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A7X0N2

- NADK_STAA1

UniProt

A7X0N2 - NADK_STAA1

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Protein

NAD kinase

Gene
nadK, SAHV_1001
Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptor By similarity
Binding sitei149 – 1491NAD By similarity
Binding sitei151 – 1511NAD By similarity
Binding sitei186 – 1861NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 462NAD By similarity
Nucleotide bindingi122 – 1232NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR418127:GJP9-1017-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:SAHV_1001
OrganismiStaphylococcus aureus (strain Mu3 / ATCC 700698)
Taxonomic identifieri418127 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001130: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269NAD kinaseUniRule annotationPRO_1000005444Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi418127.SAHV_1001.

Structurei

3D structure databases

ProteinModelPortaliA7X0N2.
SMRiA7X0N2. Positions 1-263.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000275803.
KOiK00858.
OMAiWRADELE.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A7X0N2-1 [UniParc]FASTAAdd to Basket

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MRYTILTKGD SKSNALKHKM MNYMKDFRMI EDSENPEIVI SVGGDGTLLQ    50
AFHQYSHMLS KVAFVGVHTG HLGFYADWLP HEVEKLIIEI NNSEFQVIEY 100
PLLEIIMRYN DNGYETRYLA LNEATMKTEN GSTLVVDVNL RGKHFERFRG 150
DGLCVSTPSG STAYNKALGG ALIHPSLEAM QITEIASINN RVFRTVGSPL 200
VLPKHHTCLI SPVNHDTIRM TIDHVSIKHK NVNSIQYRVA NEKVRFARFR 250
PFPFWKRVHD SFISSDEER 269
Length:269
Mass (Da):30,769
Last modified:October 23, 2007 - v1
Checksum:iDC51C17C51D7F7FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009324 Genomic DNA. Translation: BAF77884.1.
RefSeqiYP_001441591.1. NC_009782.1.

Genome annotation databases

EnsemblBacteriaiBAF77884; BAF77884; SAHV_1001.
GeneIDi5559571.
KEGGisaw:SAHV_1001.
PATRICi19556990. VBIStaAur127830_1016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009324 Genomic DNA. Translation: BAF77884.1 .
RefSeqi YP_001441591.1. NC_009782.1.

3D structure databases

ProteinModelPortali A7X0N2.
SMRi A7X0N2. Positions 1-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 418127.SAHV_1001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF77884 ; BAF77884 ; SAHV_1001 .
GeneIDi 5559571.
KEGGi saw:SAHV_1001.
PATRICi 19556990. VBIStaAur127830_1016.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000275803.
KOi K00858.
OMAi WRADELE.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci SAUR418127:GJP9-1017-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance."
    Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.
    Antimicrob. Agents Chemother. 52:45-53(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu3 / ATCC 700698.

Entry informationi

Entry nameiNADK_STAA1
AccessioniPrimary (citable) accession number: A7X0N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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