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Protein

Calcium-activated potassium channel subunit beta-3

Gene

Kcnmb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. May partially inactivate the current of KCNBMA. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-1296052. Ca2+ activated K+ channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-3
Alternative name(s):
Calcium-activated potassium channel subfamily M subunit beta-3
Maxi K channel subunit beta-3
Gene namesi
Name:Kcnmb3Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1311852. Kcnmb3.

Subcellular locationi

  • Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151CytoplasmicSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Topological domaini73 – 197125ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST
Topological domaini219 – 23921CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Calcium-activated potassium channel subunit beta-3PRO_0000312595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity
The extracellular domain contains disulfide bond essential for the gating mechanism.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA7VL23.
PRIDEiA7VL23.

Interactioni

Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055650.

Family & Domainsi

Domaini

The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF7H. Eukaryota.
ENOG410YQCT. LUCA.
GeneTreeiENSGT00390000015997.
HOGENOMiHOG000290180.
HOVERGENiHBG108059.
InParanoidiA7VL23.
KOiK04939.
OMAiKPFMLST.
OrthoDBiEOG77WWDC.
PhylomeDBiA7VL23.
TreeFamiTF328589.

Family and domain databases

InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7VL23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPFSIPVQI TLQGGRRRQG RTALPASGIS NGDPLKVHPK LPSSAGEDRA
60 70 80 90 100
TLLGIAMMAS SVLMFFLLGT TVLKPFMLSS PREESNCTTV HTHIADDWLD
110 120 130 140 150
FAFTCEGSCQ GQGTYPCLQV FVNLSHSGQK VLLHYDEEAI RTNPKCFYTP
160 170 180 190 200
KCHGDRDHLL NSALDIKEFF DHNNGTFPCF YSPDGPLGVV LRKSGHKVVF
210 220 230
HCLFWPLLTL LGGALIVGLV RLTQHLSFQC EKYRAVVRA
Length:239
Mass (Da):26,447
Last modified:October 23, 2007 - v1
Checksum:i090A87142030B2FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB297662 mRNA. Translation: BAF79924.1.
RefSeqiNP_001098030.1. NM_001104560.2.
UniGeneiRn.218452.

Genome annotation databases

EnsembliENSRNOT00000058860; ENSRNOP00000055650; ENSRNOG00000027836.
GeneIDi310303.
KEGGirno:310303.
UCSCiRGD:1311852. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB297662 mRNA. Translation: BAF79924.1.
RefSeqiNP_001098030.1. NM_001104560.2.
UniGeneiRn.218452.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055650.

Proteomic databases

PaxDbiA7VL23.
PRIDEiA7VL23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000058860; ENSRNOP00000055650; ENSRNOG00000027836.
GeneIDi310303.
KEGGirno:310303.
UCSCiRGD:1311852. rat.

Organism-specific databases

CTDi27094.
RGDi1311852. Kcnmb3.

Phylogenomic databases

eggNOGiENOG410IF7H. Eukaryota.
ENOG410YQCT. LUCA.
GeneTreeiENSGT00390000015997.
HOGENOMiHOG000290180.
HOVERGENiHBG108059.
InParanoidiA7VL23.
KOiK04939.
OMAiKPFMLST.
OrthoDBiEOG77WWDC.
PhylomeDBiA7VL23.
TreeFamiTF328589.

Enzyme and pathway databases

ReactomeiR-RNO-1296052. Ca2+ activated K+ channels.

Miscellaneous databases

PROiA7VL23.

Family and domain databases

InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Potassium large conductance calcium-activated channel, subfamily M, beta member 3 (Kcnmb3)."
    Ishii H., Usui S., Sakuma Y.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Testis.

Entry informationi

Entry nameiKCMB3_RAT
AccessioniPrimary (citable) accession number: A7VL23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 23, 2007
Last modified: June 8, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.