A7UWH7 (AMPP2_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase NCU11288
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

NCU11288

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › Neurospora crassa

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Probable Xaa-Pro aminopeptidase NCU11288		PRO_0000411841
Sites
	Metal binding	264	1	Manganese 2 By similarity
	Metal binding	275	1	Manganese 1 By similarity
	Metal binding	275	1	Manganese 2 By similarity
	Metal binding	398	1	Manganese 1 By similarity
	Metal binding	438	1	Manganese 1 By similarity
	Metal binding	438	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7UWH7 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: B56995F7E2CEF5B2	FASTA	468	52,536
	10 20 30 40 50 60 MTTTAARMDF ETTLKGKYPA KRHAQRVADY IRNKMPGASG VLYLEGRATK LLEDNDEAEP 70 80 90 100 110 120 FRQRRYFYYL TGCPLADCHY MYDLDADKST LFIPPIDPDS VIWSGLPVSV DEAKQRWDVD 130 140 150 160 170 180 DVKYTSDVNA TLAHVGSSKP KGSSVFALAN QVSDKVTFLE FDNKNFSILK EAIEVTRVVK 190 200 210 220 230 240 DEYELAIMAK ANEISSDGHK MVMQKVKHVQ NERELEAVFL GHCIAKGARN QAYHSIVASG 250 260 270 280 290 300 RAAATLHYVP NNADMAGKLN LLLDAGGEWD CYASDITRTF PINGKFTKES REIYDIVLKM 310 320 330 340 350 360 QNECIAALKE GVLWDDVHLL AHKIAIDGLL QIGILQGDKD EILESRTSVA FFPHGLGHYL 370 380 390 400 410 420 GMDTHDTGGN PNYADKDTMF RYLRVRGRLP AGSVITVEPG IYFCNFIIEP FLKDPKHSKY 430 440 450 460 INADVLEKYW DVGGVRIEDN LVITKDGTYN LTTAPKDPEE MEKIIQQS

References

[1]

"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABX02000017 Genomic DNA. Translation: EDO65188.1.
RefSeq	XP_001728279.1. XM_001728227.1.
UniGene	Ncr.16446.
3D structure databases
ProteinModelPortal	A7UWH7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000004637; EFNCRP00000004637; EFNCRG00000004631.
GeneID	5847519.
KEGG	ncr:NCU11288.
Phylogenomic databases
eggNOG	COG0006.
HOGENOM	HOG000008763.
KO	K14213.
OMA	MFRYLRV.
OrthoDB	EOG4J40RD.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_NEUCR

Accession

Primary (citable) accession number: A7UWH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	October 23, 2007
Last modified:	April 3, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program