A7X0N7 (A7X0N7_STAA1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADPH] PIRNR PIRNR000094
Short name=ENR PIRNR PIRNR000094
EC=1.3.1.10 PIRNR PIRNR000094

Gene names

Name:	fabI EMBL BAF77888.1
Ordered Locus Names:	SAHV_1005

Organism

Staphylococcus aureus (strain Mu3 / ATCC 700698) [Complete proteome] [HAMAP]

Taxonomic identifier

418127 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acyl-[acyl-carrier-protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADPH. PIRNR PIRNR000094
Pathway	Lipid metabolism; fatty acid biosynthesis. PIRNR PIRNR000094
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. PIRNR PIRNR000094

Ontologies

Keywords
Biological process	Fatty acid biosynthesis PIRNR PIRNR000094 Lipid synthesis
Ligand	NAD PIRNR PIRNR000094
Molecular function	Oxidoreductase PIRNR PIRNR000094
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	enoyl-[acyl-carrier-protein] reductase (NADH) activity Inferred from electronic annotation. Source: InterPro enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	157	1	Proton acceptor By similarity PIRSR PIRSR000094-1

Sequences

	Sequence		Length	Mass (Da)
	A7X0N7 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 69487F3F410B9A15	FASTA	256	27,992
	10 20 30 40 50 60 MLNLENKTYV IMGIANKRSI AFGVAKVLDQ LGAKLVFTYR KERSRKELEK LLEQLNQPEA 70 80 90 100 110 120 HLYQIDVQSD EEVINGFEQI GKDVGNIDGV YHSIAFANME DLRGRFSETS REGFLLAQDI 130 140 150 160 170 180 SSYSLTIVAH EAKKLMPEGG SIVATTYLGG EFAVQNYNVM GVAKASLEAN VKYLALDLGP 190 200 210 220 230 240 DNIRVNAISA GPIRTLSAKG VGGFNTILKE IEERAPLKRN VDQVEVGKTA AYLLSDLSSG 250 VTGENIHVDS GFHAIK

References

[1]

"Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance." Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K. Antimicrob. Agents Chemother. 52:45-53(2008) [PubMed: 17954695] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009324 Genomic DNA. Translation: BAF77888.1.
RefSeq	YP_001441595.1. NC_009782.1.
3D structure databases
ProteinModelPortal	A7X0N7.
ModBase	Search...
Protein-protein interaction databases
STRING	A7X0N7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000003314; EBSTAP00000003213; EBSTAG00000003314.
GeneID	5560643.
GenomeReviews	Gene locus SAHV_1005 in contig AP009324_GR.
KEGG	saw:SAHV_1005.
PATRIC	19556998. VBIStaAur127830_1020.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0623.
GeneTree	EBGT00050000023865.
HOGENOM	HBG750976.
OMA	KKWDGLD.
ProtClustDB	PRK08594.
Enzyme and pathway databases
BioCyc	SAUR418127:SAHV_1005-MONOMER.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR014358. Enoyl-ACP_Rdtase_NADH. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00208.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PIRSF	PIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTS	PR00081. GDHRDH.
ProtoNet	Search...

Entry information

Entry name

A7X0N7_STAA1

Accession

Primary (citable) accession number: A7X0N7

Entry history

Integrated into UniProtKB/TrEMBL:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)