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Protein

Serine-protein kinase RsbW

Gene

rsbW

Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR418127:GJP9-2111-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-protein kinase RsbWUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Anti-sigma-B factorUniRule annotation
Sigma-B negative effector RsbWUniRule annotation
Gene namesi
Name:rsbWUniRule annotation
Ordered Locus Names:SAHV_2050
OrganismiStaphylococcus aureus (strain Mu3 / ATCC 700698)
Taxonomic identifieri418127 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Serine-protein kinase RsbWPRO_1000061448Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA7X4P1.
SMRiA7X4P1. Positions 8-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000269932.
KOiK04757.
OMAiKMGFSYE.
OrthoDBiEOG6S7XW5.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00638. Anti_sigma_B.
InterProiIPR003594. HATPase_C.
IPR010193. RsbW.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01924. rsbW_low_gc. 1 hit.

Sequencei

Sequence statusi: Complete.

A7X4P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSKEDFIEM RVPASAEYVS LIRLTLSGVF SRAGATYDDI EDAKIAVSEA
60 70 80 90 100
VTNAVKHAYK ENNNVGIINI YFEILEDKIK IVISDKGDSF DYETTKSKIG
110 120 130 140 150
PYDKDENIDF LREGGLGLFL IESLMDEVTV YKESGVTISM TKYIKKEQVR

NNGERVEIS
Length:159
Mass (Da):17,921
Last modified:October 23, 2007 - v1
Checksum:i57FA8EB8C1F9902B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009324 Genomic DNA. Translation: BAF78933.1.
RefSeqiWP_001190829.1. NZ_CTYB01000037.1.

Genome annotation databases

EnsemblBacteriaiBAF78933; BAF78933; SAHV_2050.
KEGGisaw:SAHV_2050.
PATRICi19559266. VBIStaAur127830_2108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009324 Genomic DNA. Translation: BAF78933.1.
RefSeqiWP_001190829.1. NZ_CTYB01000037.1.

3D structure databases

ProteinModelPortaliA7X4P1.
SMRiA7X4P1. Positions 8-149.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF78933; BAF78933; SAHV_2050.
KEGGisaw:SAHV_2050.
PATRICi19559266. VBIStaAur127830_2108.

Phylogenomic databases

HOGENOMiHOG000269932.
KOiK04757.
OMAiKMGFSYE.
OrthoDBiEOG6S7XW5.

Enzyme and pathway databases

BioCyciSAUR418127:GJP9-2111-MONOMER.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00638. Anti_sigma_B.
InterProiIPR003594. HATPase_C.
IPR010193. RsbW.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01924. rsbW_low_gc. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance."
    Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.
    Antimicrob. Agents Chemother. 52:45-53(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu3 / ATCC 700698.

Entry informationi

Entry nameiRSBW_STAA1
AccessioniPrimary (citable) accession number: A7X4P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: May 11, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.