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A7YW98

- SYRC_BOVIN

UniProt

A7YW98 - SYRC_BOVIN

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Protein

Arginine--tRNA ligase, cytoplasmic

Gene

RARS

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (By similarity).By similarity

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).By similarity

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_209045. Cytosolic tRNA aminoacylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase, cytoplasmic (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRSBy similarity
Gene namesi
Name:RARSImported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660Arginine--tRNA ligase, cytoplasmicPRO_0000395433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiA7YW98.

Interactioni

Subunit structurei

Interacts (via N-terminus) with AIMP1 (via N-terminus); this stimulates its catalytic activity. Interacts (via N-terminus) with LARS2 (via C-terminus). Monomer; also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro (By similarity). Interacts with QARS (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019475.

Structurei

3D structure databases

ProteinModelPortaliA7YW98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7272Could be involved in the assembly of the multisynthetase complexBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi201 – 21212"HIGH" regionBy similarityAdd
BLAST

Domaini

The N-terminus (AA 1-72) has two regions predicted to be alpha-helical that might be involved in the multisynthetase complex assembly.By similarity

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG0018.
GeneTreeiENSGT00530000063407.
HOGENOMiHOG000247212.
HOVERGENiHBG029238.
InParanoidiA7YW98.
KOiK01887.
OMAiKCFDILG.
OrthoDBiEOG764725.
TreeFamiTF106111.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7YW98-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDALVAHCSA RLLQQEKEIK FLTAEVDRLK NYSCSEASAD LEKLREENLK
60 70 80 90 100
LKYRLNILRK SLQAERNKPT KTMININSCL EEVFGCAIKA AYPVLENPPL
110 120 130 140 150
IVTPSQQPKF GDYQCNSAMG ICQMLKTKEQ KVNPREIAEN IVKHLPDNEY
160 170 180 190 200
IEKVEIAGPG FINIHLRKGF VSQQLTNLLV NGVKIPSIGE NKKVIVDFSS
210 220 230 240 250
PNIAKEMHVG HLRSTIIGES MCRLFEFAGY NVLRLNHVGD WGTQFGMLIA
260 270 280 290 300
HLQDKFPDYL TVSPPIGDLQ AFYKESKKRF DTEEEFKKRA YQCVVLLQSK
310 320 330 340 350
NPDIIKAWKL ICDVSRQEFN KIYEALDISL IERGESFYQD RMHDIVKEFE
360 370 380 390 400
DRGFVQVDDG RKIVFVPGCS VPLTIVKSDG GYTYDTSDLA AIKQRLFEEK
410 420 430 440 450
ADMIIYVVDN GQSLHFQTVF GAAQMIGWYD PAVTRVSHAG FGVVLGEDKK
460 470 480 490 500
KFKTRSGETV RLIDLLEEGL KRSMDKLKEK ERDKVLTTEE LKAAQTSVAY
510 520 530 540 550
GCIKYADLSH NRLNDYIFSF DKMLDDRGNT AAYLLYAFTR IRSIARLANI
560 570 580 590 600
DEEMLRKAAH ETEIILDHEK EWKLGRCILR FPEVLQKILD DLLLHTLCDY
610 620 630 640 650
IYELATTFTE FYDSCYCVEK DRQSGEVLKV NMWRMLLCEA VAAVMAKGFD
660
ILGIKPVQRM
Length:660
Mass (Da):75,561
Last modified:October 23, 2007 - v1
Checksum:iEA5DCB46414C81C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC134468 mRNA. Translation: AAI34469.1.
RefSeqiNP_001098808.1. NM_001105338.2.
UniGeneiBt.22038.

Genome annotation databases

EnsembliENSBTAT00000019475; ENSBTAP00000019475; ENSBTAG00000014626.
GeneIDi506305.
KEGGibta:506305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC134468 mRNA. Translation: AAI34469.1 .
RefSeqi NP_001098808.1. NM_001105338.2.
UniGenei Bt.22038.

3D structure databases

ProteinModelPortali A7YW98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000019475.

Proteomic databases

PRIDEi A7YW98.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000019475 ; ENSBTAP00000019475 ; ENSBTAG00000014626 .
GeneIDi 506305.
KEGGi bta:506305.

Organism-specific databases

CTDi 5917.

Phylogenomic databases

eggNOGi COG0018.
GeneTreei ENSGT00530000063407.
HOGENOMi HOG000247212.
HOVERGENi HBG029238.
InParanoidi A7YW98.
KOi K01887.
OMAi KCFDILG.
OrthoDBi EOG764725.
TreeFami TF106111.

Enzyme and pathway databases

Reactomei REACT_209045. Cytosolic tRNA aminoacylation.

Miscellaneous databases

NextBioi 20867548.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: HerefordImported.
    Tissue: ThymusImported.

Entry informationi

Entry nameiSYRC_BOVIN
AccessioniPrimary (citable) accession number: A7YW98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3