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A7X656

- GPMA_STAA1

UniProt

A7X656 - GPMA_STAA1

Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

    Catalytic activityi

    2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei9 – 91Tele-phosphohistidine intermediateUniRule annotation
    Binding sitei15 – 1512-phospho-D-glycerateUniRule annotation
    Binding sitei60 – 6012-phospho-D-glycerateUniRule annotation
    Binding sitei98 – 9812-phospho-D-glycerateUniRule annotation
    Active sitei182 – 1821UniRule annotation
    Binding sitei184 – 18412-phospho-D-glycerateUniRule annotation

    GO - Molecular functioni

    1. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Glycolysis

    Enzyme and pathway databases

    BioCyciSAUR418127:GJP9-2470-MONOMER.
    UniPathwayiUPA00109; UER00186.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
    Short name:
    BPG-dependent PGAMUniRule annotation
    Short name:
    PGAMUniRule annotation
    Short name:
    PhosphoglyceromutaseUniRule annotation
    Short name:
    dPGMUniRule annotation
    Gene namesi
    Name:gpmAUniRule annotation
    Ordered Locus Names:SAHV_2400
    OrganismiStaphylococcus aureus (strain Mu3 / ATCC 700698)
    Taxonomic identifieri418127 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001130: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2282282,3-bisphosphoglycerate-dependent phosphoglycerate mutasePRO_1000064101Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi418127.SAHV_2400.

    Structurei

    3D structure databases

    ProteinModelPortaliA7X656.
    SMRiA7X656. Positions 1-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 2222-phospho-D-glycerate bindingUniRule annotation
    Regioni87 – 9042-phospho-D-glycerate bindingUniRule annotation
    Regioni114 – 11522-phospho-D-glycerate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0588.
    HOGENOMiHOG000221682.
    KOiK01834.
    OMAiKDDERFP.
    OrthoDBiEOG6C8N1H.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    HAMAPiMF_01039. PGAM_GpmA.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    IPR001345. PG/BPGM_mutase_AS.
    IPR005952. Phosphogly_mut1.
    [Graphical view]
    PANTHERiPTHR11931. PTHR11931. 1 hit.
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.
    TIGRFAMsiTIGR01258. pgm_1. 1 hit.
    PROSITEiPS00175. PG_MUTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7X656-1 [UniParc]FASTAAdd to Basket

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    MPKLILCRHG QSEWNAKNLF TGWEDVNLSE QGINEATRAG EKVRENNIAI    50
    DVAFTSLLTR ALDTTHYILT ESKQQWIPVY KSWRLNERHY GGLQGLNKDD 100
    ARKEFGEEQV HIWRRSYDVK PPAETEEQRE AYLADRRYNH LDKRMMPYSE 150
    SLKDTLVRVI PFWTDHISQY LLDGQTVLVS AHGNSIRALI KYLEDVSDED 200
    IINYEIKTGA PLVYELTDDL EVIDKYYL 228
    Length:228
    Mass (Da):26,680
    Last modified:October 23, 2007 - v1
    Checksum:i1751F3AFB1EE068E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009324 Genomic DNA. Translation: BAF79283.1.
    RefSeqiYP_001442990.1. NC_009782.1.

    Genome annotation databases

    EnsemblBacteriaiBAF79283; BAF79283; SAHV_2400.
    GeneIDi5559468.
    KEGGisaw:SAHV_2400.
    PATRICi19559996. VBIStaAur127830_2464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009324 Genomic DNA. Translation: BAF79283.1 .
    RefSeqi YP_001442990.1. NC_009782.1.

    3D structure databases

    ProteinModelPortali A7X656.
    SMRi A7X656. Positions 1-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 418127.SAHV_2400.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF79283 ; BAF79283 ; SAHV_2400 .
    GeneIDi 5559468.
    KEGGi saw:SAHV_2400.
    PATRICi 19559996. VBIStaAur127830_2464.

    Phylogenomic databases

    eggNOGi COG0588.
    HOGENOMi HOG000221682.
    KOi K01834.
    OMAi KDDERFP.
    OrthoDBi EOG6C8N1H.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00186 .
    BioCyci SAUR418127:GJP9-2470-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    HAMAPi MF_01039. PGAM_GpmA.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    IPR001345. PG/BPGM_mutase_AS.
    IPR005952. Phosphogly_mut1.
    [Graphical view ]
    PANTHERi PTHR11931. PTHR11931. 1 hit.
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    TIGRFAMsi TIGR01258. pgm_1. 1 hit.
    PROSITEi PS00175. PG_MUTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance."
      Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.
      Antimicrob. Agents Chemother. 52:45-53(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu3 / ATCC 700698.

    Entry informationi

    Entry nameiGPMA_STAA1
    AccessioniPrimary (citable) accession number: A7X656
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3