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A7X656

- GPMA_STAA1

UniProt

A7X656 - GPMA_STAA1

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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene
gpmA, SAHV_2400
Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91Tele-phosphohistidine intermediate By similarity
Binding sitei15 – 1512-phospho-D-glycerate By similarity
Binding sitei60 – 6012-phospho-D-glycerate By similarity
Binding sitei98 – 9812-phospho-D-glycerate By similarity
Active sitei182 – 1821 By similarity
Binding sitei184 – 18412-phospho-D-glycerate By similarity

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Enzyme and pathway databases

BioCyciSAUR418127:GJP9-2470-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (EC:5.4.2.11)
Short name:
BPG-dependent PGAM
Short name:
PGAM
Short name:
Phosphoglyceromutase
Short name:
dPGM
Gene namesi
Name:gpmA
Ordered Locus Names:SAHV_2400
OrganismiStaphylococcus aureus (strain Mu3 / ATCC 700698)
Taxonomic identifieri418127 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001130: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2282282,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotationPRO_1000064101Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi418127.SAHV_2400.

Structurei

3D structure databases

ProteinModelPortaliA7X656.
SMRiA7X656. Positions 1-228.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 2222-phospho-D-glycerate binding By similarity
Regioni87 – 9042-phospho-D-glycerate binding By similarity
Regioni114 – 11522-phospho-D-glycerate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0588.
HOGENOMiHOG000221682.
KOiK01834.
OMAiKDDERFP.
OrthoDBiEOG6C8N1H.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7X656-1 [UniParc]FASTAAdd to Basket

« Hide

MPKLILCRHG QSEWNAKNLF TGWEDVNLSE QGINEATRAG EKVRENNIAI    50
DVAFTSLLTR ALDTTHYILT ESKQQWIPVY KSWRLNERHY GGLQGLNKDD 100
ARKEFGEEQV HIWRRSYDVK PPAETEEQRE AYLADRRYNH LDKRMMPYSE 150
SLKDTLVRVI PFWTDHISQY LLDGQTVLVS AHGNSIRALI KYLEDVSDED 200
IINYEIKTGA PLVYELTDDL EVIDKYYL 228
Length:228
Mass (Da):26,680
Last modified:October 23, 2007 - v1
Checksum:i1751F3AFB1EE068E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009324 Genomic DNA. Translation: BAF79283.1.
RefSeqiYP_001442990.1. NC_009782.1.

Genome annotation databases

EnsemblBacteriaiBAF79283; BAF79283; SAHV_2400.
GeneIDi5559468.
KEGGisaw:SAHV_2400.
PATRICi19559996. VBIStaAur127830_2464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009324 Genomic DNA. Translation: BAF79283.1 .
RefSeqi YP_001442990.1. NC_009782.1.

3D structure databases

ProteinModelPortali A7X656.
SMRi A7X656. Positions 1-228.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 418127.SAHV_2400.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF79283 ; BAF79283 ; SAHV_2400 .
GeneIDi 5559468.
KEGGi saw:SAHV_2400.
PATRICi 19559996. VBIStaAur127830_2464.

Phylogenomic databases

eggNOGi COG0588.
HOGENOMi HOG000221682.
KOi K01834.
OMAi KDDERFP.
OrthoDBi EOG6C8N1H.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00186 .
BioCyci SAUR418127:GJP9-2470-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
HAMAPi MF_01039. PGAM_GpmA.
InterProi IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view ]
PANTHERi PTHR11931. PTHR11931. 1 hit.
Pfami PF00300. His_Phos_1. 1 hit.
[Graphical view ]
SMARTi SM00855. PGAM. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
TIGRFAMsi TIGR01258. pgm_1. 1 hit.
PROSITEi PS00175. PG_MUTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance."
    Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.
    Antimicrob. Agents Chemother. 52:45-53(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu3 / ATCC 700698.

Entry informationi

Entry nameiGPMA_STAA1
AccessioniPrimary (citable) accession number: A7X656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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