Reviewed, UniProtKB/Swiss-Prot A7YWM1 (GGT6_BOVIN)

Names and origin

Protein names

Recommended name:
    Gamma-glutamyltransferase 6
    EC=2.3.2.2
Alternative name(s):
    Gamma-glutamyltranspeptidase 6
      Short name=GGT 6
Cleaved into the following 2 chains:
    1- Recommended name:
            Gamma-glutamyltransferase 6 heavy chain
    2- Recommended name:
            Gamma-glutamyltransferase 6 light chain

Gene names

Name:

GGT6

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cleaves glutathione conjugates By similarity.
Catalytic activity	(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.
Pathway	Sulfur metabolism; glutathione metabolism.
Subunit structure	Heterodimer composed of the light and heavy chains. The active site is located in the light chain By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the gamma-glutamyltransferase family.

Ontologies

Keywords
Biological process	Glutathione biosynthesis
Cellular component	Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Acyltransferase Transferase
PTM	Glycoprotein Zymogen
Gene Ontology (GO)
Biological process	glutathione biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW gamma-glutamyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ?		Gamma-glutamyltransferase 6 heavy chain		PRO_0000314952
	Chain	? – 490		Gamma-glutamyltransferase 6 light chain		PRO_0000314953
Regions
	Topological domain	1 – 52	52	Cytoplasmic Potential
	Transmembrane	53 – 73	21	Signal-anchor for type II membrane protein Potential
	Topological domain	74 – 490	417	Extracellular Potential
	Compositional bias	21 – 28	8	Poly-Glu
Amino acid modifications
	Glycosylation	160	1	N-linked (GlcNAc...) Potential
	Glycosylation	165	1	N-linked (GlcNAc...) Potential
	Glycosylation	374	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	A7YWM1-1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 52764AEA59A4D50A	FASTA	490	49,626
	10 20 30 40 50 60 MEPEAGPVLY QKLRVWEPSL ESEEEEEEIS EQLILDASGP HDSSGNKAGR LPGAWAQLVA 70 80 90 100 110 120 ALLLLAIGFS LAVRQLCSSG ASPGALGSGA PPASGHSHRP GVYHHGAIIS PAAECSRLGR 130 140 150 160 170 180 ELFVAGGNIV DAGVGAALCL AVVHPHTTGL GATYWGLFHN SSSGNSTALT SGPAQTLAPG 190 200 210 220 230 240 LGLPSALPAL HMLHTHFGRL PWPHLLVGPI SLAQKGFLVD TSLASALAAQ DTKGLCPLLC 250 260 270 280 290 300 HANGTPLGPG TQVTNTKLAA VLHKASLAPT PDLSGDALLS LLAEDLGLEG PSVGPRPTLE 310 320 330 340 350 360 PALQLPLPQG ILFTTPSPSA GPELLELLEA SLQSAGPSPA PCPALPQAAA APRSSVLATV 370 380 390 400 410 420 DSSGSVLLLT SSLNSSFGSG HLSPSTGVLL SNLVAESAAG AWACPLIFRD ISDDTEVDVL 430 440 450 460 470 480 GLVASGTPAA ARVMTHALLS HLARPQTPDQ QGPTESPRAC AQGTLLQVAA HTEHAHVSSV 490 PSGCCPFQGF

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal skin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC134652 mRNA. Translation: AAI34653.1.
IPI	IPI00868599.
RefSeq	NP_001098904.1.
UniGene	Bt.27489
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000035110; ENSBTAP00000034988; ENSBTAG00000007436; Bos taurus. [Genome view]
GeneID	613919.
KEGG	bta:613919.
Organism-specific databases
CTD	613919.
Enzyme and pathway databases
BRENDA	2.3.2.2. 251.
Family and domain databases
InterPro	IPR000101. GGT_peptidase. [Graphical view]
PANTHER	PTHR11686. GGT_peptidase. 1 hit.
Pfam	PF01019. G_glu_transpept. 1 hit. [Graphical view]
PRINTS	PR01210. GGTRANSPTASE.
PROSITE	PS00462. G_GLU_TRANSPEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GGT6_BOVIN

Accession

Primary (citable) accession number: A7YWM1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	October 13, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)