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A7X4W5 (A7X4W5_STAA1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidine kinase HAMAP MF_00124 RuleBase RU000544
EC=2.7.1.21 HAMAP MF_00124 RuleBase RU000544
Gene names
Name:tdk HAMAP MF_00124 EMBL BAF78986.1
Ordered Locus Names:SAHV_2103
OrganismStaphylococcus aureus (strain Mu3 / ATCC 700698) [Complete proteome] [HAMAP]
Taxonomic identifier418127 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP MF_00124 SAAS SAAS020634 RuleBase RU000544

Subunit structure

Homotetramer By similarity. HAMAP MF_00124 SAAS SAAS020634

Subcellular location

Cytoplasm By similarity HAMAP MF_00124 SAAS SAAS020634.

Sequence similarities

Belongs to the thymidine kinase family. HAMAP MF_00124 RuleBase RU004165

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding15 – 228ATP By similarity HAMAP MF_00124
Nucleotide binding88 – 914ATP By similarity HAMAP MF_00124

Sites

Active site891Proton acceptor By similarity HAMAP MF_00124
Metal binding1451Zinc By similarity HAMAP MF_00124
Metal binding1481Zinc By similarity HAMAP MF_00124
Metal binding1831Zinc By similarity HAMAP MF_00124
Metal binding1861Zinc By similarity HAMAP MF_00124

Sequences

Sequence LengthMass (Da)Tools
A7X4W5 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: C1E896BDC5645903

FASTA19922,213
        10         20         30         40         50         60 
MYETYHSGWI ECITGSMFSG KSEELIRRLR RGIYAKQKVV VFKPAIDDRY HKEKVVSHNG 

        70         80         90        100        110        120 
NAIEAINISK ASEIMTHNLT NVDVIGIDEV QFFDDEIVSI VEKLSADGHR VIVAGLDMDF 

       130        140        150        160        170        180 
RGEPFEPMPK LMAVSEQVTK LQAVCAVCGS SSSRTQRLIN GKPAKIDDPI ILVGANESYE 

       190 
PRCRAHHIVA PSDNNKEEL

« Hide

References

[1]"Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance."
Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.
Antimicrob. Agents Chemother. 52:45-53(2008) [PubMed: 17954695] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009324 Genomic DNA. Translation: BAF78986.1.
RefSeqYP_001442693.1. NC_009782.1.

3D structure databases

ProteinModelPortalA7X4W5.
SMRA7X4W5. Positions 1-189.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7X4W5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000003827; EBSTAP00000003726; EBSTAG00000003827.
GeneID5561597.
GenomeReviewsGene locus SAHV_2103 in contig AP009324_GR.
KEGGsaw:SAHV_2103.
PATRIC19559372. VBIStaAur127830_2161.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
GeneTreeEBGT00050000023861.
HOGENOMHBG522108.
OMAEPRCRHH.
ProtClustDBPRK04296.

Enzyme and pathway databases

BioCycSAUR418127:SAHV_2103-MONOMER.

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
[Tree]
InterProIPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
KOK00857.
PANTHERPTHR11441. TK_cell. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7X4W5_STAA1
AccessionPrimary (citable) accession number: A7X4W5
Entry history
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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