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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi156 – 163ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotation
Ordered Locus Names:SAHV_0001
OrganismiStaphylococcus aureus (strain Mu3 / ATCC 700698)
Taxonomic identifieri418127 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000487311 – 453Chromosomal replication initiator protein DnaAAdd BLAST453

Structurei

3D structure databases

ProteinModelPortaliA7WWM4.
SMRiA7WWM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000235658.
KOiK02313.
OMAiSHACDKI.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7WWM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKEIWEKV LEIAQEKLSA VSYSTFLKDT ELYTIKDGEA IVLSSIPFNA
60 70 80 90 100
NWLNQQYAEI IQAILFDVVG YEVKPHFITT EELANYSNNE TATPKETTKP
110 120 130 140 150
STETTEDNHV LGREQFNAHN TFDTFVIGPG NRFPHAASLA VAEAPAKAYN
160 170 180 190 200
PLFIYGGVGL GKTHLMHAIG HHVLDNNPDA KVIYTSSEKF TNEFIKSIRD
210 220 230 240 250
NEGEAFRERY RNIDVLLIDD IQFIQNKVQT QEEFFYTFNE LHQNNKQIVI
260 270 280 290 300
SSDRPPKEIA QLEDRLRSRF EWGLIVDITP PDYETRMAIL QKKIEEEKLD
310 320 330 340 350
IPPEALNYIA NQIQSNIREL EGALTRLLAY SQLLGKPITT ELTAEALKDI
360 370 380 390 400
IQAPKSKKIT IQDIQKIVGQ YYNVRIEDFS AKKRTKSIAY PRQIAMYLSR
410 420 430 440 450
ELTDFSLPKI GEEFGGRDHT TVIHAHEKIS KDLKEDPIFK QEVENLEKEI

RNV
Length:453
Mass (Da):51,966
Last modified:October 23, 2007 - v1
Checksum:iFD182A5E25F9ABD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009324 Genomic DNA. Translation: BAF76884.1.
RefSeqiWP_001290433.1. NC_009782.1.

Genome annotation databases

EnsemblBacteriaiBAF76884; BAF76884; SAHV_0001.
GeneIDi28379638.
KEGGisaw:SAHV_0001.
PATRICi19554922. VBIStaAur127830_0001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009324 Genomic DNA. Translation: BAF76884.1.
RefSeqiWP_001290433.1. NC_009782.1.

3D structure databases

ProteinModelPortaliA7WWM4.
SMRiA7WWM4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF76884; BAF76884; SAHV_0001.
GeneIDi28379638.
KEGGisaw:SAHV_0001.
PATRICi19554922. VBIStaAur127830_0001.

Phylogenomic databases

HOGENOMiHOG000235658.
KOiK02313.
OMAiSHACDKI.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAA_STAA1
AccessioniPrimary (citable) accession number: A7WWM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.