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A7X0W4

- PUR5_STAA1

UniProt

A7X0W4 - PUR5_STAA1

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAUR418127:GJP9-1081-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:SAHV_1063
    OrganismiStaphylococcus aureus (strain Mu3 / ATCC 700698)
    Taxonomic identifieri418127 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001130: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000046474Add
    BLAST

    Proteomic databases

    PRIDEiA7X0W4.

    Interactioni

    Protein-protein interaction databases

    STRINGi418127.SAHV_1063.

    Structurei

    3D structure databases

    ProteinModelPortaliA7X0W4.
    SMRiA7X0W4. Positions 17-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiVIGKIEH.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7X0W4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKAYEQSGV NIHAGYEAVE RMSSHVKRTM RKEVIGGLGG FGATFDLSQL    50
    NMTAPVLVSG TDGVGTKLKL AIDYGKHDSI GIDAVAMCVN DILTTGAEPL 100
    YFLDYIATNK VVPEVIEQIV KGISDACVET NTALIGGETA EMGEMYHEGE 150
    YDVAGFAVGA VEKDDYVDGS EVKEGQVVIG LASSGIHSNG YSLVRKLINE 200
    SGIDLASNFD NRPFIDVFLE PTKLYVKPVL ALKKEVSIKA MNHITGGGFY 250
    ENIPRALPAG YAARIDTTSF PTPKIFDWLQ QQGNIDTNEM YNIFNMGIGY 300
    TVIVDEKDAS RALKILAEQN VEAYQIGHIV KNESTAIELL GV 342
    Length:342
    Mass (Da):36,989
    Last modified:October 23, 2007 - v1
    Checksum:i64574C39FB36508D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009324 Genomic DNA. Translation: BAF77946.1.
    RefSeqiYP_001441653.1. NC_009782.1.

    Genome annotation databases

    EnsemblBacteriaiBAF77946; BAF77946; SAHV_1063.
    GeneIDi5561044.
    KEGGisaw:SAHV_1063.
    PATRICi19557125. VBIStaAur127830_1081.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009324 Genomic DNA. Translation: BAF77946.1 .
    RefSeqi YP_001441653.1. NC_009782.1.

    3D structure databases

    ProteinModelPortali A7X0W4.
    SMRi A7X0W4. Positions 17-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 418127.SAHV_1063.

    Proteomic databases

    PRIDEi A7X0W4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF77946 ; BAF77946 ; SAHV_1063 .
    GeneIDi 5561044.
    KEGGi saw:SAHV_1063.
    PATRICi 19557125. VBIStaAur127830_1081.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi VIGKIEH.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci SAUR418127:GJP9-1081-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance."
      Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.
      Antimicrob. Agents Chemother. 52:45-53(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu3 / ATCC 700698.

    Entry informationi

    Entry nameiPUR5_STAA1
    AccessioniPrimary (citable) accession number: A7X0W4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3