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A7XZY7 (A7XZY7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:ITSN1 EMBL ABV03351.1
OrganismHomo sapiens (Human) EMBL ABV03351.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1183 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Cellular_componentplasma membrane

Inferred from direct assay. Source: HPA

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A7XZY7 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 8A762140D073A09C

FASTA1,183134,159
        10         20         30         40         50         60 
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ 

        70         80         90        100        110        120 
IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP VMKQQPVAIS SAPAFAAVPP 

       130        140        150        160        170        180 
LANGAPPVIQ PLPAFAHPAA TLPKSSSFSR SGPGSQLNTK LQKAQSFDVA SVPPVAEWAV 

       190        200        210        220        230        240 
PQSSRLKYRQ LFNSHDKTMS GHLTGPQART ILMQSSLPQA QLASIWNLSD IDQDGKLTAE 

       250        260        270        280        290        300 
EFILAMHLID VAMSGQPLPP VLPPEYIPPS FRRVRSGSGI SVISSTSVDQ RLPEEPVLED 

       310        320        330        340        350        360 
EQQQLEKKLP VTFEDKKREN FERGNLELEK RRQALLEQQR KEQERLAQLE RAEQERKERE 

       370        380        390        400        410        420 
RQEQERKRQL ELEKQLEKQR ELERQREEER RKEIERREAA KRELERQRQL EWERNRRQEL 

       430        440        450        460        470        480 
LNQRNKEQED IVVLKAKKKT LEFELEALND KKHQLEGKLQ DIRCRLTTQR QEIESTNKSR 

       490        500        510        520        530        540 
ELRIAEITHL QQQLQESQQM LGRLIPEKQI LNDQLKQVQQ NSLHRDSLVT LKRALEAKEL 

       550        560        570        580        590        600 
ARQHLRDQLD EVEKETRSKL QEIDIFNNQL KELREIHNKQ QLQKQKSMEA ERLKQKEQER 

       610        620        630        640        650        660 
KIIELEKQKE EAQRRAQERD KQWLEHVQQE DEHQRPRKLH EEEKLKREES VKKKDGEEKG 

       670        680        690        700        710        720 
KQEAQDKLGR LFHQHQEPAK PAVQAPWSTA EKGPLTISAQ ENVKVVYYRA LYPFESRSHD 

       730        740        750        760        770        780 
EITIQPGDIV MVKGEWVDES QTGEPGWLGG ELKGKTGWFP ANYAEKIPEN EVPAPVKPVT 

       790        800        810        820        830        840 
DSTSAPAPKL ALRETPAPLA VTSSEPSTTP NNWADFSSTW PTSTNEKPET DNWDAWAAQP 

       850        860        870        880        890        900 
SLTVPSAGQL RQRSAFTPAT ATGSSPSPVL GQGEKVEGLQ AQALYPWRAK KDNHLNFNKN 

       910        920        930        940        950        960 
DVITVLEQQD MWWFGEVQGQ KGWFPKSYVK LISGPIRKST SMDSGSSESP ASLKRVASPA 

       970        980        990       1000       1010       1020 
AKPVVSGEEF IAMYTYESSE QGDLTFQQGD VILVTKKDGD WWTGTVGDKA GVFPSNYVRL 

      1030       1040       1050       1060       1070       1080 
KDSEGSGTAG KTGSLGKKPE IAQVIASYTA TGPEQLTLAP GQLILIRKKN PGGWWEGELQ 

      1090       1100       1110       1120       1130       1140 
ARGKKRQIGW FPANYVKLLS PGTSKITPTE PPKSTALAAV CQVIGMYDYT AQNDDELAFN 

      1150       1160       1170       1180 
KGQIINVLNK EDPDWWKGEV NGQVGLFPSN YVKLTTDMDP SQQ 

« Hide

References

[1]"Structural diversity and differential expression of novel human intersectin 1 isoforms."
Kropyvko S., Gerasymchuk D., Skrypkina I., Dergai M., Dergai O., Nikolaienko O., Rynditch A., Tsyba L.
Mol. Biol. Rep. 37:2789-2796(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain EMBL ABV03351.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EU107386 mRNA. Translation: ABV03351.1.
UniGeneHs.160324.

3D structure databases

ProteinModelPortalA7XZY7.
SMRA7XZY7. Positions 876-934, 968-1023, 1033-1177.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA7XZY7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

KEGGhsa:6453.
UCSCuc010gmi.3. human.

Phylogenomic databases

HOGENOMHOG000010175.
HOVERGENHBG052159.

Gene expression databases

ArrayExpressA7XZY7.
BgeeA7XZY7.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EPS15_homology.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PfamPF14604. SH3_9. 5 hits.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTSM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMSSF50044. SSF50044. 5 hits.
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50002. SH3. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi6453.
NextBio35463564.

Entry information

Entry nameA7XZY7_HUMAN
AccessionPrimary (citable) accession number: A7XZY7
Entry history
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.