAIN           1..303
FT                   /note="Ribonuclease P protein subunit p40"
FT                   /id="PRO_0000354075"
SQ   SEQUENCE   303 AA;  34096 MW;  F62D4C320821BD4B CRC64;
     MGFGPYYFVK GLPLYELITH EFINTFVKKG SCYALTYNTN IDEDNTVALL PNGKLILSLD
     KDTYEETGLQ GCPSQYSGRK TMRFIVSIDL MDLSSNLDSK KYKRVSWAFK EKKPLKFDFL
     LAWHQTGAEG STMMSYFSGY GIQEHQPKIA LSTTPDLRCP VLRSGLLGGE PEAACSAHEL
     FDWLGAVFSH ADLNNEPYNF VSTYCCPQPS SVVAQASLCS VTGFLLPERI CVLLEQLCRY
     FDEPKLAPWV TLSVQGFADS PVSWRESEHG FQKGGEHLYN FVIFNNRDYW LQMAVGADDD
     CPP
//