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Protein

Sex-determining region Y protein

Gene

SRY

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transcriptional regulator that controls a genetic switch in male development.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotationSAAS annotation

Keywords - Biological processi

Differentiation, Sexual differentiationUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

Calmodulin-bindingSAAS annotation, DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-determining region Y proteinUniRule annotationSAAS annotation
Gene namesi
Name:SRYImported
ORF Names:hCG_1733150Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36135.

Expressioni

Gene expression databases

BgeeiENSG00000184895.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000372547.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 128HMG box DNA-bindingInterPro annotationAdd BLAST69

Sequence similaritiesi

Belongs to the SRY family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG410XT0K. LUCA.
HOVERGENiHBG008712.
KOiK09266.
OMAiVWSRDQR.
OrthoDBiEOG091G0JDD.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017253. SRY.
[Graphical view]
PANTHERiPTHR10270:SF199. PTHR10270:SF199. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFiPIRSF037653. SRY. 1 hit.
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7WPU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSYASAMLS VFNSDDYSPA VQENIPALRR SSSFLCTESC NSKYQCETGE
60 70 80 90 100
NSKGNVQDRV KRPMNAFIVW SRDQRRKMAL ENPRMRNSEI SKQLGYQWKM
110 120 130 140 150
LTEAEKWPFF QEAQKLQAMH REKYPNYKYR PRRKAKMLPK NCSLLPADPA
160 170 180 190 200
SVLCSEVQLD NRLYRDDCTK ATHSRMEHQL GHLPPINAAS SPQQRDRYSH

WTKL
Length:204
Mass (Da):23,884
Last modified:October 23, 2007 - v1
Checksum:i84323C30A9C2173E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ811904 Genomic DNA. Translation: AFG33929.1.
JQ811905 Genomic DNA. Translation: AFG33930.1.
JQ811906 Genomic DNA. Translation: AFG33931.1.
JQ811907 Genomic DNA. Translation: AFG33932.1.
JQ811908 Genomic DNA. Translation: AFG33933.1.
JQ811909 Genomic DNA. Translation: AFG33934.1.
JQ811910 Genomic DNA. Translation: AFG33935.1.
JQ811911 Genomic DNA. Translation: AFG33936.1.
JQ811913 Genomic DNA. Translation: AFG33937.1.
JQ811915 Genomic DNA. Translation: AFG33938.1.
JQ811916 Genomic DNA. Translation: AFG33939.1.
JQ811917 Genomic DNA. Translation: AFG33940.1.
JQ811919 Genomic DNA. Translation: AFG33942.1.
JQ811922 Genomic DNA. Translation: AFG33944.1.
JQ811923 Genomic DNA. Translation: AFG33945.1.
JQ811924 Genomic DNA. Translation: AFG33946.1.
JQ811925 Genomic DNA. Translation: AFG33947.1.
JQ811926 Genomic DNA. Translation: AFG33948.1.
JQ811927 Genomic DNA. Translation: AFG33949.1.
JQ811928 Genomic DNA. Translation: AFG33950.1.
JQ811929 Genomic DNA. Translation: AFG33951.1.
JQ811930 Genomic DNA. Translation: AFG33952.1.
JQ811933 Genomic DNA. Translation: AFG33954.1.
JQ811934 Genomic DNA. Translation: AFG33955.1.
KF413436 Genomic DNA. Translation: AGZ62969.1.
KF413440 Genomic DNA. Translation: AGZ62973.1.
AM884747 Genomic DNA. Translation: CAP05198.1.
AM884750 Genomic DNA. Translation: CAP05201.1.
FN568067 Genomic DNA. Translation: CBH40188.1.
FN568068 Genomic DNA. Translation: CBH40189.1.
FN568069 Genomic DNA. Translation: CBH40190.1.
FN568070 Genomic DNA. Translation: CBH40191.1.
FN568071 Genomic DNA. Translation: CBH40192.1.
FN568073 Genomic DNA. Translation: CBH40194.1.
FN568074 Genomic DNA. Translation: CBH40195.1.
FN568075 Genomic DNA. Translation: CBH40196.1.
FN568076 Genomic DNA. Translation: CBH40197.1.
FN568077 Genomic DNA. Translation: CBH40198.1.
FN568078 Genomic DNA. Translation: CBH40199.1.
FN568079 Genomic DNA. Translation: CBH40200.1.
FN568080 Genomic DNA. Translation: CBH40201.1.
FN568081 Genomic DNA. Translation: CBH40202.1.
FN568082 Genomic DNA. Translation: CBH40203.1.
FN568083 Genomic DNA. Translation: CBH40204.1.
FN568084 Genomic DNA. Translation: CBH40205.1.
FN568085 Genomic DNA. Translation: CBH40206.1.
FN568086 Genomic DNA. Translation: CBH40207.1.
FN568087 Genomic DNA. Translation: CBH40208.1.
FN568088 Genomic DNA. Translation: CBH40209.1.
CH471115 Genomic DNA. Translation: EAX02769.1.
RefSeqiNP_003131.1. NM_003140.2.
UniGeneiHs.1992.

Genome annotation databases

GeneIDi6736.
KEGGihsa:6736.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ811904 Genomic DNA. Translation: AFG33929.1.
JQ811905 Genomic DNA. Translation: AFG33930.1.
JQ811906 Genomic DNA. Translation: AFG33931.1.
JQ811907 Genomic DNA. Translation: AFG33932.1.
JQ811908 Genomic DNA. Translation: AFG33933.1.
JQ811909 Genomic DNA. Translation: AFG33934.1.
JQ811910 Genomic DNA. Translation: AFG33935.1.
JQ811911 Genomic DNA. Translation: AFG33936.1.
JQ811913 Genomic DNA. Translation: AFG33937.1.
JQ811915 Genomic DNA. Translation: AFG33938.1.
JQ811916 Genomic DNA. Translation: AFG33939.1.
JQ811917 Genomic DNA. Translation: AFG33940.1.
JQ811919 Genomic DNA. Translation: AFG33942.1.
JQ811922 Genomic DNA. Translation: AFG33944.1.
JQ811923 Genomic DNA. Translation: AFG33945.1.
JQ811924 Genomic DNA. Translation: AFG33946.1.
JQ811925 Genomic DNA. Translation: AFG33947.1.
JQ811926 Genomic DNA. Translation: AFG33948.1.
JQ811927 Genomic DNA. Translation: AFG33949.1.
JQ811928 Genomic DNA. Translation: AFG33950.1.
JQ811929 Genomic DNA. Translation: AFG33951.1.
JQ811930 Genomic DNA. Translation: AFG33952.1.
JQ811933 Genomic DNA. Translation: AFG33954.1.
JQ811934 Genomic DNA. Translation: AFG33955.1.
KF413436 Genomic DNA. Translation: AGZ62969.1.
KF413440 Genomic DNA. Translation: AGZ62973.1.
AM884747 Genomic DNA. Translation: CAP05198.1.
AM884750 Genomic DNA. Translation: CAP05201.1.
FN568067 Genomic DNA. Translation: CBH40188.1.
FN568068 Genomic DNA. Translation: CBH40189.1.
FN568069 Genomic DNA. Translation: CBH40190.1.
FN568070 Genomic DNA. Translation: CBH40191.1.
FN568071 Genomic DNA. Translation: CBH40192.1.
FN568073 Genomic DNA. Translation: CBH40194.1.
FN568074 Genomic DNA. Translation: CBH40195.1.
FN568075 Genomic DNA. Translation: CBH40196.1.
FN568076 Genomic DNA. Translation: CBH40197.1.
FN568077 Genomic DNA. Translation: CBH40198.1.
FN568078 Genomic DNA. Translation: CBH40199.1.
FN568079 Genomic DNA. Translation: CBH40200.1.
FN568080 Genomic DNA. Translation: CBH40201.1.
FN568081 Genomic DNA. Translation: CBH40202.1.
FN568082 Genomic DNA. Translation: CBH40203.1.
FN568083 Genomic DNA. Translation: CBH40204.1.
FN568084 Genomic DNA. Translation: CBH40205.1.
FN568085 Genomic DNA. Translation: CBH40206.1.
FN568086 Genomic DNA. Translation: CBH40207.1.
FN568087 Genomic DNA. Translation: CBH40208.1.
FN568088 Genomic DNA. Translation: CBH40209.1.
CH471115 Genomic DNA. Translation: EAX02769.1.
RefSeqiNP_003131.1. NM_003140.2.
UniGeneiHs.1992.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000372547.

Protocols and materials databases

DNASUi6736.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6736.
KEGGihsa:6736.

Organism-specific databases

CTDi6736.
PharmGKBiPA36135.

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG410XT0K. LUCA.
HOVERGENiHBG008712.
KOiK09266.
OMAiVWSRDQR.
OrthoDBiEOG091G0JDD.

Miscellaneous databases

GenomeRNAii6736.

Gene expression databases

BgeeiENSG00000184895.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017253. SRY.
[Graphical view]
PANTHERiPTHR10270:SF199. PTHR10270:SF199. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFiPIRSF037653. SRY. 1 hit.
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA7WPU8_HUMAN
AccessioniPrimary (citable) accession number: A7WPU8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.