A7XZY7 (A7XZY7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Intersectin 1 short form variant 4 EMBL ABV03351.1

Gene names

Name:

ITSN1 EMBL ABV03351.1

Organism

Homo sapiens (Human) EMBL ABV03351.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1183 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 5 SH3 domains. RuleBase RU003338

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338
Gene Ontology (GO)
Biological_process	endocytosis Inferred from electronic annotation. Source: InterPro
Cellular_component	plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A7XZY7 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 8A762140D073A09C	FASTA	1,183	134,159
	10 20 30 40 50 60 MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ 70 80 90 100 110 120 IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP VMKQQPVAIS SAPAFAAVPP 130 140 150 160 170 180 LANGAPPVIQ PLPAFAHPAA TLPKSSSFSR SGPGSQLNTK LQKAQSFDVA SVPPVAEWAV 190 200 210 220 230 240 PQSSRLKYRQ LFNSHDKTMS GHLTGPQART ILMQSSLPQA QLASIWNLSD IDQDGKLTAE 250 260 270 280 290 300 EFILAMHLID VAMSGQPLPP VLPPEYIPPS FRRVRSGSGI SVISSTSVDQ RLPEEPVLED 310 320 330 340 350 360 EQQQLEKKLP VTFEDKKREN FERGNLELEK RRQALLEQQR KEQERLAQLE RAEQERKERE 370 380 390 400 410 420 RQEQERKRQL ELEKQLEKQR ELERQREEER RKEIERREAA KRELERQRQL EWERNRRQEL 430 440 450 460 470 480 LNQRNKEQED IVVLKAKKKT LEFELEALND KKHQLEGKLQ DIRCRLTTQR QEIESTNKSR 490 500 510 520 530 540 ELRIAEITHL QQQLQESQQM LGRLIPEKQI LNDQLKQVQQ NSLHRDSLVT LKRALEAKEL 550 560 570 580 590 600 ARQHLRDQLD EVEKETRSKL QEIDIFNNQL KELREIHNKQ QLQKQKSMEA ERLKQKEQER 610 620 630 640 650 660 KIIELEKQKE EAQRRAQERD KQWLEHVQQE DEHQRPRKLH EEEKLKREES VKKKDGEEKG 670 680 690 700 710 720 KQEAQDKLGR LFHQHQEPAK PAVQAPWSTA EKGPLTISAQ ENVKVVYYRA LYPFESRSHD 730 740 750 760 770 780 EITIQPGDIV MVKGEWVDES QTGEPGWLGG ELKGKTGWFP ANYAEKIPEN EVPAPVKPVT 790 800 810 820 830 840 DSTSAPAPKL ALRETPAPLA VTSSEPSTTP NNWADFSSTW PTSTNEKPET DNWDAWAAQP 850 860 870 880 890 900 SLTVPSAGQL RQRSAFTPAT ATGSSPSPVL GQGEKVEGLQ AQALYPWRAK KDNHLNFNKN 910 920 930 940 950 960 DVITVLEQQD MWWFGEVQGQ KGWFPKSYVK LISGPIRKST SMDSGSSESP ASLKRVASPA 970 980 990 1000 1010 1020 AKPVVSGEEF IAMYTYESSE QGDLTFQQGD VILVTKKDGD WWTGTVGDKA GVFPSNYVRL 1030 1040 1050 1060 1070 1080 KDSEGSGTAG KTGSLGKKPE IAQVIASYTA TGPEQLTLAP GQLILIRKKN PGGWWEGELQ 1090 1100 1110 1120 1130 1140 ARGKKRQIGW FPANYVKLLS PGTSKITPTE PPKSTALAAV CQVIGMYDYT AQNDDELAFN 1150 1160 1170 1180 KGQIINVLNK EDPDWWKGEV NGQVGLFPSN YVKLTTDMDP SQQ

References

[1]	"Structural diversity and differential expression of novel human intersectin 1 isoforms." Kropyvko S., Gerasymchuk D., Skrypkina I., Dergai M., Dergai O., Nikolaienko O., Rynditch A., Tsyba L. Mol. Biol. Rep. 37:2789-2796(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL ABV03351.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU107386 mRNA. Translation: ABV03351.1.
IPI	IPI00220592.
UniGene	Hs.160324.
3D structure databases
ProteinModelPortal	A7XZY7.
SMR	A7XZY7. Positions 876-934, 968-1023, 1033-1177.
ModBase	Search...
Proteomic databases
PRIDE	A7XZY7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc010gmi.3. human.
Phylogenomic databases
HOGENOM	HOG000010175.
HOVERGEN	HBG052159.
OrthoDB	EOG46Q6RS.
Gene expression databases
ArrayExpress	A7XZY7.
Bgee	A7XZY7.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR000261. EPS15_homology. IPR026813. ITSN1. IPR011511. SH3_2. IPR001452. SH3_domain. IPR013315. Spectrin_alpha_SH3. [Graphical view]
PANTHER	PTHR11216:SF28. PTHR11216:SF28. 1 hit.
Pfam	PF00018. SH3_1. 3 hits. PF07653. SH3_2. 2 hits. [Graphical view]
PRINTS	PR00452. SH3DOMAIN. PR01887. SPECTRNALPHA.
SMART	SM00054. EFh. 2 hits. SM00027. EH. 2 hits. SM00326. SH3. 5 hits. [Graphical view]
SUPFAM	SSF50044. SH3. 5 hits.
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. PS50031. EH. 2 hits. PS50002. SH3. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	35463564.

Entry information

Entry name

A7XZY7_HUMAN

Accession

Primary (citable) accession number: A7XZY7

Entry history

Integrated into UniProtKB/TrEMBL:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	May 29, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.