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Protein

Sex-determining region Y protein

Gene

SRY

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcriptional regulator that controls a genetic switch in male development.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi60 – 128HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotationSAAS annotation, Calmodulin-bindingSAAS annotation, DNA-bindingUniRule annotationSAAS annotation
Biological processDifferentiation, Sexual differentiationUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-determining region Y proteinUniRule annotationSAAS annotation
Gene namesi
Name:SRYImported
ORF Names:hCG_1733150Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000184895.7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36135

Expressioni

Gene expression databases

BgeeiENSG00000184895
ExpressionAtlasiA7WPU8 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiA7WPU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 128HMG boxInterPro annotationAdd BLAST69

Sequence similaritiesi

Belongs to the SRY family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG410XT0K LUCA
HOVERGENiHBG008712
KOiK09266
OMAiDCTKATH
OrthoDBiEOG091G0JDD

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR017253 SRY
PANTHERiPTHR10270:SF199 PTHR10270:SF199, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PIRSFiPIRSF037653 SRY, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

A7WPU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSYASAMLS VFNSDDYSPA VQENIPALRR SSSFLCTESC NSKYQCETGE
60 70 80 90 100
NSKGNVQDRV KRPMNAFIVW SRDQRRKMAL ENPRMRNSEI SKQLGYQWKM
110 120 130 140 150
LTEAEKWPFF QEAQKLQAMH REKYPNYKYR PRRKAKMLPK NCSLLPADPA
160 170 180 190 200
SVLCSEVQLD NRLYRDDCTK ATHSRMEHQL GHLPPINAAS SPQQRDRYSH

WTKL
Length:204
Mass (Da):23,884
Last modified:October 23, 2007 - v1
Checksum:i84323C30A9C2173E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ811904 Genomic DNA Translation: AFG33929.1
JQ811905 Genomic DNA Translation: AFG33930.1
JQ811906 Genomic DNA Translation: AFG33931.1
JQ811907 Genomic DNA Translation: AFG33932.1
JQ811908 Genomic DNA Translation: AFG33933.1
JQ811909 Genomic DNA Translation: AFG33934.1
JQ811910 Genomic DNA Translation: AFG33935.1
JQ811911 Genomic DNA Translation: AFG33936.1
JQ811913 Genomic DNA Translation: AFG33937.1
JQ811915 Genomic DNA Translation: AFG33938.1
JQ811916 Genomic DNA Translation: AFG33939.1
JQ811917 Genomic DNA Translation: AFG33940.1
JQ811919 Genomic DNA Translation: AFG33942.1
JQ811922 Genomic DNA Translation: AFG33944.1
JQ811923 Genomic DNA Translation: AFG33945.1
JQ811924 Genomic DNA Translation: AFG33946.1
JQ811925 Genomic DNA Translation: AFG33947.1
JQ811926 Genomic DNA Translation: AFG33948.1
JQ811927 Genomic DNA Translation: AFG33949.1
JQ811928 Genomic DNA Translation: AFG33950.1
JQ811929 Genomic DNA Translation: AFG33951.1
JQ811930 Genomic DNA Translation: AFG33952.1
JQ811933 Genomic DNA Translation: AFG33954.1
JQ811934 Genomic DNA Translation: AFG33955.1
KF413436 Genomic DNA Translation: AGZ62969.1
KF413440 Genomic DNA Translation: AGZ62973.1
AM884747 Genomic DNA Translation: CAP05198.1
AM884750 Genomic DNA Translation: CAP05201.1
FN568067 Genomic DNA Translation: CBH40188.1
FN568068 Genomic DNA Translation: CBH40189.1
FN568069 Genomic DNA Translation: CBH40190.1
FN568070 Genomic DNA Translation: CBH40191.1
FN568071 Genomic DNA Translation: CBH40192.1
FN568073 Genomic DNA Translation: CBH40194.1
FN568074 Genomic DNA Translation: CBH40195.1
FN568075 Genomic DNA Translation: CBH40196.1
FN568076 Genomic DNA Translation: CBH40197.1
FN568077 Genomic DNA Translation: CBH40198.1
FN568078 Genomic DNA Translation: CBH40199.1
FN568079 Genomic DNA Translation: CBH40200.1
FN568080 Genomic DNA Translation: CBH40201.1
FN568081 Genomic DNA Translation: CBH40202.1
FN568082 Genomic DNA Translation: CBH40203.1
FN568083 Genomic DNA Translation: CBH40204.1
FN568084 Genomic DNA Translation: CBH40205.1
FN568085 Genomic DNA Translation: CBH40206.1
FN568086 Genomic DNA Translation: CBH40207.1
FN568087 Genomic DNA Translation: CBH40208.1
FN568088 Genomic DNA Translation: CBH40209.1
CH471115 Genomic DNA Translation: EAX02769.1
RefSeqiNP_003131.1, NM_003140.2
UniGeneiHs.1992

Genome annotation databases

GeneIDi6736
KEGGihsa:6736

Similar proteinsi

Entry informationi

Entry nameiA7WPU8_HUMAN
AccessioniPrimary (citable) accession number: A7WPU8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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