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A7XWN5

- A7XWN5_SV40

UniProt

A7XWN5 - A7XWN5_SV40

Protein
Submitted name:

Large T antigen

Gene
N/A
Organism
Simian virus 40 (SV40)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA replication origin binding Source: InterPro
    3. hydrolase activity Source: UniProtKB-KW

    GO - Biological processi

    1. DNA replication Source: InterPro

    Keywords - Molecular functioni

    HydrolaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Large T antigenImported
    OrganismiSimian virus 40 (SV40)Imported
    Taxonomic identifieri10633 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePolyomaviridaePolyomavirus
    Virus hostiMacaca (macaques) [TaxID: 9539]

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4B8OX-ray2.08B/C125-132[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains SF3 helicase domain.SAAS annotation
    Contains SFhelicase domain.SAAS annotation

    Family and domain databases

    Gene3Di1.10.10.510. 1 hit.
    1.10.287.110. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR001623. DnaJ_domain.
    IPR014015. Helicase_SF3_DNA-vir.
    IPR016392. Lg_T_Ag_polyomavir.
    IPR010932. Lg_T_Ag_Polyomavir_C.
    IPR027417. P-loop_NTPase.
    IPR003133. T_Ag_DNA-bd.
    IPR017910. Znf_lg_T-Ag_D1-typ.
    [Graphical view]
    PfamiPF00226. DnaJ. 1 hit.
    PF06431. Polyoma_lg_T_C. 1 hit.
    PF02217. T_Ag_DNA_bind. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003368. Large_T_antigen_polyomaV. 1 hit.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50076. DNAJ_2. 1 hit.
    PS51206. SF3_HELICASE_1. 1 hit.
    PS51287. T_AG_OBD. 1 hit.
    PS51341. ZF_LTAG_D1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7XWN5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKVLNREES LQLMDLLGLE RSAWGNIPLM RKAYLKKCKE FHPDKGGDEE    50
    KMKKMNTLYK KMEDGVKYAH QPDFGGFWDA TEIPTYGTDE WEQWWNAFNE 100
    ENLFCSEEMP SSDDEATADS QHSTPPKKKR KVEDPKDFPS ELLSFLSHAV 150
    FSNRTLACFA IYTTKEKAAL LYKKIMEKYS VTFISRHNSY NHNILFFLTP 200
    HRHRVSAINN YAQKLCTFSF LICKGVNKEY LMYSALTRDP FSVIEESLPG 250
    GLKEHDFNPE EAEETKQVSW KLVTEYAMET KCDDVLLLLG MYLEFQYSFE 300
    MCLKCIKKEQ PSHYKYHEKH YANAAIFADS KNQKTICQQA VDTVLAKKRV 350
    DSLQLTREQM LTNRFNDLLD RMDIMFGSTG SADIEEWMAG VAWLHCLLPK 400
    MDSVVYDFLK CMVYNIPKKR YWLFKGPIDS GKTTLAAALL ELCGGKALNV 450
    NLPLDRLNFE LGVAIDQFLV VFEDVKGTGG ESRDLPSGQG INNLDNLRDY 500
    LDGSVKVNLE KKHLNKRTQI FPPGIVTMNE YSVPKTLQAR FVKQIDFRPK 550
    DYLKHCLERS EFLLEKRIIQ SGIALLLMLI WYRPVAEFAQ SIQSRIVEWK 600
    ERLDKEFSLS VYQKMKFNVA MGIGVLDWLR NSDDDDDDDS QENADKNEDG 650
    GEKNMEDSGH ETGIDSQSQG SFQAPQPSQS SQSVHDHNQP YHICRGFTCF 700
    KKPPTPPPEP ET 712
    Length:712
    Mass (Da):82,037
    Last modified:October 23, 2007 - v1
    Checksum:i765224F4005D5B55
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF579664 Genomic DNA. Translation: ABU86079.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF579664 Genomic DNA. Translation: ABU86079.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4B8O X-ray 2.08 B/C 125-132 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.10.510. 1 hit.
    1.10.287.110. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR001623. DnaJ_domain.
    IPR014015. Helicase_SF3_DNA-vir.
    IPR016392. Lg_T_Ag_polyomavir.
    IPR010932. Lg_T_Ag_Polyomavir_C.
    IPR027417. P-loop_NTPase.
    IPR003133. T_Ag_DNA-bd.
    IPR017910. Znf_lg_T-Ag_D1-typ.
    [Graphical view ]
    Pfami PF00226. DnaJ. 1 hit.
    PF06431. Polyoma_lg_T_C. 1 hit.
    PF02217. T_Ag_DNA_bind. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003368. Large_T_antigen_polyomaV. 1 hit.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50076. DNAJ_2. 1 hit.
    PS51206. SF3_HELICASE_1. 1 hit.
    PS51287. T_AG_OBD. 1 hit.
    PS51341. ZF_LTAG_D1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Recovery of strains of the polyomavirus SV40 from rhesus monkey kidney cells dating from the 1950s to the early 1960s."
      Peden K., Sheng L., Omeir R., Yacobucci M., Klutch M., Laassri M., Chumakov K., Pal A., Murata H., Lewis A.M.Jr.
      Virology 370:63-76(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SV40Imported.
    2. "Crystal structure of rice importin-? and structural basis of its interaction with plant-specific nuclear localization signals."
      Chang C.W., Counago R.L., Williams S.J., Boden M., Kobe B.
      Plant Cell 24:5074-5088(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF 125-132.

    Entry informationi

    Entry nameiA7XWN5_SV40
    AccessioniPrimary (citable) accession number: A7XWN5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3