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Protein

6-carboxyhexanoate--CoA ligase

Gene

bioW

Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.UniRule annotation

Catalytic activityi

ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: pimeloyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes pimeloyl-CoA from pimelate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 6-carboxyhexanoate--CoA ligase (bioW)
This subpathway is part of the pathway pimeloyl-CoA biosynthesis, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pimeloyl-CoA from pimelate, the pathway pimeloyl-CoA biosynthesis and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00999; UER00351.

Names & Taxonomyi

Protein namesi
Recommended name:
6-carboxyhexanoate--CoA ligaseUniRule annotation (EC:6.2.1.14UniRule annotation)
Alternative name(s):
Pimeloyl-CoA synthaseUniRule annotation
Gene namesi
Name:bioWUniRule annotation
Ordered Locus Names:SAHV_2407
OrganismiStaphylococcus aureus (strain Mu3 / ATCC 700698)
Taxonomic identifieri418127 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000446951 – 2306-carboxyhexanoate--CoA ligaseAdd BLAST230

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA7X666.
SMRiA7X666.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BioW family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000253976.
KOiK01906.
OMAiLCWSDDP.

Family and domain databases

HAMAPiMF_00668. BioW. 1 hit.
InterProiIPR005499. BioW.
[Graphical view]
PfamiPF03744. BioW. 1 hit.
[Graphical view]
ProDomiPD017229. BioW. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

A7X666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSIKMRSSN QDVHISGAET ICEFDKIEQT VQRFYNKGFF HENGQPDFLN
60 70 80 90 100
IKIQKIMEPI QQIKALQIIE DDKANLQHLT QECGVTEQAL NQGMTYIKNE
110 120 130 140 150
TVYTGAIILS AISGKRLDSF GQRGIRATHF SFEDINNKGD LNERVTDALA
160 170 180 190 200
IASCINAHPY VKGELCVSDD LTYTTGYFAA AKIGYHRLFD IKPVNTRYGG
210 220 230
RIIFVDDCID LNHYISFLES TPKQVVYETV
Length:230
Mass (Da):26,092
Last modified:October 23, 2007 - v1
Checksum:i345AB71E281355DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009324 Genomic DNA. Translation: BAF79290.1.
RefSeqiWP_000286875.1. NZ_CTYB01000005.1.

Genome annotation databases

EnsemblBacteriaiBAF79290; BAF79290; SAHV_2407.
GeneIDi28379960.
KEGGisaw:SAHV_2407.
PATRICi19560010. VBIStaAur127830_2471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009324 Genomic DNA. Translation: BAF79290.1.
RefSeqiWP_000286875.1. NZ_CTYB01000005.1.

3D structure databases

ProteinModelPortaliA7X666.
SMRiA7X666.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF79290; BAF79290; SAHV_2407.
GeneIDi28379960.
KEGGisaw:SAHV_2407.
PATRICi19560010. VBIStaAur127830_2471.

Phylogenomic databases

HOGENOMiHOG000253976.
KOiK01906.
OMAiLCWSDDP.

Enzyme and pathway databases

UniPathwayiUPA00999; UER00351.

Family and domain databases

HAMAPiMF_00668. BioW. 1 hit.
InterProiIPR005499. BioW.
[Graphical view]
PfamiPF03744. BioW. 1 hit.
[Graphical view]
ProDomiPD017229. BioW. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiBIOW_STAA1
AccessioniPrimary (citable) accession number: A7X666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.