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A7XZY7

- A7XZY7_HUMAN

UniProt

A7XZY7 - A7XZY7_HUMAN

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Protein
Submitted name:

Intersectin 1 short form variant 4

Gene

ITSN1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Intersectin 1 short form variant 4Imported
Gene namesi
Name:ITSN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiA7XZY7.

Expressioni

Gene expression databases

BgeeiA7XZY7.
ExpressionAtlasiA7XZY7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA7XZY7.
SMRiA7XZY7. Positions 876-934, 968-1023, 1033-1177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000010175.
HOVERGENiHBG052159.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EPS15_homology.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PfamiPF14604. SH3_9. 5 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 5 hits.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50002. SH3. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7XZY7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ
60 70 80 90 100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP
110 120 130 140 150
VMKQQPVAIS SAPAFAAVPP LANGAPPVIQ PLPAFAHPAA TLPKSSSFSR
160 170 180 190 200
SGPGSQLNTK LQKAQSFDVA SVPPVAEWAV PQSSRLKYRQ LFNSHDKTMS
210 220 230 240 250
GHLTGPQART ILMQSSLPQA QLASIWNLSD IDQDGKLTAE EFILAMHLID
260 270 280 290 300
VAMSGQPLPP VLPPEYIPPS FRRVRSGSGI SVISSTSVDQ RLPEEPVLED
310 320 330 340 350
EQQQLEKKLP VTFEDKKREN FERGNLELEK RRQALLEQQR KEQERLAQLE
360 370 380 390 400
RAEQERKERE RQEQERKRQL ELEKQLEKQR ELERQREEER RKEIERREAA
410 420 430 440 450
KRELERQRQL EWERNRRQEL LNQRNKEQED IVVLKAKKKT LEFELEALND
460 470 480 490 500
KKHQLEGKLQ DIRCRLTTQR QEIESTNKSR ELRIAEITHL QQQLQESQQM
510 520 530 540 550
LGRLIPEKQI LNDQLKQVQQ NSLHRDSLVT LKRALEAKEL ARQHLRDQLD
560 570 580 590 600
EVEKETRSKL QEIDIFNNQL KELREIHNKQ QLQKQKSMEA ERLKQKEQER
610 620 630 640 650
KIIELEKQKE EAQRRAQERD KQWLEHVQQE DEHQRPRKLH EEEKLKREES
660 670 680 690 700
VKKKDGEEKG KQEAQDKLGR LFHQHQEPAK PAVQAPWSTA EKGPLTISAQ
710 720 730 740 750
ENVKVVYYRA LYPFESRSHD EITIQPGDIV MVKGEWVDES QTGEPGWLGG
760 770 780 790 800
ELKGKTGWFP ANYAEKIPEN EVPAPVKPVT DSTSAPAPKL ALRETPAPLA
810 820 830 840 850
VTSSEPSTTP NNWADFSSTW PTSTNEKPET DNWDAWAAQP SLTVPSAGQL
860 870 880 890 900
RQRSAFTPAT ATGSSPSPVL GQGEKVEGLQ AQALYPWRAK KDNHLNFNKN
910 920 930 940 950
DVITVLEQQD MWWFGEVQGQ KGWFPKSYVK LISGPIRKST SMDSGSSESP
960 970 980 990 1000
ASLKRVASPA AKPVVSGEEF IAMYTYESSE QGDLTFQQGD VILVTKKDGD
1010 1020 1030 1040 1050
WWTGTVGDKA GVFPSNYVRL KDSEGSGTAG KTGSLGKKPE IAQVIASYTA
1060 1070 1080 1090 1100
TGPEQLTLAP GQLILIRKKN PGGWWEGELQ ARGKKRQIGW FPANYVKLLS
1110 1120 1130 1140 1150
PGTSKITPTE PPKSTALAAV CQVIGMYDYT AQNDDELAFN KGQIINVLNK
1160 1170 1180
EDPDWWKGEV NGQVGLFPSN YVKLTTDMDP SQQ
Length:1,183
Mass (Da):134,159
Last modified:October 23, 2007 - v1
Checksum:i8A762140D073A09C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU107386 mRNA. Translation: ABV03351.1.
UniGeneiHs.160324.

Genome annotation databases

UCSCiuc010gmi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU107386 mRNA. Translation: ABV03351.1 .
UniGenei Hs.160324.

3D structure databases

ProteinModelPortali A7XZY7.
SMRi A7XZY7. Positions 876-934, 968-1023, 1033-1177.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A7XZY7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc010gmi.3. human.

Phylogenomic databases

HOGENOMi HOG000010175.
HOVERGENi HBG052159.

Miscellaneous databases

NextBioi 35463564.

Gene expression databases

Bgeei A7XZY7.
ExpressionAtlasi A7XZY7. baseline and differential.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EPS15_homology.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view ]
Pfami PF14604. SH3_9. 5 hits.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTi SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00326. SH3. 5 hits.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 5 hits.
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50002. SH3. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structural diversity and differential expression of novel human intersectin 1 isoforms."
    Kropyvko S., Gerasymchuk D., Skrypkina I., Dergai M., Dergai O., Nikolaienko O., Rynditch A., Tsyba L.
    Mol. Biol. Rep. 37:2789-2796(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiA7XZY7_HUMAN
AccessioniPrimary (citable) accession number: A7XZY7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.