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A7X0N2

- NADK_STAA1

UniProt

A7X0N2 - NADK_STAA1

Protein

NAD kinase

Gene

nadK

Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451Proton acceptorUniRule annotation
    Binding sitei149 – 1491NADUniRule annotation
    Binding sitei151 – 1511NADUniRule annotation
    Binding sitei186 – 1861NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi45 – 462NADUniRule annotation
    Nucleotide bindingi122 – 1232NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAUR418127:GJP9-1017-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:SAHV_1001
    OrganismiStaphylococcus aureus (strain Mu3 / ATCC 700698)
    Taxonomic identifieri418127 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001130: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269NAD kinasePRO_1000005444Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi418127.SAHV_1001.

    Structurei

    3D structure databases

    ProteinModelPortaliA7X0N2.
    SMRiA7X0N2. Positions 1-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000275803.
    KOiK00858.
    OMAiWRADELE.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7X0N2-1 [UniParc]FASTAAdd to Basket

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    MRYTILTKGD SKSNALKHKM MNYMKDFRMI EDSENPEIVI SVGGDGTLLQ    50
    AFHQYSHMLS KVAFVGVHTG HLGFYADWLP HEVEKLIIEI NNSEFQVIEY 100
    PLLEIIMRYN DNGYETRYLA LNEATMKTEN GSTLVVDVNL RGKHFERFRG 150
    DGLCVSTPSG STAYNKALGG ALIHPSLEAM QITEIASINN RVFRTVGSPL 200
    VLPKHHTCLI SPVNHDTIRM TIDHVSIKHK NVNSIQYRVA NEKVRFARFR 250
    PFPFWKRVHD SFISSDEER 269
    Length:269
    Mass (Da):30,769
    Last modified:October 23, 2007 - v1
    Checksum:iDC51C17C51D7F7FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009324 Genomic DNA. Translation: BAF77884.1.
    RefSeqiYP_001441591.1. NC_009782.1.

    Genome annotation databases

    EnsemblBacteriaiBAF77884; BAF77884; SAHV_1001.
    GeneIDi5559571.
    KEGGisaw:SAHV_1001.
    PATRICi19556990. VBIStaAur127830_1016.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009324 Genomic DNA. Translation: BAF77884.1 .
    RefSeqi YP_001441591.1. NC_009782.1.

    3D structure databases

    ProteinModelPortali A7X0N2.
    SMRi A7X0N2. Positions 1-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 418127.SAHV_1001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF77884 ; BAF77884 ; SAHV_1001 .
    GeneIDi 5559571.
    KEGGi saw:SAHV_1001.
    PATRICi 19556990. VBIStaAur127830_1016.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000275803.
    KOi K00858.
    OMAi WRADELE.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci SAUR418127:GJP9-1017-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance."
      Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.
      Antimicrob. Agents Chemother. 52:45-53(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu3 / ATCC 700698.

    Entry informationi

    Entry nameiNADK_STAA1
    AccessioniPrimary (citable) accession number: A7X0N2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3