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Reviewed, UniProtKB/Swiss-Prot A7YWM1 (GGT6_BOVIN)

Last modified October 13, 2009. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Gamma-glutamyltransferase 6
    EC=2.3.2.2
Alternative name(s):
    Gamma-glutamyltranspeptidase 6
      Short name=GGT 6
Cleaved into the following 2 chains:
    1- Recommended name:
            Gamma-glutamyltransferase 6 heavy chain
    2- Recommended name:
            Gamma-glutamyltransferase 6 light chain
Gene names
Name: GGT6
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Cleaves glutathione conjugates By similarity.

Catalytic activity

(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.

Pathway

Sulfur metabolism; glutathione metabolism.

Subunit structure

Heterodimer composed of the light and heavy chains. The active site is located in the light chain By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the gamma-glutamyltransferase family.

Ontologies

Keywords
   Biological processGlutathione biosynthesis
   Cellular componentMembrane
   DomainSignal-anchor
Transmembrane
   Molecular functionAcyltransferase
Transferase
   PTMGlycoprotein
Zymogen
Gene Ontology (GO)
   Biological processglutathione biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

gamma-glutamyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ?Gamma-glutamyltransferase 6 heavy chainPRO_0000314952
Chain? – 490Gamma-glutamyltransferase 6 light chainPRO_0000314953

Regions

Topological domain1 – 5252Cytoplasmic Potential
Transmembrane53 – 7321Signal-anchor for type II membrane protein Potential
Topological domain74 – 490417Extracellular Potential
Compositional bias21 – 288Poly-Glu

Amino acid modifications

Glycosylation1601N-linked (GlcNAc...) Potential
Glycosylation1651N-linked (GlcNAc...) Potential
Glycosylation3741N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A7YWM1-1 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 52764AEA59A4D50A

FASTA49049,626
        10         20         30         40         50         60 
MEPEAGPVLY QKLRVWEPSL ESEEEEEEIS EQLILDASGP HDSSGNKAGR LPGAWAQLVA 

        70         80         90        100        110        120 
ALLLLAIGFS LAVRQLCSSG ASPGALGSGA PPASGHSHRP GVYHHGAIIS PAAECSRLGR 

       130        140        150        160        170        180 
ELFVAGGNIV DAGVGAALCL AVVHPHTTGL GATYWGLFHN SSSGNSTALT SGPAQTLAPG 

       190        200        210        220        230        240 
LGLPSALPAL HMLHTHFGRL PWPHLLVGPI SLAQKGFLVD TSLASALAAQ DTKGLCPLLC 

       250        260        270        280        290        300 
HANGTPLGPG TQVTNTKLAA VLHKASLAPT PDLSGDALLS LLAEDLGLEG PSVGPRPTLE 

       310        320        330        340        350        360 
PALQLPLPQG ILFTTPSPSA GPELLELLEA SLQSAGPSPA PCPALPQAAA APRSSVLATV 

       370        380        390        400        410        420 
DSSGSVLLLT SSLNSSFGSG HLSPSTGVLL SNLVAESAAG AWACPLIFRD ISDDTEVDVL 

       430        440        450        460        470        480 
GLVASGTPAA ARVMTHALLS HLARPQTPDQ QGPTESPRAC AQGTLLQVAA HTEHAHVSSV 

       490 
PSGCCPFQGF 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal skin.

Cross-references

Sequence databases

BC134652 mRNA. Translation: AAI34653.1.
IPIIPI00868599.
RefSeqNP_001098904.1.
UniGeneBt.27489

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSBTAT00000035110; ENSBTAP00000034988; ENSBTAG00000007436; Bos taurus. [Genome view]
GeneID613919.
KEGGbta:613919.

Organism-specific databases

CTD613919.

Enzyme and pathway databases

BRENDA2.3.2.2. 251.

Family and domain databases

InterProIPR000101. GGT_peptidase.
[Graphical view]
PANTHERPTHR11686. GGT_peptidase. 1 hit.
PfamPF01019. G_glu_transpept. 1 hit.
[Graphical view]
PRINTSPR01210. GGTRANSPTASE.
PROSITEPS00462. G_GLU_TRANSPEPTIDASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGGT6_BOVIN
AccessionPrimary (citable) accession number: A7YWM1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: October 13, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents