A7WYW1 (RL1_STAA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L1

Gene names

Name:	rplA
Ordered Locus Names:	SAHV_0536

Organism

Staphylococcus aureus (strain Mu3 / ATCC 700698) [Complete proteome] [HAMAP]

Taxonomic identifier

418127 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release By similarity. HAMAP MF_01318_B Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA By similarity. HAMAP MF_01318_B
Subunit structure	Part of the 50S ribosomal subunit.
Sequence similarities	Belongs to the ribosomal protein L1P family.

Ontologies

Keywords
Biological process	Translation regulation
Ligand	RNA-binding rRNA-binding tRNA-binding
Molecular function	Repressor Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW translation Inferred from electronic annotation. Source: InterPro
Cellular component	large ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	50S ribosomal protein L1 HAMAP MF_01318_B		PRO_1000051925

Sequences

	Sequence		Length	Mass (Da)
	A7WYW1 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: 0A1DD057E8A89EA6	FASTA	230	24,708
	10 20 30 40 50 60 MAKKGKKYQE AASKVDRTQH YSVEEAIKLA KETSIANFDA SVEVAFRLGI DTRKNDQQIR 70 80 90 100 110 120 GAVVLPNGTG KSQSVLVFAK GDKIAEAEAA GADYVGEAEY VQKIQQGWFD FDVVVATPDM 130 140 150 160 170 180 MGEVGKLGRV LGPKGLMPNP KTGTVTMDVK KAVEEIKAGK VEYRAEKAGI VHASIGKVSF 190 200 210 220 230 TDEQLIENFN TLQDVLAKAK PSSAKGTYFK SVAVTTTMGP GVKIDTASFK

References

[1]

"Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance." Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K. Antimicrob. Agents Chemother. 52:45-53(2008) [PubMed: 17954695] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Mu3 / ATCC 700698.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009324 Genomic DNA. Translation: BAF77419.1.
RefSeq	YP_001441126.1. NC_009782.1.
3D structure databases
ProteinModelPortal	A7WYW1.
SMR	A7WYW1. Positions 6-228.
ModBase	Search...
Protein-protein interaction databases
STRING	A7WYW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000004866; EBSTAP00000004765; EBSTAG00000004865.
GeneID	5559768.
GenomeReviews	Gene locus SAHV_0536 in contig AP009324_GR.
KEGG	saw:SAHV_0536.
PATRIC	19556041. VBIStaAur127830_0541.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0081.
GeneTree	EBGT00050000024312.
HOGENOM	HBG297400.
OMA	KAGTVTM.
ProtClustDB	PRK05424.
Enzyme and pathway databases
BioCyc	SAUR418127:SAHV_0536-MONOMER.
Family and domain databases
HAMAP	MF_01318_B. Ribosomal_L1_B. [Tree]
InterPro	IPR005878. Ribosom_L1_bac-type. IPR002143. Ribosomal_L1. IPR016094. Ribosomal_L1_2-a/b-sand. IPR016095. Ribosomal_L1_3-a/b-sand. IPR023673. Ribosomal_L1_CS. IPR023674. Ribosomal_L1_SF. [Graphical view]
Gene3D	G3DSA:3.30.190.20. Ribosomal_L1_2-a/b-sand. 2 hits. G3DSA:3.40.50.790. Ribosomal_L1_3-a/b-sand. 1 hit.
KO	K02863.
Pfam	PF00687. Ribosomal_L1. 1 hit. [Graphical view]
PIRSF	PIRSF002155. Ribosomal_L1. 1 hit.
SUPFAM	SSF56808. Ribosomal_L1. 1 hit.
TIGRFAMs	TIGR01169. RplA_bact. 1 hit.
PROSITE	PS01199. RIBOSOMAL_L1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL1_STAA1

Accession

Primary (citable) accession number: A7WYW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program