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Protein
Submitted name:

Ionotropic glutamate receptor subunit NR2B

Gene

NR2B

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Ionotropic glutamate receptor subunit NR2BImported
Gene namesi
Name:NR2BImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei555 – 577HelicalSequence analysisAdd BLAST23
Transmembranei598 – 615HelicalSequence analysisAdd BLAST18
Transmembranei627 – 652HelicalSequence analysisAdd BLAST26
Transmembranei818 – 841HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500271539925 – 1448Sequence analysisAdd BLAST1424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi81 ↔ 316Combined sources
GlycosylationiCAR_5005389422336N-linked (GlcNAc...)Combined sources1
Disulfide bondi426 ↔ 453Combined sources
Disulfide bondi433 ↔ 454Combined sources
Disulfide bondi743 ↔ 798Combined sources

Interactioni

Protein-protein interaction databases

DIPiDIP-61037N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4TLLX-ray3.59B/D20-839[»]
4TLMX-ray3.77B/D20-839[»]
5IOUelectron microscopy7.00B/D1-839[»]
5IOVelectron microscopy7.50B/D1-839[»]
5IPQelectron microscopy13.50B/D1-839[»]
5IPRelectron microscopy14.10B/D1-839[»]
5IPSelectron microscopy13.50B/D1-839[»]
5IPTelectron microscopy14.10B/D1-839[»]
5IPUelectron microscopy15.40B/D1-839[»]
5IPVelectron microscopy9.25B/D1-839[»]
ProteinModelPortaliA7XY94.
SMRiA7XY94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini428 – 796PBPeInterPro annotationAdd BLAST369
Domaini439 – 500Lig_chan-Glu_bdInterPro annotationAdd BLAST62

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG052635.
KOiK05210.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR018884. NMDAR2_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
PF10565. NMDAR2_C. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

A7XY94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPTEACCYL KISLIILFYM GCYAQKHPNM DIAVILVGTT EEVAIKDVHE
60 70 80 90 100
KDDFHHLPVT PRVALVTMNE SDPKSIITRI CDLMSDKKVQ GVVFGDDTDQ
110 120 130 140 150
EAIAQILDFI SVQTLTPILG IHGGSSMIMA DKEEASMFFQ FGPSIEQQAS
160 170 180 190 200
VMLNIMEEYD WYIFSIVTTY FPGYQDFENK VRSTIENSFV GWELEEVIHL
210 220 230 240 250
DMSLDDIDSK IQNQLKKLQS PVILLYCTKE EATYIFEVAH SVGLTGYGFT
260 270 280 290 300
WIVPSLVAGD TDTVPDEFPT GLISVSYDEW DYDLPARVRD GIAIITTAAS
310 320 330 340 350
TMLSEHNSIP QSKSSCNNIQ ESRVYEAHML KRYLINVTFE GRNLSFSEDG
360 370 380 390 400
YQMHPKLVII LLNQERKWER VGKYKDRSLK MKYYVWPVFD LYPNSEEHKD
410 420 430 440 450
EHLSIVTLEE APFVIVEDVD PLSGTCMRNT VPCRKQIRPE NRTEEGGNYI
460 470 480 490 500
KRCCKGFCID ILKKIAKTVK FTYDLYLVTN GKHGKKINGT WNGMIGEVVT
510 520 530 540 550
KRAYMAVGSL TINEERSEVV DFSVPFIETG ISVMVSRSNG TVSPSAFLEP
560 570 580 590 600
FSADVWVMMF VMLLIVSAVA VFVFEYFSPV GYNRCLADGR EPGGPSFTIG
610 620 630 640 650
KAIWLLWGLV FNNSVPVQNP KGTTSKIMVS VWAFFAVIFL ASYTANLAAF
660 670 680 690 700
MIQEEYVDQV SGLSDKKFQR PNDFSPAFRF GTVPNGSTER NIRNNYLEMH
710 720 730 740 750
SYMVKFNQRS VQDALLSLKS GKLDAFIYDA AVLNYMAGRD EGCKLVTIGS
760 770 780 790 800
GKVFATTGYG IAIQKDSGWK RQVDLAILQL FGDGEMEELE ALWLTGICHN
810 820 830 840 850
EKNEVMSSQL DIDNMAGVFY MLAAAMALSL ITFIMEHLFF WQLRHCFMGV
860 870 880 890 900
CSGKPGMVFS ISRGIYSCIH GVAIEDRQSA LDSPSATMNN THSNILRLLR
910 920 930 940 950
TAKNMANLSG VNGSPQSALD FIRRESSVYD ISEHRRSFTH SDCKSFQPEE
960 970 980 990 1000
NLFSDYISEV ERTFGNLQLK DSNVYQDHFH HHRPHSIGSN SSIDGLYDCD
1010 1020 1030 1040 1050
NAPFTTQPRS LSKKPLDIGL PSKHPSPQIG DLYGKFSFKS DHYGAPDDLI
1060 1070 1080 1090 1100
RSDVSDISTH TVTYGNIEGN AKRRKQYKDS LKKRPASAKS RREFDEIELA
1110 1120 1130 1140 1150
YRRRQRSPDH KRYFRDKEGL RDFYLDQFRT KENNPHWEHV DLTHIYAERA
1160 1170 1180 1190 1200
DDFKHDTSCS NRQHQKHVGE FVQTDRKHGS GGNAWEKNMS NIEWEDRASS
1210 1220 1230 1240 1250
NFCRNCPSKM HNYTGQNTNR PACIRCEVCK KAGNLYDISE DNSLQDLEAR
1260 1270 1280 1290 1300
PIQAPNSKYP QSPNGKAQKR NRSKLHRQHS YDTFVDLQKE DVTLAPRSVS
1310 1320 1330 1340 1350
LKDKERFLDG SPYAHMFEMP NETSFTSKSH GPTHNPGGYM LSRSLYPDRV
1360 1370 1380 1390 1400
TQNPFIPTFG DDQCLLHGSK PYYFRQPAIG GLKGRADFRG AGKSLSAQHS
1410 1420 1430 1440
GPSGHFQKDI CIGNQPNACV SNNKNPRSFN NSTNGHVYEK LSSIESDV
Length:1,448
Mass (Da):163,913
Last modified:October 23, 2007 - v1
Checksum:iEBF9301FEE749D5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU104357 mRNA. Translation: ABU84989.1.
RefSeqiNP_001104191.1. NM_001110721.1.
UniGeneiXl.83851.

Genome annotation databases

GeneIDi100126610.
KEGGixla:100126610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU104357 mRNA. Translation: ABU84989.1.
RefSeqiNP_001104191.1. NM_001110721.1.
UniGeneiXl.83851.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4TLLX-ray3.59B/D20-839[»]
4TLMX-ray3.77B/D20-839[»]
5IOUelectron microscopy7.00B/D1-839[»]
5IOVelectron microscopy7.50B/D1-839[»]
5IPQelectron microscopy13.50B/D1-839[»]
5IPRelectron microscopy14.10B/D1-839[»]
5IPSelectron microscopy13.50B/D1-839[»]
5IPTelectron microscopy14.10B/D1-839[»]
5IPUelectron microscopy15.40B/D1-839[»]
5IPVelectron microscopy9.25B/D1-839[»]
ProteinModelPortaliA7XY94.
SMRiA7XY94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61037N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100126610.
KEGGixla:100126610.

Organism-specific databases

CTDi100126610.

Phylogenomic databases

HOVERGENiHBG052635.
KOiK05210.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR018884. NMDAR2_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
PF10565. NMDAR2_C. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA7XY94_XENLA
AccessioniPrimary (citable) accession number: A7XY94
Entry historyi
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 30, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.