A7X3E0 (ACKA_STAA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	SAHV_1697

Organism

Staphylococcus aureus (strain Mu3 / ATCC 700698) [Complete proteome] [HAMAP]

Taxonomic identifier

418127 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Acetate kinase HAMAP MF_00020		PRO_1000002262

Sequences

	Sequence		Length	Mass (Da)
	A7X3E0 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 32C8CC41D338187A	FASTA	400	44,041
	10 20 30 40 50 60 MSKLILAINA GSSSLKFQLI RMPEEELVTK GLIERIGLKD SIFTIEVNGE KVKTVQDIKD 70 80 90 100 110 120 HVEAVDIMLD AFKAHNIIND INDIVGTGHR VVHGGEKFPE SVAITDEVEK EIEELSELAP 130 140 150 160 170 180 LHNPANLMGI RAFRKLLPNI PHVAIFDTAF HQTMPEKAYL YSLPYHYYKD YGIRKYGFHG 190 200 210 220 230 240 TSHKFVSQRA AEMLDKPIED LRIISCHIGN GASIAAIDGG KSIDTSMGFT PLAGVTMGTR 250 260 270 280 290 300 SGNIDPALIP FIMEKTGKTA EQVLEILNKE SGLLGLSGTS SDLRDLSEEA ESGKARSQMA 310 320 330 340 350 360 LDVFASKIHK YIGSYAARMH GVDVIVFTAG IGENSVEIRA KVLEGLEFMG VYWDPKKNEN 370 380 390 400 LLRGKEGFIN YPHSPVKVVV IPTDEESMIA RDVMTFGGLK

References

[1]

"Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance." Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K. Antimicrob. Agents Chemother. 52:45-53(2008) [PubMed: 17954695] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Mu3 / ATCC 700698.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009324 Genomic DNA. Translation: BAF78580.1.
RefSeq	YP_001442287.1. NC_009782.1.
3D structure databases
ProteinModelPortal	A7X3E0.
SMR	A7X3E0. Positions 5-396.
ModBase	Search...
Protein-protein interaction databases
STRING	A7X3E0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000004350; EBSTAP00000004249; EBSTAG00000004350.
GeneID	5559162.
GenomeReviews	Gene locus SAHV_1697 in contig AP009324_GR.
KEGG	saw:SAHV_1697.
PATRIC	19558450. VBIStaAur127830_1743.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0282.
GeneTree	EBGT00050000024640.
HOGENOM	HBG285863.
OMA	LIDMTNE.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	SAUR418127:SAHV_1697-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_STAA1

Accession

Primary (citable) accession number: A7X3E0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program