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A7WZ02

- GCH4_STAA1

UniProt

A7WZ02 - GCH4_STAA1

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, SAHV_0564
Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei176 – 1761May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSAUR418127:GJP9-581-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:SAHV_0564
OrganismiStaphylococcus aureus (strain Mu3 / ATCC 700698)
Taxonomic identifieri418127 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001130: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292GTP cyclohydrolase FolE2UniRule annotation
PRO_1000068670Add
BLAST

Proteomic databases

PRIDEiA7WZ02.

Interactioni

Protein-protein interaction databases

STRINGi418127.SAHV_0564.

Structurei

3D structure databases

ProteinModelPortaliA7WZ02.
SMRiA7WZ02. Positions 47-290.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

A7WZ02-1 [UniParc]FASTAAdd to Basket

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MTEFDLSTRE GRWKHFGSVD PIEGTKPTTK NEMTDLQSTH KDFLFEIEEV    50
GIKNLVYPVL VDQYQTAGTF SFSTSLTKDE KGINMSRIIE SVEKHYDNGI 100
ELEFNTLYQV LRTLQTNMKQ NAAGVDVSGK WFFDRYSPTT NIKAVGNADV 150
TYGLAIDGDK VTRKELTIEA TVTTLCPCSK EISEYSAHNQ RGVVTVKTYI 200
NKDQNIVDDY KNKILDAMEA NASSILYPIL KRPDEKRVTE RAYENPRFVE 250
DLIRLIAADL VEFDWLDGFD IECRNEESIH QHDAFAKLKY RK 292
Length:292
Mass (Da):33,481
Last modified:October 23, 2007 - v1
Checksum:i78EAF10A9A42553B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009324 Genomic DNA. Translation: BAF77447.1.
RefSeqiYP_001441154.1. NC_009782.1.

Genome annotation databases

EnsemblBacteriaiBAF77447; BAF77447; SAHV_0564.
GeneIDi5559000.
KEGGisaw:SAHV_0564.
PATRICi19556097. VBIStaAur127830_0569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009324 Genomic DNA. Translation: BAF77447.1 .
RefSeqi YP_001441154.1. NC_009782.1.

3D structure databases

ProteinModelPortali A7WZ02.
SMRi A7WZ02. Positions 47-290.
ModBasei Search...

Protein-protein interaction databases

STRINGi 418127.SAHV_0564.

Proteomic databases

PRIDEi A7WZ02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF77447 ; BAF77447 ; SAHV_0564 .
GeneIDi 5559000.
KEGGi saw:SAHV_0564.
PATRICi 19556097. VBIStaAur127830_0569.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci SAUR418127:GJP9-581-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance."
    Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.
    Antimicrob. Agents Chemother. 52:45-53(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu3 / ATCC 700698.

Entry informationi

Entry nameiGCH4_STAA1
AccessioniPrimary (citable) accession number: A7WZ02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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