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Protein

Sine oculis-binding protein homolog

Gene

Sobp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in development of the cochlea.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri142 – 180FCS-type 1Sequence analysisAdd BLAST39
Zinc fingeri216 – 256FCS-type 2Sequence analysisAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sine oculis-binding protein homolog
Alternative name(s):
Jackson circler protein 1
Gene namesi
Name:SobpBy similarity
Synonyms:Jxc1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1560479. Sobp.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003122341 – 864Sine oculis-binding protein homologAdd BLAST864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei627PhosphoserineBy similarity1
Cross-linki672Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei694PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiA7XYI6.

PTM databases

iPTMnetiA7XYI6.
PhosphoSitePlusiA7XYI6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000316.
GenevisibleiA7XYI6. RN.

Interactioni

Subunit structurei

Interacts (via SIM domains) with SUMO1 and SUMO2.By similarity

GO - Molecular functioni

Structurei

3D structure databases

SMRiA7XYI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi618 – 622SUMO interaction motif 1 (SIM); mediates the binding to polysumoylated substratesBy similarity5
Motifi648 – 652SUMO interaction motif 2 (SIM); mediates the binding to polysumoylated substratesBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi346 – 552Pro-richSequence analysisAdd BLAST207
Compositional biasi695 – 754Pro-richSequence analysisAdd BLAST60

Sequence similaritiesi

Belongs to the SOBP family.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri142 – 180FCS-type 1Sequence analysisAdd BLAST39
Zinc fingeri216 – 256FCS-type 2Sequence analysisAdd BLAST41

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEAE. Eukaryota.
ENOG4111QQS. LUCA.
GeneTreeiENSGT00730000111043.
HOVERGENiHBG062766.
InParanoidiA7XYI6.
OMAiTCGGCRD.
OrthoDBiEOG091G040K.
PhylomeDBiA7XYI6.

Family and domain databases

InterProiView protein in InterPro
IPR026092. RAI2/SOBP.
PANTHERiPTHR23186. PTHR23186. 1 hit.
PfamiView protein in Pfam
PF15279. SOBP. 1 hit.

Sequencei

Sequence statusi: Complete.

A7XYI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEMEKEGRP PENKRSRKPA HPVKREINEE MKNFAENTMN ELLGWYGYDK
60 70 80 90 100
VELKDGEDIE FRSYTTDGES RQHISVLKEN SLPKPKLPED SVISSYNIST
110 120 130 140 150
GYSGLATGNG LSDSPAGSKD HGNVPIIVPL IPPPFIKPPA EDEVSNVQIM
160 170 180 190 200
CAWCQKVGIK RYSLSMGSEV KSFCSEKCFA ACRRAYFKRN KARDEDGHAE
210 220 230 240 250
SFPQQHYAKE TPRLAFKNNC ELLVCDWCKH IRHTKEYLDF GDGERRLQFC
260 270 280 290 300
SAKCLNQYKM DIFYKETQAN LPAGLCGTLH PHMESKAEGT GVQLLTPDSW
310 320 330 340 350
NIPLTDARRK APSPVAAAGQ SQGPGPSSST TVSPSDTANC SVTKIPTPVP
360 370 380 390 400
KSLPISETPS IPPVSVQPPA SIGPPLGVPP RSPPMVMTNR GPVPLPIFME
410 420 430 440 450
QQIIQQIRPP FIRGPPHHAS NPNSPLSNPM LPGIGPPPGG PRNLGPTSSP
460 470 480 490 500
MHRPMLSPHI HPPSTPTMPG NPPGLLPPPP PGAPLPSLPF PPVSMMPNGP
510 520 530 540 550
MPVPQMMNFG LPSLAPLVPP PTLLVPYPVI VPLPVPIPIP IPIPHVNDSK
560 570 580 590 600
PPNGFSSNGE SFVPSAPGDS SAAGGKAGGR SLSPRDSKQG SSKSADSPPG
610 620 630 640 650
SSGQALSLAP SERGRGEVVD LTRRAASPAG AGGQPGFAGV LHGPQDGVID
660 670 680 690 700
LTVGHRARLH NVIHRALHAH VKAEREPGAA ERRTCGGCRD GHCSPPAAGD
710 720 730 740 750
PGPGAPAGPE AAAACNVIVN GTRSAPAEAK GAEPPPEQPP PPAPPKKLLS
760 770 780 790 800
PEEPAVNELE SVKENNCASN CHLDGEVTKK LMGEEALAGG DKSDPNLNNP
810 820 830 840 850
ADEDHAYALR MLPKTGCVIQ PVPKPAEKAA MTPCVISSPM LSAGPEDLEP
860
PLKRRCLRIR NQNK
Length:864
Mass (Da):91,771
Last modified:October 23, 2007 - v1
Checksum:iC96860E8B24E40EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ503410 mRNA. Translation: ABF56058.1.
RefSeqiNP_001098110.1. NM_001104640.1.
XP_006256636.1. XM_006256574.3.
UniGeneiRn.208930.

Genome annotation databases

EnsembliENSRNOT00000000348; ENSRNOP00000000348; ENSRNOG00000000316.
GeneIDi309860.
KEGGirno:309860.
UCSCiRGD:1560479. rat.

Similar proteinsi

Entry informationi

Entry nameiSOBP_RAT
AccessioniPrimary (citable) accession number: A7XYI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 23, 2007
Last modified: November 22, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families