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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic

Gene

accD

Organism
Ipomoea purpurea (Common morning glory) (Pharbitis purpurea)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi230ZincUniRule annotation1
Metal bindingi233ZincUniRule annotation1
Metal bindingi249ZincUniRule annotation1
Metal bindingi252ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri230 – 252C4-typeUniRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplasticUniRule annotation (EC:6.4.1.2UniRule annotation)
Short name:
ACCase subunit betaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit betaUniRule annotation
Gene namesi
Name:accDUniRule annotation
Encoded oniPlastid; Chloroplast
OrganismiIpomoea purpurea (Common morning glory) (Pharbitis purpurea)
Taxonomic identifieri4121 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

Subcellular locationi

  • Plastidchloroplast stroma UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003591451 – 509Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplasticAdd BLAST509

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and 2 subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).By similarity

Structurei

3D structure databases

ProteinModelPortaliA7Y3E9.
SMRiA7Y3E9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 509CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST284

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri230 – 252C4-typeUniRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A7Y3E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKWRIYSFQ KEFERRCGLN SSLGPIETTG EDPNRKDTVK NIQSWEDCDN
60 70 80 90 100
SSCSNVDHLF GVKDNENFIS DDTFVVFDIE NQIFEIDNDH SFLNEPFSSY
110 120 130 140 150
SDRNSSYLTN VFTSEDPYYN RYMYDAQYSW NNHINGCIDS YLQSQICIDT
160 170 180 190 200
TTVSGSDNDS YDIHGSVCDG ESHNSSEGES SSRRTHTKGV DLTIRESSNE
210 220 230 240 250
NERESSNENE RKSSNDLDRT KKYRDLWLQC ENCYGLNYKK FLKSKMNICE
260 270 280 290 300
QCGYHLKMSS SDRIELLIDP GTWDPMDEYM VSQDPIEFDS EGEQEQEQEQ
310 320 330 340 350
EQEEEETYKD RIDFYQTKTG LTEAVQTGIG QLNGIPVAIG VMDFHFLGGS
360 370 380 390 400
MGSVVGEKIT RLIEHATNNF LPLIIVCASG GARMQEGSLS LMQMAKISSA
410 420 430 440 450
LYEYQLNKRL FYVSILTSPT TGGVTASFGM LGDVIIVEPN AYVAFAGKRV
460 470 480 490 500
IEQTLNQTVP EGSQEAEYLF EKGLFDLIVP RHLLKSVLSE LFEFHALFPL

NQNSNQVEC
Length:509
Mass (Da):57,942
Last modified:October 23, 2007 - v1
Checksum:i827C1ABAE72F7175
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU118126 Genomic DNA. Translation: ABV02357.1.
RefSeqiYP_001468317.1. NC_009808.1.

Genome annotation databases

GeneIDi5601288.

Similar proteinsi

Entry informationi

Entry nameiACCD_IPOPU
AccessioniPrimary (citable) accession number: A7Y3E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: October 23, 2007
Last modified: May 10, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families