A7YWU3 (RPP40_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein subunit p40
Short name=RNaseP protein p40
EC=3.1.26.5

Gene names

Name:

RPP40

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40 By similarity.
Subcellular location	Nucleus › nucleolus Potential.
Sequence caution	The sequence AAI34789.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Ribonuclease P protein subunit p40		PRO_0000354075

Sequences

	Sequence		Length	Mass (Da)
	A7YWU3 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: F62D4C320821BD4B	FASTA	303	34,096
	10 20 30 40 50 60 MGFGPYYFVK GLPLYELITH EFINTFVKKG SCYALTYNTN IDEDNTVALL PNGKLILSLD 70 80 90 100 110 120 KDTYEETGLQ GCPSQYSGRK TMRFIVSIDL MDLSSNLDSK KYKRVSWAFK EKKPLKFDFL 130 140 150 160 170 180 LAWHQTGAEG STMMSYFSGY GIQEHQPKIA LSTTPDLRCP VLRSGLLGGE PEAACSAHEL 190 200 210 220 230 240 FDWLGAVFSH ADLNNEPYNF VSTYCCPQPS SVVAQASLCS VTGFLLPERI CVLLEQLCRY 250 260 270 280 290 300 FDEPKLAPWV TLSVQGFADS PVSWRESEHG FQKGGEHLYN FVIFNNRDYW LQMAVGADDD CPP

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal pons.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC134788 mRNA. Translation: AAI34789.1. Different initiation.
IPI	IPI00868621.
RefSeq	NP_001098872.1. NM_001105402.2.
UniGene	Bt.83862.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000004325.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	531274.
KEGG	bta:531274.
Organism-specific databases
CTD	10799.
Phylogenomic databases
eggNOG	NOG42164.
HOGENOM	HOG000006875.
HOVERGEN	HBG055018.
InParanoid	A7YWU3.
KO	K14530.
OrthoDB	EOG4DR9CW.
Family and domain databases
InterPro	IPR013893. RNase_P_Rpp40. [Graphical view]
Pfam	PF08584. Ribonuc_P_40. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20875426.

Entry information

Entry name

RPP40_BOVIN

Accession

Primary (citable) accession number: A7YWU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	November 25, 2008
Last modified:	April 3, 2013
This is version 30 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program