A7XWN5 (A7XWN5_SV40) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Large T antigen EMBL ABU86079.1
Organism	Simian virus 40 (SV40) EMBL ABU86079.1
Taxonomic identifier	10633 [NCBI]
Taxonomic lineage	Viruses › dsDNA viruses, no RNA stage › Polyomaviridae › Polyomavirus
Virus host	Macaca (macaques) [TaxID: 9539]

Protein attributes

Sequence length	712 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 SF3 helicase domain. SAAS SAAS014015

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS014015 Nucleotide-binding
Molecular function	Hydrolase SAAS SAAS014015
Technical term	3D-structure PDB 4B8O
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A7XWN5 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 765224F4005D5B55	FASTA	712	82,037
	10 20 30 40 50 60 MDKVLNREES LQLMDLLGLE RSAWGNIPLM RKAYLKKCKE FHPDKGGDEE KMKKMNTLYK 70 80 90 100 110 120 KMEDGVKYAH QPDFGGFWDA TEIPTYGTDE WEQWWNAFNE ENLFCSEEMP SSDDEATADS 130 140 150 160 170 180 QHSTPPKKKR KVEDPKDFPS ELLSFLSHAV FSNRTLACFA IYTTKEKAAL LYKKIMEKYS 190 200 210 220 230 240 VTFISRHNSY NHNILFFLTP HRHRVSAINN YAQKLCTFSF LICKGVNKEY LMYSALTRDP 250 260 270 280 290 300 FSVIEESLPG GLKEHDFNPE EAEETKQVSW KLVTEYAMET KCDDVLLLLG MYLEFQYSFE 310 320 330 340 350 360 MCLKCIKKEQ PSHYKYHEKH YANAAIFADS KNQKTICQQA VDTVLAKKRV DSLQLTREQM 370 380 390 400 410 420 LTNRFNDLLD RMDIMFGSTG SADIEEWMAG VAWLHCLLPK MDSVVYDFLK CMVYNIPKKR 430 440 450 460 470 480 YWLFKGPIDS GKTTLAAALL ELCGGKALNV NLPLDRLNFE LGVAIDQFLV VFEDVKGTGG 490 500 510 520 530 540 ESRDLPSGQG INNLDNLRDY LDGSVKVNLE KKHLNKRTQI FPPGIVTMNE YSVPKTLQAR 550 560 570 580 590 600 FVKQIDFRPK DYLKHCLERS EFLLEKRIIQ SGIALLLMLI WYRPVAEFAQ SIQSRIVEWK 610 620 630 640 650 660 ERLDKEFSLS VYQKMKFNVA MGIGVLDWLR NSDDDDDDDS QENADKNEDG GEKNMEDSGH 670 680 690 700 710 ETGIDSQSQG SFQAPQPSQS SQSVHDHNQP YHICRGFTCF KKPPTPPPEP ET

References

[1]	"Recovery of strains of the polyomavirus SV40 from rhesus monkey kidney cells dating from the 1950s to the early 1960s." Peden K., Sheng L., Omeir R., Yacobucci M., Klutch M., Laassri M., Chumakov K., Pal A., Murata H., Lewis A.M.Jr. Virology 370:63-76(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SV40 EMBL ABU86079.1.
[2]	"Crystal structure of rice importin-? and structural basis of its interaction with plant-specific nuclear localization signals." Chang C.W., Counago R.L., Williams S.J., Boden M., Kobe B. Plant Cell 24:5074-5088(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF 125-132.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

EF579664 Genomic DNA. Translation: ABU86079.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4B8O	X-ray	2.08	B/C	125-132	[»]

ModBase

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Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

1.10.10.510. 1 hit.
1.10.287.110. 1 hit.

InterPro

IPR001623. DnaJ_domain.
IPR014015. Helicase_SF3_DNA-vir.
IPR016392. Lg_T_Ag_polyomavir.
IPR010932. Lg_T_Ag_Polyomavir_C.
IPR003133. T_Ag_DNA-bd.
IPR017910. Znf_lg_T-Ag_D1-typ.
[Graphical view]

Pfam

PF00226. DnaJ. 1 hit.
PF06431. Polyoma_lg_T_C. 1 hit.
PF02217. T_Ag_DNA_bind. 1 hit.
[Graphical view]

PIRSF

PIRSF003368. Large_T_antigen_polyomaV. 1 hit.

SMART

SM00271. DnaJ. 1 hit.
[Graphical view]

SUPFAM

SSF46565. DnaJ_N. 1 hit.

PROSITE

PS50076. DNAJ_2. 1 hit.
PS51206. SF3_HELICASE_1. 1 hit.
PS51287. T_AG_OBD. 1 hit.
PS51341. ZF_LTAG_D1. 1 hit.
[Graphical view]

ProtoNet

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Entry information

Entry name

A7XWN5_SV40

Accession

Primary (citable) accession number: A7XWN5

Entry history

Integrated into UniProtKB/TrEMBL:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)