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Protein

Sine oculis-binding protein homolog

Gene

Sobp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in development of the cochlea.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri142 – 18039FCS-type 1Sequence analysisAdd
BLAST
Zinc fingeri216 – 25641FCS-type 2Sequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sine oculis-binding protein homolog
Alternative name(s):
Jackson circler protein 1
Gene namesi
Name:SobpBy similarity
Synonyms:Jxc1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1560479. Sobp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Sine oculis-binding protein homologPRO_0000312234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei627 – 6271PhosphoserineBy similarity
Modified residuei694 – 6941PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA7XYI6.

PTM databases

PhosphoSiteiA7XYI6.

Expressioni

Gene expression databases

GenevisibleiA7XYI6. RN.

Interactioni

Subunit structurei

Interacts (via SIM domains) with SUMO1 and SUMO2.By similarity

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi618 – 6225SUMO interaction motif 1 (SIM); mediates the binding to polysumoylated substratesBy similarity
Motifi648 – 6525SUMO interaction motif 2 (SIM); mediates the binding to polysumoylated substratesBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi346 – 552207Pro-richSequence analysisAdd
BLAST
Compositional biasi695 – 75460Pro-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SOBP family.Sequence analysis
Contains 2 FCS-type zinc fingers.Sequence analysis

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri142 – 18039FCS-type 1Sequence analysisAdd
BLAST
Zinc fingeri216 – 25641FCS-type 2Sequence analysisAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEAE. Eukaryota.
ENOG4111QQS. LUCA.
GeneTreeiENSGT00730000111043.
HOVERGENiHBG062766.
InParanoidiA7XYI6.
OMAiEHGRSEV.
OrthoDBiEOG7F7W8D.
PhylomeDBiA7XYI6.

Family and domain databases

InterProiIPR026092. RAI2/SOBP.
[Graphical view]
PANTHERiPTHR23186. PTHR23186. 2 hits.
PfamiPF15279. SOBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7XYI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEMEKEGRP PENKRSRKPA HPVKREINEE MKNFAENTMN ELLGWYGYDK
60 70 80 90 100
VELKDGEDIE FRSYTTDGES RQHISVLKEN SLPKPKLPED SVISSYNIST
110 120 130 140 150
GYSGLATGNG LSDSPAGSKD HGNVPIIVPL IPPPFIKPPA EDEVSNVQIM
160 170 180 190 200
CAWCQKVGIK RYSLSMGSEV KSFCSEKCFA ACRRAYFKRN KARDEDGHAE
210 220 230 240 250
SFPQQHYAKE TPRLAFKNNC ELLVCDWCKH IRHTKEYLDF GDGERRLQFC
260 270 280 290 300
SAKCLNQYKM DIFYKETQAN LPAGLCGTLH PHMESKAEGT GVQLLTPDSW
310 320 330 340 350
NIPLTDARRK APSPVAAAGQ SQGPGPSSST TVSPSDTANC SVTKIPTPVP
360 370 380 390 400
KSLPISETPS IPPVSVQPPA SIGPPLGVPP RSPPMVMTNR GPVPLPIFME
410 420 430 440 450
QQIIQQIRPP FIRGPPHHAS NPNSPLSNPM LPGIGPPPGG PRNLGPTSSP
460 470 480 490 500
MHRPMLSPHI HPPSTPTMPG NPPGLLPPPP PGAPLPSLPF PPVSMMPNGP
510 520 530 540 550
MPVPQMMNFG LPSLAPLVPP PTLLVPYPVI VPLPVPIPIP IPIPHVNDSK
560 570 580 590 600
PPNGFSSNGE SFVPSAPGDS SAAGGKAGGR SLSPRDSKQG SSKSADSPPG
610 620 630 640 650
SSGQALSLAP SERGRGEVVD LTRRAASPAG AGGQPGFAGV LHGPQDGVID
660 670 680 690 700
LTVGHRARLH NVIHRALHAH VKAEREPGAA ERRTCGGCRD GHCSPPAAGD
710 720 730 740 750
PGPGAPAGPE AAAACNVIVN GTRSAPAEAK GAEPPPEQPP PPAPPKKLLS
760 770 780 790 800
PEEPAVNELE SVKENNCASN CHLDGEVTKK LMGEEALAGG DKSDPNLNNP
810 820 830 840 850
ADEDHAYALR MLPKTGCVIQ PVPKPAEKAA MTPCVISSPM LSAGPEDLEP
860
PLKRRCLRIR NQNK
Length:864
Mass (Da):91,771
Last modified:October 23, 2007 - v1
Checksum:iC96860E8B24E40EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ503410 mRNA. Translation: ABF56058.1.
RefSeqiNP_001098110.1. NM_001104640.1.
XP_006256636.1. XM_006256574.2.
UniGeneiRn.208930.

Genome annotation databases

EnsembliENSRNOT00000000348; ENSRNOP00000000348; ENSRNOG00000000316.
GeneIDi309860.
KEGGirno:309860.
UCSCiRGD:1560479. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ503410 mRNA. Translation: ABF56058.1.
RefSeqiNP_001098110.1. NM_001104640.1.
XP_006256636.1. XM_006256574.2.
UniGeneiRn.208930.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA7XYI6.

Proteomic databases

PaxDbiA7XYI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000348; ENSRNOP00000000348; ENSRNOG00000000316.
GeneIDi309860.
KEGGirno:309860.
UCSCiRGD:1560479. rat.

Organism-specific databases

CTDi55084.
RGDi1560479. Sobp.

Phylogenomic databases

eggNOGiENOG410IEAE. Eukaryota.
ENOG4111QQS. LUCA.
GeneTreeiENSGT00730000111043.
HOVERGENiHBG062766.
InParanoidiA7XYI6.
OMAiEHGRSEV.
OrthoDBiEOG7F7W8D.
PhylomeDBiA7XYI6.

Miscellaneous databases

NextBioi661414.
PROiA7XYI6.

Gene expression databases

GenevisibleiA7XYI6. RN.

Family and domain databases

InterProiIPR026092. RAI2/SOBP.
[Graphical view]
PANTHERiPTHR23186. PTHR23186. 2 hits.
PfamiPF15279. SOBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mutations in Jxc1 are associated with deafness, vestibular deficits and cochlea malformation in the Jackson circler (jc) mutant mouse."
    Noben-Trauth K.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiSOBP_RAT
AccessioniPrimary (citable) accession number: A7XYI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 23, 2007
Last modified: December 9, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.