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Protein

Sensor histidine kinase GraS

Gene

graS

Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). GraS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to GraR (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAntibiotic resistance, Two-component regulatory system, Virulence
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor histidine kinase GraS (EC:2.7.13.3)
Alternative name(s):
Glycopeptide resistance-associated protein S
Gene namesi
Name:graS
Ordered Locus Names:SAHV_0657
OrganismiStaphylococcus aureus (strain Mu3 / ATCC 700698)
Taxonomic identifieri418127 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003479191 – 346Sensor histidine kinase GraSAdd BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei129Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA7WZC5

Structurei

3D structure databases

ProteinModelPortaliA7WZC5
SMRiA7WZC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 332Histidine kinasePROSITE-ProRule annotationAdd BLAST207

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000032012
KOiK19077
OMAiYEWLRIH

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR036097 HisK_dim/P_sf
IPR004358 Sig_transdc_His_kin-like_C
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit

Sequencei

Sequence statusi: Complete.

A7WZC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLKWVAYF LKSRMNWIFW ILFLNLLMLG ISLIDYDFPI DSLFYIVSLN
60 70 80 90 100
LSLTMIFLIL TYFKEVKLYK HFDKDKEIEE IKHKDLAETP FQRHTVDYLY
110 120 130 140 150
RQISAHKEKV VEQQLQLNMH EQTITEFVHD IKTPVTAMKL LIDQEKNQER
160 170 180 190 200
KQALLYEWSR INSMLDTQLY ITRLESQRKD MYFDYVSLKR MVIDEIQLTR
210 220 230 240 250
HISQVKGIGF DVDFKVDDYV YTDTKWCRMI IRQILSNALK YSENFNIEIG
260 270 280 290 300
TELNDQHVSL YIKDYGRGIS KKDMPRIFER GFTSTANRNE TTSSGMGLYL
310 320 330 340
VNSVKDQLGI HLQVTSTVGK GTTVRLIFPL QNEIVERMSE VTNLSF
Length:346
Mass (Da):41,032
Last modified:October 23, 2007 - v1
Checksum:i42952E007DD7CDA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009324 Genomic DNA Translation: BAF77540.1
RefSeqiWP_001061264.1, NC_009782.1

Genome annotation databases

EnsemblBacteriaiBAF77540; BAF77540; SAHV_0657
KEGGisaw:SAHV_0657

Similar proteinsi

Entry informationi

Entry nameiGRAS_STAA1
AccessioniPrimary (citable) accession number: A7WZC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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