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A7X1C2 (MRAY_STAA1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:SAHV_1172
OrganismStaphylococcus aureus (strain Mu3 / ATCC 700698) [Complete proteome] [HAMAP]
Taxonomic identifier418127 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP-Rule MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP-Rule MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00038

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP-Rule MF_00038
PRO_1000003071

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane50 – 7021Helical; Potential
Transmembrane76 – 9621Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane250 – 27021Helical; Potential
Transmembrane300 – 32021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A7X1C2 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: 0A2F82D042255848

FASTA32135,232
        10         20         30         40         50         60 
MIFVYALLAL VITFVLVPVL IPTLKRMKFG QSIREEGPQS HMKKTGTPTM GGLTFLLSIV 

        70         80         90        100        110        120 
ITSLVAIIFV DQANPIILLL FVTIGFGLIG FIDDYIIVVK KNNQGLTSKQ KFLAQIGIAI 

       130        140        150        160        170        180 
IFFVLSNVFH LVNFSTSIHI PFTNVAIPLS FAYVIFIVFW QVGFSNAVNL TDGLDGLATG 

       190        200        210        220        230        240 
LSIIGFTMYA IMSFVLGETA IGIFCIIMLF ALLGFLPYNI NPAKVFMGDT GSLALGGIFA 

       250        260        270        280        290        300 
TISIMLNQEL SLIFIGLVFV IETLSVMLQV ASFKLTGKRI FKMSPIHHHF ELIGWSEWKV 

       310        320 
VTVFWAVGLI SGLIGLWIGV H

« Hide

References

[1]"Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance."
Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.
Antimicrob. Agents Chemother. 52:45-53(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Mu3 / ATCC 700698.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009324 Genomic DNA. Translation: BAF78055.1.
RefSeqYP_001441762.1. NC_009782.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING418127.SAHV_1172.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF78055; BAF78055; SAHV_1172.
GeneID5559384.
KEGGsaw:SAHV_1172.
PATRIC19557357. VBIStaAur127830_1196.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHOG000275124.
KOK01000.
OMAEYLTQFY.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycSAUR418127:GJP9-1191-MONOMER.
UniPathwayUPA00219.

Family and domain databases

HAMAPMF_00038. MraY.
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERPTHR22926. PTHR22926. 1 hit.
PTHR22926:SF3. PTHR22926:SF3. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. mraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBA7X1C2.

Entry information

Entry nameMRAY_STAA1
AccessionPrimary (citable) accession number: A7X1C2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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