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Protein

Ribonuclease P protein subunit p40

Gene

RPP40

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p40 (EC:3.1.26.5)
Short name:
RNaseP protein p40
Gene namesi
Name:RPP40
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Ribonuclease P protein subunit p40PRO_0000354075Add
BLAST

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004325.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG42164.
HOGENOMiHOG000006875.
HOVERGENiHBG055018.
InParanoidiA7YWU3.
KOiK14530.

Family and domain databases

InterProiIPR013893. RNase_P_Rpp40.
[Graphical view]
PfamiPF08584. Ribonuc_P_40. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7YWU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFGPYYFVK GLPLYELITH EFINTFVKKG SCYALTYNTN IDEDNTVALL
60 70 80 90 100
PNGKLILSLD KDTYEETGLQ GCPSQYSGRK TMRFIVSIDL MDLSSNLDSK
110 120 130 140 150
KYKRVSWAFK EKKPLKFDFL LAWHQTGAEG STMMSYFSGY GIQEHQPKIA
160 170 180 190 200
LSTTPDLRCP VLRSGLLGGE PEAACSAHEL FDWLGAVFSH ADLNNEPYNF
210 220 230 240 250
VSTYCCPQPS SVVAQASLCS VTGFLLPERI CVLLEQLCRY FDEPKLAPWV
260 270 280 290 300
TLSVQGFADS PVSWRESEHG FQKGGEHLYN FVIFNNRDYW LQMAVGADDD

CPP
Length:303
Mass (Da):34,096
Last modified:November 25, 2008 - v2
Checksum:iF62D4C320821BD4B
GO

Sequence cautioni

The sequence AAI34789.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134788 mRNA. Translation: AAI34789.1. Different initiation.
RefSeqiNP_001098872.1. NM_001105402.2.
UniGeneiBt.83862.

Genome annotation databases

GeneIDi531274.
KEGGibta:531274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC134788 mRNA. Translation: AAI34789.1. Different initiation.
RefSeqiNP_001098872.1. NM_001105402.2.
UniGeneiBt.83862.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi531274.
KEGGibta:531274.

Organism-specific databases

CTDi10799.

Phylogenomic databases

eggNOGiNOG42164.
HOGENOMiHOG000006875.
HOVERGENiHBG055018.
InParanoidiA7YWU3.
KOiK14530.

Miscellaneous databases

NextBioi20875426.

Family and domain databases

InterProiIPR013893. RNase_P_Rpp40.
[Graphical view]
PfamiPF08584. Ribonuc_P_40. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons.

Entry informationi

Entry nameiRPP40_BOVIN
AccessioniPrimary (citable) accession number: A7YWU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: January 7, 2015
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.