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Protein

Probable molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei18 – 181GTPUniRule annotation
Binding sitei65 – 651GTPUniRule annotation
Metal bindingi97 – 971MagnesiumUniRule annotation
Binding sitei97 – 971GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 83GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR418127:GJP9-2323-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:SAHV_2253
OrganismiStaphylococcus aureus (strain Mu3 / ATCC 700698)
Taxonomic identifieri418127 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Probable molybdenum cofactor guanylyltransferasePRO_1000019155Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA7X5J2.
SMRiA7X5J2. Positions 1-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000280425.
KOiK03752.
OMAiGLYHFMV.
OrthoDBiEOG66MQMC.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA.
InterProiIPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF12804. NTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

A7X5J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAIILAGGH SVRFGKPKAF AEVNGETFYS RVIKTLESTN MFNEIIISTN
60 70 80 90 100
AQLATQFKYP NVVIDDENHN DKGPLAGIYT IMKQHPEEEL FFVVSVDTPM
110 120 130 140 150
ITGKAVSTLY QFLVSHLIEN HLDVAAFKED GRFIPTIAFY SPNALGAITK
160 170 180 190
ALHSDNYSFK NIYHELSTDY LDVRDVDAPS YWYKNINYQH DLDALIQKL
Length:199
Mass (Da):22,556
Last modified:October 23, 2007 - v1
Checksum:iC79B67072F3321B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009324 Genomic DNA. Translation: BAF79136.1.
RefSeqiWP_000643986.1. NC_009782.1.

Genome annotation databases

EnsemblBacteriaiBAF79136; BAF79136; SAHV_2253.
KEGGisaw:SAHV_2253.
PATRICi19559692. VBIStaAur127830_2312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009324 Genomic DNA. Translation: BAF79136.1.
RefSeqiWP_000643986.1. NC_009782.1.

3D structure databases

ProteinModelPortaliA7X5J2.
SMRiA7X5J2. Positions 1-196.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF79136; BAF79136; SAHV_2253.
KEGGisaw:SAHV_2253.
PATRICi19559692. VBIStaAur127830_2312.

Phylogenomic databases

HOGENOMiHOG000280425.
KOiK03752.
OMAiGLYHFMV.
OrthoDBiEOG66MQMC.

Enzyme and pathway databases

BioCyciSAUR418127:GJP9-2323-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA.
InterProiIPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF12804. NTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance."
    Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.
    Antimicrob. Agents Chemother. 52:45-53(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu3 / ATCC 700698.

Entry informationi

Entry nameiMOBA_STAA1
AccessioniPrimary (citable) accession number: A7X5J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: March 16, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.