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Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene

murD

Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).UniRule annotation

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi118 – 124ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
Alternative name(s):
D-glutamic acid-adding enzymeUniRule annotation
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUniRule annotation
Gene namesi
Name:murDUniRule annotation
Ordered Locus Names:SAHV_1173
OrganismiStaphylococcus aureus (strain Mu3 / ATCC 700698)
Taxonomic identifieri418127 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000568881 – 449UDP-N-acetylmuramoylalanine--D-glutamate ligaseAdd BLAST449

Structurei

3D structure databases

ProteinModelPortaliA7X1C4
SMRiA7X1C4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000049428
KOiK01925
OMAiVDKGNDY

Family and domain databases

Gene3Di3.40.1190.10, 1 hit
3.90.190.20, 1 hit
HAMAPiMF_00639 MurD, 1 hit
InterProiView protein in InterPro
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR005762 UDP-N-AcMur-Glu_ligase
PfamiView protein in Pfam
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
TIGRFAMsiTIGR01087 murD, 1 hit

Sequencei

Sequence statusi: Complete.

A7X1C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNYTGLENK NVLVVGLAKS GYEAAKLLSK LGANVTVNDG KDLSQDAHAK
60 70 80 90 100
DLESMGISVV SGSHPLTLLD NNPIIVKNPG IPYTVSIIDE AVKRGLKILT
110 120 130 140 150
EVELSYLISE APIIAVTGTN GKTTVTSLIG DMFKKSRLTG RLSGNIGYVA
160 170 180 190 200
SKVAQEVKPT DYLVTELSSF QLLGIEKYKP HIAIITNIYS AHLDYHENLE
210 220 230 240 250
NYQNAKKQIY KNQTEEDYLI CNYHQRQVIE SEELKAKTLY FSTQQEVDGI
260 270 280 290 300
YIKDGFIVYK GVRIINTEDL VLPGEHNLEN ILAAVLACIL AGVPIKAIID
310 320 330 340 350
SLTTFSGIEH RLQYVGTNRT NKYYNDSKAT NTLATQFALN SFNQPIIWLC
360 370 380 390 400
GGLDRGNEFD ELIPYMENVR AMVVFGQTKA KFAKLGNSQG KSVIEANNVE
410 420 430 440
DAVDKVQDII EPNDVVLLSP ACASWDQYST FEERGEKFIE RFRAHLPSY
Length:449
Mass (Da):49,844
Last modified:October 23, 2007 - v1
Checksum:i071BEEE9CF74F985
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009324 Genomic DNA Translation: BAF78056.1
RefSeqiWP_000935991.1, NZ_CTYB01000010.1

Genome annotation databases

EnsemblBacteriaiBAF78056; BAF78056; SAHV_1173
KEGGisaw:SAHV_1173

Similar proteinsi

Entry informationi

Entry nameiMURD_STAA1
AccessioniPrimary (citable) accession number: A7X1C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health